日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCs

DNA-PKcs抑制剂AZD7648揭示了sgRNA交叉污染，并增强了造血干细胞中基因组工程脱靶活性的敏感性

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkag318
White, Nathan; Hu, Yi-Ting; Chalk, John Alexander; Kurgan, Gavin; Naseem, Asma; Schmaljohn, Ellen; Sturgeon, Morgan; Cavazza, Alessia; Thrasher, Adrian James; Turchiano, Giandomenico
细胞生物学
发育与干细胞
DNA-PKcs
干细胞
发表日期：2026
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Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR

利用 CLEAR-time dPCR 揭示人类干细胞和 T 细胞中设计核酸酶的切割和修复循环

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-025-65182-4.
Nathan White,John Alexander Chalk,Yi-Ting Hu,Samuel Mark Pins,Chinnu Rose Joseph,Panagiotis Antoniou,Sandra Wimberger,Stina Svensson,Soraia Patricia Caetano-Silva,Anne Charlotte Adriane Mudde,Rajeev Rai,Sridhar Selvaraj,William Nelson Feist,Marianna Romito,Grzegorz Sienski,Roberto Nitsch,Claire Booth,Giorgia Santilli,Alessia Cavazza,Matthew Hebden Porteus,Marcello Maresca,Adrian James Thrasher,Giandomenico Turchiano
Human
细胞生物学
发育与干细胞
干细胞
TIM
发表日期：2025
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Electrocatalytic Upcycling of Plastic Waste to Organonitrogen Chemicals via Intercepting Carbon Intermediates

通过截留碳中间体，利用电催化技术将塑料废弃物升级转化为有机氮化合物

期刊:Nano Letters
影响因子:9.1
doi:10.1021/acs.nanolett.5c02377
Kang, Hongxing; He, Dong; Yan, Xingxu; Weed, Melanie; Chai, Jingtong; Turchiano, Christopher; Pan, Xiaoqing; Xiao, Xiangheng; Gu, Jing
发表日期：2025
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Off-target effects in CRISPR-Cas genome editing for human therapeutics: Progress and challenges

CRISPR-Cas基因组编辑技术在人类治疗中的脱靶效应：进展与挑战

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2025.102636
Kalter, Nechama; Fuster-García, Carla; Silva, Alfredo; Ronco-Díaz, Víctor; Roncelli, Stefano; Turchiano, Giandomenico; Gorodkin, Jan; Cathomen, Toni; Benabdellah, Karim; Lee, Ciaran; Hendel, Ayal
发表日期：2025
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Healthy BRCA1/2 mutation carriers exhibit a pre-CAF signature and altered epithelial marker expression in breast tissue

健康的BRCA1/2突变携带者表现出癌前病变特征和乳腺组织中上皮标志物表达改变。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-18171-y
De Leonardis, Francesco; Di Noia, Maria Antonietta; Turchiano, Antonella; Martino, Stefania; D'Erchia, Anna Maria; Scilimati, Antonio; Cormio, Antonella; Gurrado, Angela; Abate, Carmen; Resta, Nicoletta
BRCA1
肿瘤
肿瘤免疫
发表日期：2025
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Safety and efficacy studies of CRISPR-Cas9 treatment of sickle cell disease highlights disease-specific responses

CRISPR-Cas9治疗镰状细胞病的安全性和有效性研究突显了疾病特异性反应

期刊:Molecular Therapy
影响因子:12.1
doi:10.1016/j.ymthe.2024.07.015
Giacomo Frati ，Megane Brusson ，Gilles Sartre ，Bochra Mlayah ，Tristan Felix ，Anne Chalumeau ，Panagiotis Antoniou ，Giulia Hardouin ，Jean-Paul Concordet ，Oriana Romano ，Giandomenico Turchiano ，Annarita Miccio
细胞生物学
发表日期：2024
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Hematopoietic stem cell gene editing rescues B-cell development in X-linked agammaglobulinemia

造血干细胞基因编辑挽救了X连锁无丙种球蛋白血症患者的B细胞发育

期刊:Journal of Allergy and Clinical Immunology
影响因子:11.4
doi:10.1016/j.jaci.2024.03.003
Sameer Bahal ，Marta Zinicola ，Shefta E Moula ，Thomas E Whittaker ，Andrea Schejtman ，Asma Naseem ，Elena Blanco ，Winston Vetharoy ，Yi-Ting Hu ，Rajeev Rai ，Eduardo Gomez-Castaneda ，Catarina Cunha-Santos ，Siobhan O Burns ，Emma C Morris ，Claire Booth ，Giandomenico Turchiano ，Alessia Cavazza ，Adrian J Thrasher ，Giorgia Santilli
发育与干细胞
免疫/内分泌
细胞生物学
B细胞
干细胞
发表日期：2024
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Investigating adverse genomic and regulatory changes caused by replacement of the full-length CFTR cDNA using Cas9 and AAV

利用Cas9和AAV技术替换全长CFTR cDNA所引起的基因组和调控异常变化及其对基因组和调控的影响。

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1016/j.omtn.2024.102134
Sriram Vaidyanathan ，Jenny L Kerschner ，Alekh Paranjapye ，Vrishti Sinha ，Brian Lin ，Tracy A Bedrosian ，Adrian J Thrasher ，Giandomenico Turchiano ，Ann Harris ，Matthew H Porteus
CFTR
信号转导
发表日期：2024
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CRISPR/Cas9-Based Disease Modeling and Functional Correction of Interleukin 7 Receptor Alpha Severe Combined Immunodeficiency in T-Lymphocytes and Hematopoietic Stem Cells

基于 CRISPR/Cas9 的白细胞介素 7 受体 α 重症联合免疫缺陷疾病建模及功能矫正（T 淋巴细胞和造血干细胞）

期刊:Human Gene Therapy
影响因子:4
doi:10.1089/hum.2023.100
Rai, Rajeev; Steinberg, Zohar; Romito, Marianna; Zinghirino, Federica; Hu, Yi-Ting; White, Nathan; Naseem, Asma; Thrasher, Adrian J; Turchiano, Giandomenico; Cavazza, Alessia
发育与干细胞
信号转导
干细胞
细胞生物学
免疫/内分泌
发表日期：2024
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Genetic Risk Factors in Idiopathic and Non-Idiopathic Interstitial Lung Disease: Similarities and Differences

特发性和非特发性间质性肺病的遗传风险因素：异同点

期刊:Medicina-Lithuania
影响因子:2.4
doi:10.3390/medicina60121967
Cerri, Stefania; Manzini, Elisa; Nori, Ottavia; Pacchetti, Lucia; Rossi, Laura; Turchiano, Maria Giulia; Samarelli, Anna Valeria; Raineri, Giulia; Andrisani, Dario; Gozzi, Filippo; Beghè, Bianca; Clini, Enrico; Tonelli, Roberto
特发性肺纤维化
发表日期：2024
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