日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CDK4/6 inhibition overcomes venetoclax resistance mechanisms with enhanced combination activity in acute myeloid leukemia.

CDK4/6 抑制剂可克服维奈托克耐药机制,增强其在急性髓系白血病中的联合治疗活性。

Stewart Melissa L, Gibbs Jessica, Watanabe-Smith Kevin, Nguyen Ariel, Kenna Isabel, Thiel-Klare Karina, Kaempf Andy, Bottomly Daniel, Kurtz Stephen E, Eide Christopher A, Long Nicola, Saultz Jennifer N, Sax Luca, Huang Ariane, McWeeney Shannon K, Chang Bill H, Tyner Jeffrey W

Biomedical Data Manifest: A lightweight data documentation mapping to increase transparency for AI/ML

生物医学数据清单:一种轻量级的数据文档映射,旨在提高人工智能/机器学习的透明度

Bottomly, Daniel; Suciu, Christopher G; Cordier, Benjamin; Evans, Nathaniel; Poire, Alfonso; Zheng, Christina; Tyner, Jeffrey W; Hutson, Alan; McWeeney, Shannon K

DDX41-Mutated AML: A Case Report and Perspectives

DDX41突变型急性髓系白血病:病例报告及展望

Yashar, William M; Eide, Christopher A; Kurtz, Stephen E; Long, Nicola; Johnson, Kara J; Tognon, Cristina E; Druker, Brian J; Tyner, Jeffrey W; Swords, Ronan

Results of a phase 1 trial testing ruxolitinib plus venetoclax in patients with relapsed/refractory acute myeloid leukemia

一项评估鲁索替尼联合维奈托克治疗复发/难治性急性髓系白血病患者的1期临床试验结果

Borate, Uma; Tognon, Cristina E; Madanat, Yazan F; Misra, Shikha; Kaempf, Andy; Patel, Prapti A; Davis, Kara L; Sun, Junwei; Stuani, Lucille; Eisenmann, Eric D; Eide, Christopher A; Kurtz, Stephen E; Watanabe-Smith, Kevin; Johnson, Kara; Jager, Astraea; Gullaksen, Stein-Erik; Robinson, Bridget; Vu, Tania; Plevritis, Sylvia K; Baker, Sharyn D; Minnier, Jessica; Clement, Peter; Avaylon, Sammantha; Hayes, Madison; Newell, Laura F; Gandhi, Arpita P; Leonard, Jessica; Hayes-Lattin, Brandon; Vasu, Sumithira; Cook, Rachel J; Meyers, Gabrielle; Maziarz, Richard T; Traer, Elie; Swords, Ronan; Tyner, Jeffrey W; Druker, Brian J; Saultz, Jennifer N

Acquired resistance in cancer: towards targeted therapeutic strategies

癌症获得性耐药:迈向靶向治疗策略

Soragni, Alice; Knudsen, Erik S; O'Connor, Thomas N; Tognon, Cristina E; Tyner, Jeffrey W; Gini, Beatrice; Kim, Donghwa; Bivona, Trever G; Zang, Xingxing; Witkiewicz, Agnieszka K; Goodrich, David W; Jiang, Dadi; Gammon, Seth T; Willey, Christopher D; Boutros, Paul C; Sandulache, Vlad C; Osman, Abdullah A; Myers, Jeffrey N; Mehla, Kamiya; Singh, Pankaj K; Chan, Keith S; Gao, Hongbo; Marathe, Himangi

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML

新型 BCL-xL 降解剂 DT2216 在 JAK2 突变型 MPN 后 AML 临床前模型中的疗效

Wang, Zhe; Skwarska, Anna; Poigaialwar, Gowri; Chaudhry, Sovira; Rodriguez-Meira, Alba; Sui, Pinpin; Olivier, Emmanuel; Jia, Yannan; Gupta, Varun; Fiskus, Warren; Ramage, Cassandra L; Zheng, Guangrong; Schurer, Alexandra; Gritsman, Kira; Papapetrou, Eirini P; Bhalla, Kapil; Zhou, Daohong; Mead, Adam J; Rampal, Raajit K; Tyner, Jeffrey W; Abbas, Hussein A; Pemmaraju, Naveen; Tatarata, Qi Zhang; Konopleva, Marina

A CEBPB/IL-1β/TNF-α feedback loop drives drug resistance to venetoclax and MDM2 inhibitors in monocytic leukemia

CEBPB/IL-1β/TNF-α反馈环路驱动单核细胞白血病对维奈托克和MDM2抑制剂的耐药性

Allen, Basil; Bottomly, Daniel; Köhnke, Thomas; Wang, Anthony; Lin, Hsin-Yun; Johnson, Kara; Kenna, Isabel; Streltsova, Anastatia; Martin, Emma; Chen, Reid; Savoy, Lindsey; Long, Nicola; Ryabinin, Peter; Kurtz, Stephen E; Eide, Christopher A; Carlos, Amy; Kaempf, Andy; Liu, Tingting; Tognon, Cristina; Searles, Robert; Piehowski, Paul D; Gosline, Sara J C; Agarwal, Anupriya; Chang, Bill H; Barton, Michelle; Druker, Brian J; McWeeney, Shannon K; Majeti, Ravindra; Tyner, Jeffrey W; Zhang, Haijiao

Genetic and Phenotypic Correlates of Clinical Outcomes with Venetoclax in Acute Myeloid Leukemia: The GEN-PHEN-VEN Study

维奈托克治疗急性髓系白血病临床结局的遗传和表型相关性:GEN-PHEN-VEN 研究

Lachowiez, Curtis A; Heiblig, Mael; Aspas Requena, Gaspar; Tavernier-Tardy, Emmanuelle; Dai, Fangyan; Ashango, Amenech B; Peters, Daniel T; Fang, Jacob; Kaempf, Andy; Long, Nicola; Eide, Christopher A; Kurtz, Stephen E; Xie, Wei; Agarwal, Anupriya; Sahasrabudhe, Aishwarya; McMahon, Christine M; Amaya, Maria L; Meyers, Gabrielle; Gandhi, Arpita; Leonard, Jessica; Hayes-Lattin, Brandon; Maziarz, Richard T; Traer, Elie; Cook, Rachel J; Swords, Ronan; Braun, Theodore P; Saultz, Jennifer N; Eckel, Ashley M; Loken, Michael R; Zeidner, Joshua F; Tyner, Jeffrey W; Pollyea, Daniel A

Oncogenic NTRK3 mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia

致癌性 NTRK3 突变在急性髓系白血病患者中对原肌球蛋白受体激酶抑制剂表现出不同的敏感性。

Joshi, Sunil K; Huang, Ariane; Pittsenbarger, Janét; Shinde, Ujwal; Posso, Camilo; Piehowski, Paul D; Gosline, Sara J C; Press, Richard D; Gritsenko, Marina A; Hutchinson, Chelsea; Weitz, Karl K; Watanabe-Smith, Kevin; Long, Nicola; Rodland, Karin D; Tyner, Jeffrey W; Druker, Brian J; Tognon, Cristina E

The aryl hydrocarbon receptor is associated with monocytic AML and innate immune resistance reversible with an AHR inhibitor.

芳烃受体与单核细胞性急性髓系白血病和先天性免疫抵抗有关,而这种抵抗可以通过 AHR 抑制剂逆转。

Saultz Jennifer N, Bottomly Daniel, Burns Faith, Byrd Kaelan, Kosaka Yoko, Alber Bernhard, Chandra Daniel, Kurtz Stephen E, Fan Guang, Kaempf Andy, Long Nicola, Sanchez-Martin Marta, Wang Lei, McGovern Karen, Kaufman Dan S, McWeeney Shannon K, Druker Brian J, Tyner Jeffrey W, Lind Evan F