日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis

发现一种ITK和TRK激酶抑制剂,可用于治疗特应性皮炎。

Duffen, Jennifer L; Crouse, Kimberly K; Ji, Lin; Brault, Amy L; Ford, Kristen; Brooks, Jonathan; Jelinsky, Scott A; Li, Yizheng; Shin, Julia H; Zhao, Yajuan; Andreyeva, Tatyana; Hammerman, Katherine; Arnold, Christina; Sheldon, Richard T; Garren, Jeonifer; LaBarge, Wes; Resek, Anthony; Volmer, Jon; Bagley, Scott W; Casimiro-Garcia, Agustin; Chinigo, Gary M; Davoren, Jennifer E; Denny, Rajiah Aldrin; Drozda, Susan; Foley, Timothy L; Hicklin, Robert W; Liu, Shenping; Lovering, Frank E; Nedoma, Nicole L; Parikh, Mihir D; Strohbach, Joseph W; Trujillo, John I; Steyn, Stefanus J; Nocka, Karl; Hegen, Martin; Vincent, Fabien; Lee, Katherine L; Gerstenberger, Brian S; Primiano, Michael J

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca(2+) dependent allosteric binding site.

通过靶向 Ca(2+) 依赖性变构结合位点来抑制肽基精氨酸脱亚胺酶 (PAD1-4)

Dakin Leslie A, Xing Li, Hall Justin, Ding Weidong, Vajdos Felix F, Pelker Jeffrey W, Ramsey Simeon, Balbo Paul, Sahasrabudhe Parag V, Banker Mary Ellen, Choi Won Young, Wright Stephen W, Chang Jeanne S, Curto John M, Davoren Jennifer E, Drozda Susan E, Fennell Kimberly F, Futatsugi Kentaro, Kortum Steve, Lee Katherine L, Liu Shenping, Lovering Frank, Nicki Jennifer A, Trujillo John I, Vincent Fabien, Schnute Mark E

Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule

通过置换被捕获的水分子来优化肽基精氨酸脱亚胺酶(PAD)抑制剂

Schnute, Mark E; Chinigo, Gary M; Futatsugi, Kentaro; Yamaguchi, Masaya; Bagley, Scott W; Banker, Mary Ellen; Chang, Jeanne S; Chen, Ming Z; Choi, Won Young; Corbett, Matthew S; Drozda, Susan E; Ebner, David C; Garcia-Irizarry, Carmen; Hicklin, Robert; Hoy, Susan; Jiao, Wenhua; Kortum, Steven; Lee, Katherine L; Limburg, David C; Lovering, Frank; Moreno, Antonio; Mousseau, James J; Pan, Senliang; Parikh, Mihir D; Pelker, Jeffrey W; Ramsey, Simeon; Reilly, Usa; Rescourio, Gwenaella; Schmitt, Daniel C; Simpson, Brittany; Skrzypek, Grzegorz J; Smaltz, Daniel J; Taylor, Alexandria P; Torella, Rubben; Trujillo, John I; Vajdos, Felix F; Wepy, James A; Wright, Stephen W; Blakemore, David C; Vincent, Fabien; Clerin, Valerie M

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists

大环维甲酸受体相关孤儿受体C2反向激动剂

Schnute, Mark E; Trujillo, John I; Lee, Katherine L; Unwalla, Ray; Vajdos, Felix F; Kauppi, Björn; Nuhant, Philippe; Flick, Andrew C; Crouse, Kimberly K; Zhao, Yajuan; Samuel, Amanda; Lombardo, Vincent; Taylor, Alexandria P; Brault, Amy L; Knafels, John D; Vazquez, Michael L; Berstein, Gabriel

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

氨基吡唑羧酰胺类布鲁顿酪氨酸激酶抑制剂。不可逆到可逆共价反应基团调控

Schnute, Mark E; Benoit, Stephen E; Buchler, Ingrid P; Caspers, Nicole; Grapperhaus, Margaret L; Han, Seungil; Hotchandani, Rajeev; Huang, Nelson; Hughes, Robert O; Juba, Brian M; Kim, Kyung-Hee; Liu, Erica; McCarthy, Erin; Messing, Dean; Miyashiro, Joy S; Mohan, Shashi; O'Connell, Thomas N; Ohren, Jeffrey F; Parikh, Mihir D; Schmidt, Michelle; Selness, Shaun R; Springer, John R; Thanabal, Venkataraman; Trujillo, John I; Walker, Daniel P; Wan, Zhao-Kui; Withka, Jane M; Wittwer, Arthur J; Wood, Nancy L; Xing, Li; Zapf, Christoph W; Douhan, John 3rd

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

发现一种口服高效选择性造血前列腺素D合成酶(HPGDS)抑制剂

Carron, Chris P; Trujillo, John I; Olson, Kirk L; Huang, Wei; Hamper, Bruce C; Dice, Tom; Neal, Bradley E; Pelc, Matthew J; Day, Jacqueline E; Rohrer, Douglas C; Kiefer, James R; Moon, Joseph B; Schweitzer, Barbara A; Blake, Tanisha D; Turner, Steve R; Woerndle, Rhonda; Case, Brenda L; Bono, Christine P; Dilworth, Vickie M; Funckes-Shippy, Christie L; Hood, Becky L; Jerome, Gina M; Kornmeier, Christine M; Radabaugh, Melissa R; Williams, Melanie L; Davies, Michael S; Wegner, Craig D; Welsch, Dean J; Abraham, William M; Warren, Chad J; Dowty, Martin E; Hua, Fengmei; Zutshi, Anup; Yang, Jerry Z; Thorarensen, Atli