日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development and Application of Small Molecule-Peptide Conjugates as Cathepsin K-Specific Covalent Irreversible Inhibitors in Human Osteoclast and Lung Cancer.

小分子肽缀合物作为组织蛋白酶 K 特异性共价不可逆抑制剂在人类破骨细胞和肺癌中的开发与应用

Dey Gourab, Yakobovich Evalyn, Loboda Jure, Sinai-Turyansky Reut, Abramovitch-Dahan Chen, Merquiol Emmanuelle, Sridharan Nikhila, Itzhak Gal, Turk Boris, Wald Ori, Turk Dusan, Yona Simon, Levaot Noam, Blum Galia

Development and Application of Reversible and Irreversible Covalent Probes for Human and Mouse Cathepsin-K Activity Detection, Revealing Nuclear Activity

开发和应用可逆和不可逆共价探针检测人和小鼠组织蛋白酶K活性,揭示核活性

Dey, Gourab; Sinai-Turyansky, Reut; Yakobovich, Evalyn; Merquiol, Emmanuelle; Loboda, Jure; Sridharan, Nikhila; Houri-Haddad, Yael; Polak, David; Yona, Simon; Turk, Dusan; Wald, Ori; Blum, Galia

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

天然酚类化合物与SARS-CoV-2木瓜蛋白酶样蛋白酶变构位点形成复合物的抗病毒活性

Srinivasan, Vasundara; Brognaro, Hévila; Prabhu, Prince R; de Souza, Edmarcia Elisa; Günther, Sebastian; Reinke, Patrick Y A; Lane, Thomas J; Ginn, Helen; Han, Huijong; Ewert, Wiebke; Sprenger, Janina; Koua, Faisal H M; Falke, Sven; Werner, Nadine; Andaleeb, Hina; Ullah, Najeeb; Franca, Bruno Alves; Wang, Mengying; Barra, Angélica Luana C; Perbandt, Markus; Schwinzer, Martin; Schmidt, Christina; Brings, Lea; Lorenzen, Kristina; Schubert, Robin; Machado, Rafael Rahal Guaragna; Candido, Erika Donizette; Oliveira, Danielle Bruna Leal; Durigon, Edison Luiz; Niebling, Stephan; Garcia, Angelica Struve; Yefanov, Oleksandr; Lieske, Julia; Gelisio, Luca; Domaracky, Martin; Middendorf, Philipp; Groessler, Michael; Trost, Fabian; Galchenkova, Marina; Mashhour, Aida Rahmani; Saouane, Sofiane; Hakanpää, Johanna; Wolf, Markus; Alai, Maria Garcia; Turk, Dusan; Pearson, Arwen R; Chapman, Henry N; Hinrichs, Winfried; Wrenger, Carsten; Meents, Alke; Betzel, Christian

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

X射线筛选鉴定SARS-CoV-2主蛋白酶的活性位点和变构抑制剂

Günther, Sebastian; Reinke, Patrick Y A; Fernández-García, Yaiza; Lieske, Julia; Lane, Thomas J; Ginn, Helen M; Koua, Faisal H M; Ehrt, Christiane; Ewert, Wiebke; Oberthuer, Dominik; Yefanov, Oleksandr; Meier, Susanne; Lorenzen, Kristina; Krichel, Boris; Kopicki, Janine-Denise; Gelisio, Luca; Brehm, Wolfgang; Dunkel, Ilona; Seychell, Brandon; Gieseler, Henry; Norton-Baker, Brenna; Escudero-Pérez, Beatriz; Domaracky, Martin; Saouane, Sofiane; Tolstikova, Alexandra; White, Thomas A; Hänle, Anna; Groessler, Michael; Fleckenstein, Holger; Trost, Fabian; Galchenkova, Marina; Gevorkov, Yaroslav; Li, Chufeng; Awel, Salah; Peck, Ariana; Barthelmess, Miriam; Schlünzen, Frank; Lourdu Xavier, P; Werner, Nadine; Andaleeb, Hina; Ullah, Najeeb; Falke, Sven; Srinivasan, Vasundara; França, Bruno Alves; Schwinzer, Martin; Brognaro, Hévila; Rogers, Cromarte; Melo, Diogo; Zaitseva-Kinneberg, Joanna Irina; Knoska, Juraj; Peña-Murillo, Gisel E; Mashhour, Aida Rahmani; Hennicke, Vincent; Fischer, Pontus; Hakanpää, Johanna; Meyer, Jan; Gribbon, Philip; Ellinger, Bernhard; Kuzikov, Maria; Wolf, Markus; Beccari, Andrea R; Bourenkov, Gleb; von Stetten, David; Pompidor, Guillaume; Bento, Isabel; Panneerselvam, Saravanan; Karpics, Ivars; Schneider, Thomas R; Garcia-Alai, Maria Marta; Niebling, Stephan; Günther, Christian; Schmidt, Christina; Schubert, Robin; Han, Huijong; Boger, Juliane; Monteiro, Diana C F; Zhang, Linlin; Sun, Xinyuanyuan; Pletzer-Zelgert, Jonathan; Wollenhaupt, Jan; Feiler, Christian G; Weiss, Manfred S; Schulz, Eike-Christian; Mehrabi, Pedram; Karničar, Katarina; Usenik, Aleksandra; Loboda, Jure; Tidow, Henning; Chari, Ashwin; Hilgenfeld, Rolf; Uetrecht, Charlotte; Cox, Russell; Zaliani, Andrea; Beck, Tobias; Rarey, Matthias; Günther, Stephan; Turk, Dusan; Hinrichs, Winfried; Chapman, Henry N; Pearson, Arwen R; Betzel, Christian; Meents, Alke

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

炔烃部分作为不可逆共价小分子组织蛋白酶K抑制剂中的潜在亲电试剂

Mons, Elma; Jansen, Ineke D C; Loboda, Jure; van Doodewaerd, Bjorn R; Hermans, Jill; Verdoes, Martijn; van Boeckel, Constant A A; van Veelen, Peter A; Turk, Boris; Turk, Dusan; Ovaa, Huib

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

反向选择底物库策略用于开发特异性蛋白酶底物和探针

Poreba Marcin, Solberg Rigmor, Rut Wioletta, Lunde Ngoc Nguyen, Kasperkiewicz Paulina, Snipas Scott J, Mihelic Marko, Turk Dusan, Turk Boris, Salvesen Guy S, Drag Marcin

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

在生理 pH 值和氧化还原条件下监测组织蛋白酶 B、K、L 和 S 对特定细胞区室底物的裂解

Jordans, Silvia; Jenko-Kokalj, Sasa; Kühl, Nicole M; Tedelind, Sofia; Sendt, Wolfgang; Brömme, Dieter; Turk, Dusan; Brix, Klaudia

PURY: a database of geometric restraints of hetero compounds for refinement in complexes with macromolecular structures

PURY:用于优化具有大分子结构的复合物的杂环化合物几何约束数据库

Andrejasic, Miha; Praaenikar, Jure; Turk, Dusan

Interpretation of ensembles created by multiple iterative rebuilding of macromolecular models

对通过多次迭代重建大分子模型而创建的集合进行解释

Terwilliger, Thomas C; Grosse-Kunstleve, Ralf W; Afonine, Pavel V; Adams, Paul D; Moriarty, Nigel W; Zwart, Peter; Read, Randy J; Turk, Dusan; Hung, Li Wei

Crystallization and preliminary X-ray crystallographic analysis of the cysteine protease inhibitor clitocypin

半胱氨酸蛋白酶抑制剂clitocypin的结晶及初步X射线晶体学分析

Galesa, Katja; Brzin, Joze; Sabotic, Jerica; Turk, Dusan