A Rationally Designed Novel Bifunctional Human TNF-α- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload
一种合理设计的新型双功能人TNF-α和Janus激酶靶向soloMER药物偶联物（SDC），带有中性粒细胞弹性蛋白酶可切割的连接子，可实现有效载荷在炎症部位的特异性释放。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.6c00532
Murray, Euan; Priyanka, Stella; Martinez-Fraile, Julia; Grygorash, Ruslan; Idress, Mohannad; Brownbridge, Luke C; Glavina, Stella; Camper, Nicolas; Boyd, Robert; Porter, Andrew J; Barelle, Caroline J; Ubah, Obinna C
信号转导
中性粒细胞
炎症/感染
Immunology/Inflammation
TNF-α
Human
细胞生物学
炎症
粒细胞
