日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation

一种用于递送治疗性纳米抗体以缓解胃肠道炎症的酵母合成生物平台

Palou, Roger; van der Sloot, Almer M; Fiebig, Aline A; Zangara, Megan T; Sangwan, Naseer; Sánchez-Osuna, María; Ilyas, Bushra; Zubyk, Haley; Cook, Michael; Wright, Gerard D; Coombes, Brian K; Tyers, Mike

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

化学-遗传相互作用矩阵揭示药物机制和遗传结构

Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Huard, Caroline; Chatr-Aryamontri, Andrew; St-Cyr, Daniel J; Sánchez-Osuna, María; Papadopoli, David; Normandin, Karine; Paydar, Mohammadjavad; McLaughlan, Shannon; St-Denis, Corinne; Zhang, Li; Say, Henry; Palou, Roger; Stark, Chris; Breitkreutz, Bobby-Joe; van der Sloot, Almer M; Manohar, Sandhya; Lavoie, Hugo; Borden, Katherine L B; Raught, Brian; D'Amours, Damien; Sicheri, Frank; Verreault, Alain; Mader, Sylvie; Meloche, Sylvain; Therrien, Marc; Thibault, Pierre; Wilhelm, Brian; Dirks, Peter B; Aitchison, John D; Patton, Elizabeth; King, Randall W; Roux, Philippe P; Sauvageau, Guy; Hoang, Trang; Marinier, Anne; Harrington, Lea; Kwok, Benjamin; Archambault, Vincent; Topisirovic, Ivan; Tyers, Mike

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.

PRMT5 通过抑制多个近端内含子多聚腺苷酸化位点来促进全长 HTT 表达

Yadav Manisha, AlQazzaz Mona A, Ciamponi Felipe E, Ho Jolene C, Maron Maxim I, Sababi Aiden M, MacLeod Graham, Ahmadi Moloud, Bullivant Garrett, Tano Vincent, Langley Sarah R, Sánchez-Osuna María, Sachamitr Patty, Kushida Michelle, Bardile Costanza Ferrari, Pouladi Mahmoud A, Kurtz Rebecca, Richards Laura, Pugh Trevor, Tyers Mike, Angers Stephane, Dirks Peter B, Bader Gary D, Truant Ray, Massirer Katlin B, Barsyte-Lovejoy Dalia, Shechter David, Harding Rachel J, Arrowsmith Cheryl H, Prinos Panagiotis

De novo design of potent inhibitors of clostridial family toxins

从头设计高效梭菌毒素抑制剂

Ragotte, Robert J; Liang, Huazhu; Tam, John; Miletic, Sean; Berman, Jacob M; Palou, Roger; Weidle, Connor; Li, Zhijie; Glögl, Matthias; Beilhartz, Greg L; Carr, Kenneth D; Borst, Andrew J; Coventry, Brian; Wang, Xinru; Rubinstein, John L; Tyers, Mike; Schramek, Daniel; Melnyk, Roman A; Baker, David

Swi4-dependent SWI4 transcription couples cell size to cell cycle commitment.

Swi4 依赖的 SWI4 转录将细胞大小与细胞周期决定联系起来

Goswami Pooja, Ghimire Abhishek, Coffin Carleton, Cheng Jing, Coulombe-Huntington Jasmin, Ghazal Ghada, Thattikota Yogitha, Guerra María Florencia, Tyers Mike, Tollis Sylvain, Royer Catherine A

Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.

经基因工程改造的分泌亚精胺的布拉氏酵母菌可改善小鼠的结肠炎和结肠癌

Mohaqiq Mahdi, Palou Roger, Li Ruizhen, Zhang Guijun, Vaishnav Het, Parweez Florance, Moyana Terence, Carragher Damian, Cameron D W, Ramsay Timothy, van der Sloot Almer M, Murthy Sanjay, Coombes Brian K, Tyers Mike, Liu X Johné

Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster

经基因工程改造的分泌亚精胺的布拉氏酵母菌可增强果蝇的嗅觉记忆。

Parweez, Florance; Palou, Roger; Li, Ruizhen; Kadhim, Lanna; MacMillan, Heath; Tyers, Mike; Liu, X Johné

The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition

支架蛋白PRR14L将PP2A-TACC3轴与有丝分裂的准确性和对MPS1抑制的敏感性联系起来。

Liu, Albert Z; Narkar, Akshay; Li, Keming; Bertomeu, Thierry; Johnson, Blake A; Coulombe-Huntington, Jasmin; Dong, Yi; Zhu, Jin; Tyers, Mike; Li, Rong

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia

囊泡运输是急性髓系白血病中他汀类药物反应的关键决定因素。

Krosl, Jana; Bordeleau, Marie-Eve; Moison, Céline; MacRae, Tara; Boivin, Isabel; Mayotte, Nadine; Gracias, Deanne; Baccelli, Irène; Lavallée, Vincent-Philippe; Bisaillon, Richard; Lehnertz, Bernhard; Mendoza-Sanchez, Rodrigo; Ruel, Réjean; Bertomeu, Thierry; Coulombe-Huntington, Jasmin; Boucher, Geneviève; Noronha, Nandita; Pabst, Caroline; Tyers, Mike; Gendron, Patrick; Lemieux, Sébastien; Barabé, Frédéric; Marinier, Anne; Hébert, Josée; Sauvageau, Guy

What programs the size of animal cells?

动物细胞的大小由什么因素决定?

Liu, Shixuan; Tan, Ceryl; Tyers, Mike; Zetterberg, Anders; Kafri, Ran