日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrative epigenetics and transcriptomics identify aging genes in human blood

整合表观遗传学和转录组学鉴定人类血液中的衰老基因

Moqri, Mahdi; Ying, Kejun; Poganik, Jesse R; Herzog, Chiara; Chen, Qingwen; Emamifar, Mehrnoosh; Tyshkovskiy, Alexander; Eames, Alec; Mur, Jure; Glubokov, Dmitrii; Matei-Dediu, Benyamin; Goeminne, Ludger; Mitchell, Wayne; McCartney, Daniel L; Salas, Lucas A; Marioni, Riccardo E; Lasky-Su, Jessica A; Snyder, Michael P; Gladyshev, Vadim N

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

体内化学重编程与脂滴毒性积累有关,阻碍细胞再生

Mitchell, Wayne; de Magalhães, Cecília G; Tyshkovskiy, Alexander; Uchida, Yushi; Goeminne, Ludger J E; Ichimura, Takaharu; Ng, Emery L; Moldakozhayev, Alibek; Bonventre, Joseph V; Gladyshev, Vadim N

Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations

SIRT6丝氨酸10磷酸化位点突变小鼠的DNA修复、LINE1抑制和寿命之间的平衡

Zhang, Zhihui; Simon, Matthew; Liang, Yuan; Tyshkovskiy, Alexander; Kaplan, Mila; Paige, Victoria; Biashad, Seyed Ali; Gladyshev, Vadim; Seluanov, Andrei; Gorbunova, Vera

Invigorating discovery and clinical translation of aging biomarkers

促进衰老生物标志物的发现和临床转化

Jacques, Erik; Herzog, Chiara; Ying, Kejun; Tomusiak, Alan; Kasamoto, Jessica; Sehgal, Raghav; Paulson, Seth; Reinhard, Julian; Träuble, Jakob; Hastings, Waylon J; Tyshkovskiy, Alexander; Hägg, Sara; Earls, John C; Behrens, Christian E; Lasky-Su, Jessica; Zhou, Gavin; Morgen, Eric; Tsang, John S; Marioni, Riccardo E; Ma, Xiao-Jun; Stolzing, Alexandra; Glorioso, Christin; Gootenberg, Jonathan S; Abudayyeh, Omar O; Argentieri, M Austin; Mak, Raymond H; Cox, Lynne S; Brack, Andrew S; Lauc, Gordan; Furman, David; Buenrostro, Jason D; Schumacher, Björn; Justice, Jamie N; Woods, Tina; Gobel, David; Perez, Viviana I; Sinclair, David A; Maier, Andrea B; Barzilai, Nir; Snyder, Michael P; Wyss-Coray, Tony; Horvath, Steve; Ferrucci, Luigi; Poganik, Jesse R; Moqri, Mahdi; Gladyshev, Vadim N

A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan.

小鼠的类似蛰伏的状态会减缓血液表观遗传衰老,延长健康寿命

Jayne Lorna, Lavin-Peter Aurora, Roessler Julian, Tyshkovskiy Alexander, Antoszewski Mateusz, Ren Erika, Markovski Aleksandar, Sun Senmiao, Yao Hanqi, Sankaran Vijay G, Gladyshev Vadim N, Brooke Robert T, Horvath Steve, Griffith Eric C, Hrvatin Sinisa

The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age

靶向线粒体的肽类治疗药物Elamipretide可在不引起组织表观遗传或转录组年龄可检测变化的情况下,改善衰老过程中的心肌和骨骼肌功能。

Mitchell, Wayne; Pharaoh, Gavin; Tyshkovskiy, Alexander; Campbell, Matthew; Marcinek, David J; Gladyshev, Vadim N

Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health

IR或IGF1R基因突变可使小鼠表现出长寿的特征,同时维持其代谢健康。

Hernández-Arciga, Ulalume; Kim, Jun Kyoung; Fisher, Jacob L; Tyshkovskiy, Alexander; Moldakozhayev, Alibek; Hall, Catherine; Ghosh, Souvik; Govindaraj, Yashvandhini; Sipula, Ian J; Kastroll, Jake; Cooke, Diana; Luo, Jinping; Alder, Jonathan K; Rizzo, Stacey J Sukoff; Ables, Gene P; Choi, Eunhee; Gladyshev, Vadim N; Jurczak, Michael J; Tatar, Marc; Parkhitko, Andrey A

In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation

体内化学重编程与脂滴的毒性积累有关,从而阻碍细胞再生。

Mitchell, Wayne; de Magalhães, Cecília G; Tyshkovskiy, Alexander; Uchida, Yushi; Goeminne, Ludger J E; Ichimura, Takaharu; Ng, Emery L; Bonventre, Joseph V; Gladyshev, Vadim N

Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model

在纵向异时移植模型中实现白色脂肪组织的再生

Moldakozhayev, Alibek; Tyshkovskiy, Alexander; Nigro, Pasquale; de Magalhães, Cecília G; Ying, Kejun; Eames, Alec W; Poganik, Jesse R; Tskhay, Albina; Zhang, Bohan; Tikhonov, Stanislav; Anekal, Praju Vikas; Carbone, Nicholas P; Hirshman, Michael F; Goodyear, Laurie J; Van Raamsdonk, Jeremy M; Gladyshev, Vadim N

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

重编程因子激活非经典氧化恢复通路,该通路能够使视网膜色素上皮细胞再生并恢复视力。

Lu, Yuancheng Ryan; Cameron, James C; Hu, Yan; Shen, Han; Shirahama, Shintaro; Tyshkovskiy, Alexander; Chen, Zhaoyi; Ai, Jiahe; Zhu, Daniel Y; Karg, Margarete M; Chew, Lindsey A; Bell, George W; Jena, Siddhartha G; He, Yue; Seifert, Philip; Shu, Daisy Y; Ei-Brolosy, Mohamed A; Lou, Qiannuo; Zhang, Bohan; Puszynska, Anna M; Qiu, Xiaojie; Tian, Xiao; Gregory-Ksander, Meredith; Gladyshev, Vadim N; Sinclair, David A; Saint-Geniez, Magali; Buenrostro, Jason D; Rickman, Catherine Bowes; Ksander, Bruce R; Weissman, Jonathan S