日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors

基于结构的新型螺哌啶类ASH1L抑制剂的开发

Guang Huang ,Rhiannon Stevens ,Devon G Hucek ,Trupta Purohit ,Shuangjiang Li ,Hongzhi Miao ,Elise Trost ,Geoff Hewett ,Bradley Clegg ,Se Ra Park ,Krishani Rajanayake ,Bo Wen ,Duxin Sun ,Tomasz Cierpicki ,Jolanta Grembecka

CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts

CCN2在人类真皮成纤维细胞中发挥细胞周期调控调节因子的作用

Quan, Taihao; Shao, Yuan; Purohit, Trupta; Jiang, Yiou; Qin, Zhaoping; Fisher, Gary J; Lents, Nathan H; Baldassare, Joseph J

Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations

menin 和激酶抑制剂联合治疗 NUP98 易位白血病是一种有效疗法

Miao, Hongzhi; Chen, Dong; Ropa, James; Purohit, Trupta; Kim, EunGi; Sulis, Maria-Luisa; Ferrando, Adolfo; Cierpicki, Tomasz; Grembecka, Jolanta

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

发现具有抗白血病活性的 ASH1L 组蛋白甲基转移酶的首创抑制剂

David S Rogawski # ,Jing Deng # ,Hao Li # ,Hongzhi Miao ,Dmitry Borkin ,Trupta Purohit ,Jiho Song ,Jennifer Chase ,Shuangjiang Li ,Juliano Ndoj ,Szymon Klossowski ,EunGi Kim ,Fengbiao Mao ,Bo Zhou ,James Ropa ,Marta Z Krotoska ,Zhuang Jin ,Patricia Ernst ,Xiaomin Feng ,Gang Huang ,Kenichi Nishioka ,Samantha Kelly ,Miao He ,Bo Wen ,Duxin Sun ,Andrew Muntean ,Yali Dou ,Ivan Maillard ,Tomasz Cierpicki ,Jolanta Grembecka

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

靶向多梳抑制复合物1 RING结构域的小分子抑制剂

Shirish Shukla # ,Weijiang Ying # ,Felicia Gray # ,Yiwu Yao # ,Miranda L Simes # ,Qingjie Zhao ,Hongzhi Miao ,Hyo Je Cho ,Paula González-Alonso ,Alyssa Winkler ,George Lund ,Trupta Purohit ,EunGi Kim ,Xiaotian Zhang ,Joshua M Ray ,Shihan He ,Caroline Nikolaidis ,Juliano Ndoj ,Jingya Wang ,Łukasz Jaremko ,Mariusz Jaremko ,Russell J H Ryan ,Monica L Guzman ,Jolanta Grembecka ,Tomasz Cierpicki

EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma

EWS-FLI1 和 Menin 融合调节尤文氏肉瘤中的 ATF4 活性

Jennifer A Jiménez, April A Apfelbaum, Allegra G Hawkins, Laurie K Svoboda, Abhijay Kumar, Ramon Ocadiz Ruiz, Alessandra X Garcia, Elena Haarer, Zeribe C Nwosu, Joshua Bradin, Trupta Purohit, Dong Chen, Tomasz Cierpicki, Jolanta Grembecka, Costas A Lyssiotis, Elizabeth R Lawlor

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Menin抑制剂MI-3454可诱导MLL1重排和NPM1突变型白血病模型缓解

Szymon Klossowski ,Hongzhi Miao ,Katarzyna Kempinska ,Tao Wu ,Trupta Purohit ,EunGi Kim ,Brian M Linhares ,Dong Chen ,Gloria Jih ,Eric Perkey ,Huang Huang ,Miao He ,Bo Wen ,Yi Wang ,Ke Yu ,Stanley Chun-Wei Lee ,Gwenn Danet-Desnoyers ,Winifred Trotman ,Malathi Kandarpa ,Anitria Cotton ,Omar Abdel-Wahab ,Hongwei Lei ,Yali Dou ,Monica Guzman ,Luke Peterson ,Tanja Gruber ,Sarah Choi ,Duxin Sun ,Pingda Ren ,Lian-Sheng Li ,Yi Liu ,Francis Burrows ,Ivan Maillard ,Tomasz Cierpicki ,Jolanta Grembecka

Covalent inhibition of NSD1 histone methyltransferase

NSD1组蛋白甲基转移酶的共价抑制

Huang Huang #, Christina A Howard #, Sergei Zari #, Hyo Je Cho #, Shirish Shukla #, Hao Li, Juliano Ndoj, Paula González-Alonso, Caroline Nikolaidis, Joshua Abbott, David S Rogawski, Mykhaylo A Potopnyk, Katarzyna Kempinska, Hongzhi Miao, Trupta Purohit, Andrew Henderson, Anna Mapp, Maria Luisa Suli

Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction

阻断二价蛋白-蛋白相互作用的复杂性:Menin-混合谱系白血病相互作用高效抑制剂的开发

Borkin, Dmitry; Klossowski, Szymon; Pollock, Jonathan; Miao, Hongzhi; Linhares, Brian M; Kempinska, Katarzyna; Jin, Zhuang; Purohit, Trupta; Wen, Bo; He, Miao; Sun, Duxin; Cierpicki, Tomasz; Grembecka, Jolanta

Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts

Smad3 依赖的 CCN2 介导人类皮肤真皮成纤维细胞中的纤连蛋白表达

Trupta Purohit, Zhaoping Qin, Chunji Quan, Zhenhua Lin, Taihao Quan