日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

BACE1 通过酶促和非酶促作用调节睡眠-觉醒周期。

Heininger Hannah, Feng Xiao, Altunkaya Alp, Zheng Fang, Stockinger Florian, Wefers Benedikt, Müller Stephan A, Giesbertz Pieter, Tschirner Sarah K, Shqau Dorina, Adelsberger Helmuth, Ponomarenko Alexey, Fenzl Thomas, Alzheimer Christian, Lichtenthaler Stefan F, Huth Tobias

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates

在非人灵长类动物中进行亚慢性给药时,Elenbecestat 和化合物 89 能有效抑制 BACE1,但对 BACE2 没有抑制作用。

Tschirner, Sarah K; Schmidt, Andree; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Müller, Stephan A; Horiguchi, Naotaka; Lichtenthaler, Stefan F

Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration

患者来源的神经元表现出α-突触核蛋白病理和先前未被识别的线粒体膜蛋白相关神经退行性疾病中的主要组织相容性复合体I类分子升高

Heger, Leonie M; Kertess, Leonie; Kaufhold, Clara; Gubinelli, Francesco; Cardona-Alberich, Aida; Özata, Gamze; Müller, Stephan A; Tschirner, Sarah K; Stehling, Oliver; Schifferer, Martina; Peron, Camille; Tiranti, Valeria; Lill, Roland; Iuso, Arcangela; Zecca, Luigi; Strupp, Michael; Oertel, Wolfgang; Lichtenthaler, Stefan F; Burbulla, Lena F

Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.

可溶性 VCAM-1 可作为药效学脑脊液标志物,用于监测非人灵长类动物的 BACE2 活性

Tschirner Sarah K, Zuchero Y Joy Yu, Getz Jennifer A, Müller Stephan A, Nalbach Karsten, Kennedy Matthew E, Lewcock Joseph W, Lichtenthaler Stefan F