Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
发现一种小分子抑制剂,该抑制剂能将Polθ捕获在DNA上,并与PARP抑制剂产生协同作用。
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-46593-1
William Fried # ,Mrityunjay Tyagi # ,Leonid Minakhin ,Gurushankar Chandramouly ,Taylor Tredinnick ,Mercy Ramanjulu ,William Auerbacher ,Marissa Calbert ,Timur Rusanov ,Trung Hoang ,Nikita Borisonnik ,Robert Betsch ,John J Krais ,Yifan Wang ,Umeshkumar M Vekariya ,John Gordon ,George Morton ,Tatiana Kent ,Tomasz Skorski ,Neil Johnson ,Wayne Childers ,Xiaojiang S Chen ,Richard T Pomerantz