日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia

基于CRISPR/Cas9的多重基因组编辑在人类造血干细胞中模拟克隆性造血和髓系肿瘤

Tothova, Zuzana; Krill-Burger, John M; Popova, Katerina D; Landers, Catherine C; Sievers, Quinlan L; Yudovich, David; Belizaire, Roger; Aster, Jon C; Morgan, Elizabeth A; Tsherniak, Aviad; Ebert, Benjamin L

Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

当 CRISPR-Cas9 基因敲除导致全致死时,部分基因抑制可以更好地识别癌症的脆弱性。

Krill-Burger, J Michael; Dempster, Joshua M; Borah, Ashir A; Paolella, Brenton R; Root, David E; Golub, Todd R; Boehm, Jesse S; Hahn, William C; McFarland, James M; Vazquez, Francisca; Tsherniak, Aviad

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

作者更正:在部分癌细胞中鉴定出ADAR1腺苷脱氨酶依赖性

Gannon, Hugh S; Zou, Tao; Kiessling, Michael K; Gao, Galen F; Cai, Diana; Choi, Peter S; Ivan, Alexandru P; Buchumenski, Ilana; Berger, Ashton C; Goldstein, Jonathan T; Cherniack, Andrew D; Vazquez, Francisca; Tsherniak, Aviad; Levanon, Erez Y; Hahn, William C; Meyerson, Matthew

Sparse dictionary learning recovers pleiotropy from human cell fitness screens

稀疏字典学习从人类细胞适应性筛查中恢复多效性

Joshua Pan, Jason J Kwon, Jessica A Talamas, Ashir A Borah, Francisca Vazquez, Jesse S Boehm, Aviad Tsherniak, Marinka Zitnik, James M McFarland, William C Hahn

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

胚胎滞育样适应伴随Myc活性抑制,使肿瘤治疗得以持续

Eugen Dhimolea ,Ricardo de Matos Simoes ,Dhvanir Kansara ,Aziz Al'Khafaji ,Juliette Bouyssou ,Xiang Weng ,Shruti Sharma ,Joseline Raja ,Pallavi Awate ,Ryosuke Shirasaki ,Huihui Tang ,Brian J Glassner ,Zhiyi Liu ,Dong Gao ,Jordan Bryan ,Samantha Bender ,Jennifer Roth ,Michal Scheffer ,Rinath Jeselsohn ,Nathanael S Gray ,Irene Georgakoudi ,Francisca Vazquez ,Aviad Tsherniak ,Yu Chen ,Alana Welm ,Cihangir Duy ,Ari Melnick ,Boris Bartholdy ,Myles Brown ,Aedin C Culhane ,Constantine S Mitsiades

A first-generation pediatric cancer dependency map

第一代儿科癌症依赖性图

Dharia, Neekesh V; Kugener, Guillaume; Guenther, Lillian M; Malone, Clare F; Durbin, Adam D; Hong, Andrew L; Howard, Thomas P; Bandopadhayay, Pratiti; Wechsler, Caroline S; Fung, Iris; Warren, Allison C; Dempster, Joshua M; Krill-Burger, John M; Paolella, Brenton R; Moh, Phoebe; Jha, Nishant; Tang, Andrew; Montgomery, Philip; Boehm, Jesse S; Hahn, William C; Roberts, Charles W M; McFarland, James M; Tsherniak, Aviad; Golub, Todd R; Vazquez, Francisca; Stegmaier, Kimberly

Global computational alignment of tumor and cell line transcriptional profiles

肿瘤和细胞系转录谱的全局计算比对

Warren, Allison; Chen, Yejia; Jones, Andrew; Shibue, Tsukasa; Hahn, William C; Boehm, Jesse S; Vazquez, Francisca; Tsherniak, Aviad; McFarland, James M

Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

Chronos:一种用于 CRISPR 实验的细胞群体动力学模型,可提高基因适应性效应的推断准确性。

Dempster, Joshua M; Boyle, Isabella; Vazquez, Francisca; Root, David E; Boehm, Jesse S; Hahn, William C; Tsherniak, Aviad; McFarland, James M

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

泛癌单细胞RNA测序揭示细胞异质性的重复性程序

Kinker, Gabriela S; Greenwald, Alissa C; Tal, Rotem; Orlova, Zhanna; Cuoco, Michael S; McFarland, James M; Warren, Allison; Rodman, Christopher; Roth, Jennifer A; Bender, Samantha A; Kumar, Bhavna; Rocco, James W; Fernandes, Pedro A C M; Mader, Christopher C; Keren-Shaul, Hadas; Plotnikov, Alexander; Barr, Haim; Tsherniak, Aviad; Rozenblatt-Rosen, Orit; Krizhanovsky, Valery; Puram, Sidharth V; Regev, Aviv; Tirosh, Itay

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

多重单细胞转录反应谱分析用于确定癌症脆弱性和治疗作用机制

James M McFarland # ,Brenton R Paolella # ,Allison Warren ,Kathryn Geiger-Schuller ,Tsukasa Shibue ,Michael Rothberg ,Olena Kuksenko ,William N Colgan ,Andrew Jones ,Emily Chambers ,Danielle Dionne ,Samantha Bender ,Brian M Wolpin ,Mahmoud Ghandi ,Itay Tirosh ,Orit Rozenblatt-Rosen ,Jennifer A Roth ,Todd R Golub ,Aviv Regev ,Andrew J Aguirre ,Francisca Vazquez ,Aviad Tsherniak