日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I Trial of TTI-101, a First-in-Class Oral Inhibitor of STAT3, in Patients with Advanced Solid Tumors

TTI-101(一种首创的口服STAT3抑制剂)治疗晚期实体瘤患者的I期临床试验

Tsimberidou, Apostolia M; Vining, David J; Arora, Sukeshi P; de Achaval, Sofia; Larson, Jeffrey; Kauh, John; Cartwright, Carrie; Avritscher, Rony; Alibhai, Imran; Tweardy, David J; Kaseb, Ahmed O

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer.

IL-6 预测 CDK4/6 抑制剂耐药性,确定 STAT3 为 HR+/HER2 阴性转移性乳腺癌的靶点

Kettner Nicole M, Bui Tuyen N, Navarro-Yepes Juliana, Ghotbaldini Sanaz, Quintela Bethanie, Luo Catherine K, Lam Nghi, Rao Xiayu, Raghavendra Akshara Singareeka, Wang Yan, Azizian Nancy, Kris Eckols T, Kasembeli Moses Makokha, Evans Kurt, Yi Min, Wingate Hannah, Wang Jing, Sahin Aysegul A, Meric-Bernstam Funda, Hunt Kelly K, Damodaran Senthil, Tweardy David J, Tripathy Debu, Keyomarsi Khandan

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

选择性抑制经典 STAT3 信号传导可抑制 K-ras 突变肺肿瘤的发生,并重新激发抗肿瘤免疫力

Clowers Michael J, Rahal Zahraa, Cho Sung-Nam, Krishna Avantika, Yuan Bo, Hamana Zorrilla Leticia G, Eckols T Kris, Kasembeli Moses M, Liu Samuel, Peng Stephen, Ramos-Castaneda Marco, Thompson Annamarie L, Rodriguez Reyna Carlos Ignacio, Larsen Katherine E, Grimaldo Maria T, Deng Shanshan, Karimi Nastaran, Chou Cody, Velasco Walter V, Zarghooni Melody, Alekseev Sayan, Solis Soto Luisa M, Ostrin Edwin J, Kadara Humam, Ekmekcioglu Suhendan, Tweardy David J, Moghaddam Seyed Javad

Update on Structure and Function of SH2 Domains: Mechanisms and Emerging Targeting Strategies

SH2结构域的结构和功能研究进展:机制和新兴靶向策略

Kasembeli, Moses M; Rodas, Jorge; Tweardy, David J

STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer

STAT3抑制剂治疗溃疡性结肠炎相关结直肠癌

Robinson, Prema; Italia, Zal; Italia, Zara; Hoang, Tan; Rodriguez, Emma; Eckols, T Kris; Kasembeli, Moses; Zorrilla, Leticia Hamana; Soto, Luisa Maren Solis; Mahalingam, Rajasekaran; Tweardy, David J

Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn's Disease

克罗恩病小鼠模型中 Stat3 的基因和小分子调控

Robinson, Prema; Magness, Emily; Montoya, Kelsey; Engineer, Nikita; Eckols, Thomas K; Rodriguez, Emma; Tweardy, David J

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

靶向 Janus 激酶和信号转导及转录激活因子 3 治疗炎症、纤维化和癌症:理论基础、进展和注意事项

Bharadwaj, Uddalak; Kasembeli, Moses M; Robinson, Prema; Tweardy, David J

Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors

利用有机和有机-无机杂化抑制剂靶向STAT3抗凋亡通路

Minus, Matthew B; Wang, Haopei; Munoz, Jaime O; Stevens, Alexandra M; Mangubat-Medina, Alicia E; Krueger, Michael J; Liu, Wei; Kasembeli, Moses M; Cooper, Julian C; Kolosov, Mikhail I; Tweardy, David J; Redell, Michele S; Ball, Zachary T

Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer

在帕博西尼耐药的ER阳性乳腺癌中,STAT3和DNA修复的联合抑制

Kettner, Nicole M; Vijayaraghavan, Smruthi; Durak, Merih Guray; Bui, Tuyen; Kohansal, Mehrnoosh; Ha, Min Jin; Liu, Bin; Rao, Xiayu; Wang, Jing; Yi, Min; Carey, Jason P W; Chen, Xian; Eckols, T Kris; Raghavendra, Akshara S; Ibrahim, Nuhad K; Karuturi, Meghan Sri; Watowich, Stephanie S; Sahin, Aysegul; Tweardy, David J; Hunt, Kelly K; Tripathy, Debu; Keyomarsi, Khandan

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

更正:小分子抑制剂对放射抗性头颈部鳞状细胞癌中 STAT3 的抑制作用

Bharadwaj, Uddalak; Eckols, T Kris; Xu, Xuejun; Kasembeli, Moses M; Chen, Yunyun; Adachi, Makoto; Song, Yongcheng; Mo, Qianxing; Lai, Stephen Y; Tweardy, David J