日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

KRAS4a 和 KRAS4b 对 RAS-RAF 膜动力学表现出不同的脂质依赖性调控作用

Georgouli, Konstantia; Tempkin, Jeremy O B; Stanton, Liam G; Oppelstrup, Tomas; Shrestha, Rebika; Carpenter, Timothy S; Aydin, Fikret; Zhang, Xiaohua; Bhatia, Harsh; Yang, Yue; Van, Que N; Bonilla, Pedro Andrade; Gulten, Gulcin; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moon, Joseph Y; Dharuman, Gautham; Hengartner, Nicolas W; Simanshu, Dhirendra K; Tran, Timothy H; Nguyen, Kien; Stanley, Christopher B; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Glosli, James N; Gnanakaran, Sandrasegaram; Turbyville, Thomas J; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

通过多尺度模拟揭示RAS-RAF复合物的动力学和脂质膜耦合

Carpenter, Timothy S; Aydin, Fikret; Neale, Chris; Van, Que N; Zhang, Xiaohua; Bhatia, Harsh; Sidabras, Jason W; Frank, Peter H; Georgouli, Konstantia; Tempkin, Jeremy O B; Casamayor, Violeta Burns; Gulten, Gulcin; Shrestha, Rebika; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moody, Adam; Moon, Joseph Y; Oppelstrup, Tomas; Glosli, James N; Dharuman, Gautham; Wong, Sergio; Liu, Shusen; Hengartner, Nicolas W; López, Cesar A; Nguyen, Kien; Stanley, Christopher B; Stanton, Liam G; Patel, Lara; Reddy, Tyler; Turbyville, Thomas J; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Gnanakaran, Sandrasegaram; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击,阻断 KRAS4b 的 C 端加工

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

膜脂驱动膜上KRAS4b-RAF1 RBDCRD纳米簇的形成

Shrestha, Rebika; Carpenter, Timothy S; Van, Que N; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N; López, Cesar A; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K; Ingólfsson, Helgi I; Lightstone, Felice C; Stephen, Andrew G; Streitz, Frederick H; Nissley, Dwight V; Turbyville, Thomas J

Machine Learning-Driven Multiscale Modeling: Bridging the Scales with a Next-Generation Simulation Infrastructure

机器学习驱动的多尺度建模:利用下一代仿真基础设施连接不同尺度

Ingólfsson, Helgi I; Bhatia, Harsh; Aydin, Fikret; Oppelstrup, Tomas; López, Cesar A; Stanton, Liam G; Carpenter, Timothy S; Wong, Sergio; Di Natale, Francesco; Zhang, Xiaohua; Moon, Joseph Y; Stanley, Christopher B; Chavez, Joseph R; Nguyen, Kien; Dharuman, Gautham; Burns, Violetta; Shrestha, Rebika; Goswami, Debanjan; Gulten, Gulcin; Van, Que N; Ramanathan, Arvind; Van Essen, Brian; Hengartner, Nicolas W; Stephen, Andrew G; Turbyville, Thomas; Bremer, Peer-Timo; Gnanakaran, S; Glosli, James N; Lightstone, Felice C; Nissley, Dwight V; Streitz, Frederick H

Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

机器学习驱动的多尺度建模揭示了RAS信号蛋白的脂质依赖性动态变化

Ingólfsson, Helgi I; Neale, Chris; Carpenter, Timothy S; Shrestha, Rebika; López, Cesar A; Tran, Timothy H; Oppelstrup, Tomas; Bhatia, Harsh; Stanton, Liam G; Zhang, Xiaohua; Sundram, Shiv; Di Natale, Francesco; Agarwal, Animesh; Dharuman, Gautham; Kokkila Schumacher, Sara I L; Turbyville, Thomas; Gulten, Gulcin; Van, Que N; Goswami, Debanjan; Jean-Francois, Frantz; Agamasu, Constance; Chen, De; Hettige, Jeevapani J; Travers, Timothy; Sarkar, Sumantra; Surh, Michael P; Yang, Yue; Moody, Adam; Liu, Shusen; Van Essen, Brian C; Voter, Arthur F; Ramanathan, Arvind; Hengartner, Nicolas W; Simanshu, Dhirendra K; Stephen, Andrew G; Bremer, Peer-Timo; Gnanakaran, S; Glosli, James N; Lightstone, Felice C; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H

Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells.

卡米霉素 I 是一种凋亡诱导剂,靶向透明细胞肾癌细胞中的高尔基复合体

Woldemichael Girma M, Turbyville Thomas J, Linehan W Marston, McMahon James B

Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.

Schweinfurthin A 以 NF1-GRD 依赖的方式选择性地抑制神经胶质瘤和 1 型神经纤维瘤病肿瘤细胞的增殖和 Rho 信号传导

Turbyville Thomas J, Gürsel Demirkan B, Tuskan Robert G, Walrath Jessica C, Lipschultz Claudia A, Lockett Stephen J, Wiemer David F, Beutler John A, Reilly Karlyne M