日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

缺氧诱导中性粒细胞祖细胞中组蛋白剪切和H3K4me3丢失,导致中性粒细胞免疫功能长期受损。

Manuel A Sanchez-Garcia ,Pranvera Sadiku # ,Brian M Ortmann # ,Niek Wit # ,Yutaka Negishi # ,Patricia Coelho ,Ailiang Zhang ,Chinmayi Pednekar ,Andrew J M Howden ,David M Griffith ,Rachel Seear ,Jessica D Kindrick ,Janine Mengede ,George Cooper ,Tyler Morrison ,Emily R Watts ,Benjamin T Shimeld ,Leila Reyes ,Ananda S Mirchandani ,Simone Arienti ,Xiang Xu ,Alexander Thomson ,Alejandro J Brenes ,Helena A Turton ,Rebecca Dowey ,Rebecca C Hull ,Hazel Davidson-Smith ,Amy McLaren ,Andrew Deans ,Gourab Choudhury ,Katherine Doverman ,David Hope ,Oliver Vick ,Alastair Woodhead ,Isla Petrie ,Suzanne Green ,Nina M Rzechorzek ,Lance Turtle ,Peter J M Openshaw ,Malcolm G Semple ,J Kenneth Baillie ,Alfred A R Thompson ,David R Mole ,Alex von Kriegsheim ,Moira K B Whyte ,Musa M Mhlanga ,James A Nathan ,Sarah R Walmsley

Virus Log Reduction Values and Dominant Mechanisms in Full-Scale Secondary Biological Wastewater Treatment Systems

全尺寸二级生物污水处理系统中病毒对数减少值和主要机制

Wang, Phillip; Hill, Tyler; Morrison, Christina; Crank, Katherine; Batista, Jacimaria; Gerrity, Daniel

Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function

氧传感酶 PHD1 和 PHD3 在调节中性粒细胞代谢和功能中的不同作用

Emily Watts, Joseph Willison, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Manuel Sanchez-Garcia, Ailiang Zhang, Fiona Murphy, Rebecca Dickinson, Ananda Mirchandani, Tyler Morrison, Amy Lewis, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Massimilliano Mazzone, Patrick Maxwell, Christophe

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

缺氧会影响肺损伤中的免疫环境,并促进炎症持续存在。

Ananda S Mirchandani ,Stephen J Jenkins # ,Calum C Bain # ,Manuel A Sanchez-Garcia ,Hannah Lawson ,Patricia Coelho ,Fiona Murphy ,David M Griffith ,Ailiang Zhang ,Tyler Morrison ,Tony Ly ,Simone Arienti ,Pranvera Sadiku ,Emily R Watts ,Rebecca S Dickinson ,Leila Reyes ,George Cooper ,Sarah Clark ,David Lewis ,Van Kelly ,Christos Spanos ,Kathryn M Musgrave ,Liam Delaney ,Isla Harper ,Jonathan Scott ,Nicholas J Parkinson ,Anthony J Rostron ,J Kenneth Baillie ,Sara Clohisey ,Clare Pridans ,Lara Campana ,Philip Starkey Lewis ,A John Simpson ,David H Dockrell ,Jürgen Schwarze ,Nikhil Hirani ,Peter J Ratcliffe ,Christopher W Pugh ,Kamil Kranc ,Stuart J Forbes ,Moira K B Whyte ,Sarah R Walmsley

Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle

通过甘油 3-磷酸穿梭产生的线粒体 ROS 增强了中性粒细胞 HIF-1α 的稳定性

Joseph A Willson, Simone Arienti, Pranvera Sadiku, Leila Reyes, Patricia Coelho, Tyler Morrison, Giulia Rinaldi, David H Dockrell, Moira K B Whyte, Sarah R Walmsley

Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

中性粒细胞通过糖异生和糖原生成为有效的免疫反应提供能量。

Pranvera Sadiku ,Joseph A Willson ,Eilise M Ryan ,David Sammut ,Patricia Coelho ,Emily R Watts ,Robert Grecian ,Jason M Young ,Martin Bewley ,Simone Arienti ,Ananda S Mirchandani ,Manuel A Sanchez Garcia ,Tyler Morrison ,Ailing Zhang ,Leila Reyes ,Tobias Griessler ,Privjyot Jheeta ,Gordon G Paterson ,Christopher J Graham ,John P Thomson ,Kenneth Baillie ,A A Roger Thompson ,Jessie-May Morgan ,Abel Acosta-Sanchez ,Veronica M Dardé ,Jordi Duran ,Joan J Guinovart ,Gio Rodriguez-Blanco ,Alex Von Kriegsheim ,Richard R Meehan ,Massimiliano Mazzone ,David H Dockrell ,Bart Ghesquiere ,Peter Carmeliet ,Moira K B Whyte ,Sarah R Walmsley

Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

缺氧驱动小鼠中性粒细胞清除蛋白质以维持中心碳代谢

Emily R Watts ,Andrew Jm Howden ,Tyler Morrison ,Pranvera Sadiku ,Jens Hukelmann ,Alex von Kriegsheim ,Bart Ghesquiere ,Fiona Murphy ,Ananda S Mirchandani ,Duncan C Humphries ,Robert Grecian ,Eilise M Ryan ,Patricia Coelho ,Gio Rodriguez Blanco ,Tracie M Plant ,Rebecca S Dickinson ,Andy Finch ,Wesley Vermaelen ,Doreen A Cantrell ,Moira K Whyte ,Sarah R Walmsley

-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--

-------I 型干扰素、促血栓性高炎症中性粒细胞特征在 COVID-19 ARDS 中具有明显特征--

Leila Reyes #, Manuel A Sanchez-Garcia #, Tyler Morrison #, Andy J M Howden #, Emily R Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S Mirchandani, Ailiang Zhang, David Hope, Sarah K Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max H

Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

信号素3F信号通路可主动将中性粒细胞滞留在炎症部位。

Tracie Plant ,Suttida Eamsamarng ,Manuel A Sanchez-Garcia ,Leila Reyes ,Stephen A Renshaw ,Patricia Coelho ,Ananda S Mirchandani ,Jessie-May Morgan ,Felix E Ellett ,Tyler Morrison ,Duncan Humphries ,Emily R Watts ,Fiona Murphy ,Ximena L Raffo-Iraolagoitia ,Ailiang Zhang ,Jenna L Cash ,Catherine Loynes ,Philip M Elks ,Freek Van Eeden ,Leo M Carlin ,Andrew Jw Furley ,Moira Kb Whyte ,Sarah R Walmsley

The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line

合成的苔藓抑素类似物 Merle 23 剖析了 LNCaP 人类前列腺癌细胞系中苔藓抑素活性的不同机制

Noemi Kedei, Andrea Telek, Alexandra Czap, Emanuel S Lubart, Gabriella Czifra, Dazhi Yang, Jinqiu Chen, Tyler Morrison, Paul K Goldsmith, Langston Lim, Poonam Mannan, Susan H Garfield, Matthew B Kraft, Wei Li, Gary E Keck, Peter M Blumberg