SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance.

SENP1 通过增强胆管癌细胞中的 SUMO 化作用促进 p27kip1 核输出，从而导致细胞增殖增加和化疗耐药性