日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Federated single-cell QTL meta-analysis reveals novel disease mechanisms

联合单细胞QTL荟萃分析揭示了新的疾病机制

Kaptijn, Daniel; Michielsen, Lieke; Neavin, Drew; Ripoll-Cladellas, Aida; Alquicira-Hernández, José; Korshevniuk, Maryna; Lee, Jimmy Tsz Hang; Oelen, Roy; Vochteloo, Martijn; Warmerdam, Robert; Ando, Yoshinari; Ban, Maria; Bayaraa, Odmaa; Berg, Marijn; van Blokland, Irene; Considine, Daniel; Dieng, Mame M; Edahiro, Ryuya; Gordon, M Grace; Groot, Hilde E; van der Harst, Pim; Heinig, Matthias; Hon, Chung-Chau; Idaghdour, Youssef; Kathail, Pooja; de Klein, Niek; Li, Wenchao; Li, Yang; Losert, Corinna; Manikanda, Vinu; Moody, Jonathan; Naeem, Haroon; Mokrab, Younes; Nawijn, Martijn C; Netea, Mihai; Niewold, Jelmer; Okada, Yukinori; Sawcer, Stephen; Soulama, Issiaka; Stegle, Oliver; Tsepilov, Yakov; Park, Woong-Yang; Rajagopalan, Deepa; Shahin, Tala; Shin, Jay W; Trynka, Gosia; Võsa, Urmo; Westra, Harm-Jan; Yazar, Seyhan; Ye, Jimmie; Zhang, Zhenhua; Hemberg, Martin; Mahfouz, Ahmed; Melé, Marta; Powell, Joseph E; Bonder, Marc Jan; Franke, Lude; van der Wijst, Monique G P

Article Watch: December, 2025

文章预告:2025年12月

Laman Trip, Diederik S; van Oostrum, Marc; Memon, Danish; Frommelt, Fabian; Baptista, Delora; Panneerselvam, Kalpana; Bradley, Glyn; Licata, Luana; Hermjakob, Henning; Orchard, Sandra; Trynka, Gosia; McDonagh, Ellen M; Fossati, Andrea; Aebersold, Ruedi; Gstaiger, Matthias; Wollscheid, Bernd; Beltrao, Pedro; Slaughter, Clive

ONE-STEP tagging: a versatile method for rapid site-specific integration by simultaneous reagent delivery

一步标记:一种通过同时递送试剂实现快速位点特异性整合的多功能方法

Valentina Migliori,Michaela B Bruntraeger,Ivan S Gyulev,Florence Lichou,Thomas Burgold,Daniel P Gitterman,Sho Iwama,Andrew L Trinh,Sam J Washer,Carla P Jones,Gosia Trynka,Andrew R Bassett

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

跨eQTL定位将USP18确定为狼疮风险位点上干扰素反应的负调控因子

Freimann, Krista; Brümmer, Anneke; Warmerdam, Robert; Rupall, Tarran S; Hernández-Ledesma, Ana Laura; Chiou, Joshua; Holzinger, Emily R; Maranville, Joseph C; Nakic, Nikolina; Ongen, Halit; Stefanucci, Luca; Turchin, Michael C; Franke, Lude; Võsa, Urmo; Jones, Carla P; Medina-Rivera, Alejandra; Trynka, Gosia; Kisand, Kai; Bergmann, Sven; Alasoo, Kaur

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

免疫疾病风险变异在 CD4+ T 细胞活化过程中调节基因表达动态

Blagoje Soskic #, Eddie Cano-Gamez #, Deborah J Smyth, Kirsty Ambridge, Ziying Ke, Julie C Matte, Lara Bossini-Castillo, Joanna Kaplanis, Lucia Ramirez-Navarro, Anna Lorenc, Nikolina Nakic, Jorge Esparza-Gordillo, Wendy Rowan, David Wille, David F Tough, Paola G Bronson, Gosia Trynka

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

与精神疾病相关的遗传变异在淋巴细胞的表观遗传活跃位点富集。

Lynall, Mary-Ellen; Soskic, Blagoje; Hayhurst, James; Schwartzentruber, Jeremy; Levey, Daniel F; Pathak, Gita A; Polimanti, Renato; Gelernter, Joel; Stein, Murray B; Trynka, Gosia; Clatworthy, Menna R; Bullmore, Ed

Robust temporal map of human in vitro myelopoiesis using single-cell genomics

使用单细胞基因组学绘制人类体外髓系生成的稳健时间图

Clara Alsinet, Maria Nascimento Primo, Valentina Lorenzi, Erica Bello, Iva Kelava, Carla P Jones, Roser Vilarrasa-Blasi, Carmen Sancho-Serra, Andrew J Knights, Jong-Eun Park, Beata S Wyspianska, Gosia Trynka, David F Tough, Andrew Bassett, Daniel J Gaffney, Damiana Alvarez-Errico, Roser Vento-Tormo

Immune disease variants modulate gene expression in regulatory CD4+ T cells

免疫疾病变异体调节调节性CD4+ T细胞中的基因表达

Lara Bossini-Castillo ,Dafni A Glinos ,Natalia Kunowska ,Gosia Golda ,Abigail A Lamikanra ,Michaela Spitzer ,Blagoje Soskic ,Eddie Cano-Gamez ,Deborah J Smyth ,Claire Cattermole ,Kaur Alasoo ,Alice Mann ,Kousik Kundu ,Anna Lorenc ,Nicole Soranzo ,Ian Dunham ,David J Roberts ,Gosia Trynka

Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia

单细胞转录组学定义了一种改进的、经过验证的单培养方案,用于将人类 iPSC 分化为小胶质细胞

Sam J Washer, Marta Perez-Alcantara, Yixi Chen, Juliette Steer, William S James, Gosia Trynka, Andrew R Bassett, Sally A Cowley

A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells

位于风险位点 11q13.5 的远端增强子促进 Treg 细胞对结肠炎的抑制作用。

Rabab Nasrallah # ,Charlotte J Imianowski # ,Lara Bossini-Castillo ,Francis M Grant ,Mikail Dogan ,Lindsey Placek ,Lina Kozhaya ,Paula Kuo ,Firas Sadiyah ,Sarah K Whiteside ,Maxwell R Mumbach ,Dafni Glinos ,Panagiota Vardaka ,Carly E Whyte ,Teresa Lozano ,Toshitsugu Fujita ,Hodaka Fujii ,Adrian Liston ,Simon Andrews ,Adeline Cozzani ,Jie Yang ,Suman Mitra ,Enrico Lugli ,Howard Y Chang ,Derya Unutmaz ,Gosia Trynka ,Rahul Roychoudhuri