Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5.
突变亨廷顿蛋白通过解除对非经典聚腺苷酸聚合酶 PAPD5 的抑制来诱导神经元凋亡
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-58618-4
Chen Zhefan Stephen, Peng Shaohong Isaac, Leong Lok I, Gall-Duncan Terence, Wong Nathan Siu Jun, Li Tsz Ho, Lin Xiao, Wei Yuming, Koon Alex Chun, Huang Junzhe, Sun Jacquelyne Ka-Li, Turner Clinton, Tippett Lynette, Curtis Maurice A, Faull Richard L M, Kwan Kin Ming, Chow Hei-Man, Ko Ho, Chan Ting-Fung, Talbot Kevin, Pearson Christopher E, Chan Ho Yin Edwin
