日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I Trial of TTI-101, a First-in-Class Oral Inhibitor of STAT3, in Patients with Advanced Solid Tumors

TTI-101(一种首创的口服STAT3抑制剂)治疗晚期实体瘤患者的I期临床试验

Tsimberidou, Apostolia M; Vining, David J; Arora, Sukeshi P; de Achaval, Sofia; Larson, Jeffrey; Kauh, John; Cartwright, Carrie; Avritscher, Rony; Alibhai, Imran; Tweardy, David J; Kaseb, Ahmed O

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer.

IL-6 预测 CDK4/6 抑制剂耐药性,确定 STAT3 为 HR+/HER2 阴性转移性乳腺癌的靶点

Kettner Nicole M, Bui Tuyen N, Navarro-Yepes Juliana, Ghotbaldini Sanaz, Quintela Bethanie, Luo Catherine K, Lam Nghi, Rao Xiayu, Raghavendra Akshara Singareeka, Wang Yan, Azizian Nancy, Kris Eckols T, Kasembeli Moses Makokha, Evans Kurt, Yi Min, Wingate Hannah, Wang Jing, Sahin Aysegul A, Meric-Bernstam Funda, Hunt Kelly K, Damodaran Senthil, Tweardy David J, Tripathy Debu, Keyomarsi Khandan

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

选择性抑制经典 STAT3 信号传导可抑制 K-ras 突变肺肿瘤的发生,并重新激发抗肿瘤免疫力

Clowers Michael J, Rahal Zahraa, Cho Sung-Nam, Krishna Avantika, Yuan Bo, Hamana Zorrilla Leticia G, Eckols T Kris, Kasembeli Moses M, Liu Samuel, Peng Stephen, Ramos-Castaneda Marco, Thompson Annamarie L, Rodriguez Reyna Carlos Ignacio, Larsen Katherine E, Grimaldo Maria T, Deng Shanshan, Karimi Nastaran, Chou Cody, Velasco Walter V, Zarghooni Melody, Alekseev Sayan, Solis Soto Luisa M, Ostrin Edwin J, Kadara Humam, Ekmekcioglu Suhendan, Tweardy David J, Moghaddam Seyed Javad

Update on Structure and Function of SH2 Domains: Mechanisms and Emerging Targeting Strategies

SH2结构域的结构和功能研究进展:机制和新兴靶向策略

Kasembeli, Moses M; Rodas, Jorge; Tweardy, David J

STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer

STAT3抑制剂治疗溃疡性结肠炎相关结直肠癌

Robinson, Prema; Italia, Zal; Italia, Zara; Hoang, Tan; Rodriguez, Emma; Eckols, T Kris; Kasembeli, Moses; Zorrilla, Leticia Hamana; Soto, Luisa Maren Solis; Mahalingam, Rajasekaran; Tweardy, David J

Measuring electrophysiological changes induced by sub-concussive impacts due to soccer ball heading

测量足球头球造成的亚脑震荡冲击引起的电生理变化

Brookshire, Geoffrey; Pennati, Angelo; Yoder, Keith J; Tweardy, MacKenzie; Quirk, Colin; Perkins, Marilyn; Gerrol, Spencer; Raethel, Steven; Nikjou, Devin; Nikolova, Simona; Leonard, Michael; Crepeau, Amy; Dodick, David W; Schwedt, Todd J; Lucero, Ché

Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers

致病性 STAT3 突变蛋白的异常功能与单体和同型二聚体的稳定性改变有关

Moses M Kasembeli, Efiyenia Kaparos, Uddalak Bharadwaj, Ahmad Allaw, Alain Khouri, Bianca Acot, David J Tweardy

Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis

小分子 STAT3 抑制剂在小鼠结肠炎模型中的治疗潜力

Prema Robinson, Kelsey Montoya, Emily Magness, Emma Rodriguez, Viviana Villalobos, Nikita Engineer, Peng Yang, Uddalak Bharadwaj, Thomas Kris Eckols, David John Tweardy

Detection and Monitoring of Viral Infections via Wearable Devices and Biometric Data

利用可穿戴设备和生物识别数据检测和监测病毒感染

Goergen, Craig J; Tweardy, MacKenzie J; Steinhubl, Steven R; Wegerich, Stephan W; Singh, Karnika; Mieloszyk, Rebecca J; Dunn, Jessilyn

Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease

非酒精性脂肪肝肝纤维化进展中 STAT3 激活的空间分子和细胞决定因素

Jingjing Jiao, Jessica I Sanchez, Omar A Saldarriaga, Luisa M Solis, David J Tweardy, Dipen M Maru, Heather L Stevenson, Laura Beretta