日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites.

药物再利用方法揭示了间日疟原虫休眠子中可靶向的表观遗传通路

Maher Steven P, Bakowski Malina A, Vantaux Amélie, Flannery Erika L, Andolina Chiara, Gupta Mohit, Antonova-Koch Yevgeniya, Argomaniz Magdalena, Cabrera-Mora Monica, Campo Brice, Chao Alexander T, Chatterjee Arnab K, Cheng Wayne T, Chuenchob Vorada, Cooper Caitlin A, Cottier Karissa, Galinski Mary R, Harupa-Chung Anke, Ji Hana, Joseph Sean B, Lenz Todd, Lonardi Stefano, Matheson Jessica, Mikolajczak Sebastian A, Moeller Timothy, Orban Agnes, Padín-Irizarry Vivian, Pan Kastin, Péneau Julie, Prudhomme Jacques, Roesch Camille, Ruberto Anthony, Sabnis Saniya S, Saney Celia L, Sattabongkot Jetsumon, Sereshki Saleh, Suriyakan Sangrawee, Ubalee Ratawan, Wang Yinsheng, Wasisakun Praphan, Yin Jiekai, Popovici Jean, McNamara Case W, Joyner Chester, Nosten François H, Witkowski Benoît, Le Roch Karine G, Kyle Dennis E

mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice

编码间日疟原虫环子孢子蛋白的mRNA-LNP疫苗具有高度免疫原性,并能为小鼠提供保护。

Limsalakpetch, Amporn; Kum-Arb, Utaiwan; Yongvanitchit, Kosol; Im-Erbsin, Rawiwan; Ubalee, Ratawan; Waters, Norman; Vesely, Brian A; Muramatsu, Hiromi; Weissman, Drew; Tam, Ying K; Yoshida, Shigeto; Adams, John; Yadava, Anjali; Pardi, Norbert; Pichyangkul, Sathit

Superior protection in a relapsing Plasmodium cynomolgi rhesus macaque model by a chemoprophylaxis with sporozoite immunization regimen with atovaquone-proguanil followed by primaquine

在复发性猕猴疟原虫感染模型中,采用阿托伐醌-丙胍联合子孢子免疫方案进行化学预防,随后使用伯氨喹,可获得更优的保护效果。

Yongvanitchit, Kosol; Kum-Arb, Utaiwan; Limsalakpetch, Amporn; Im-Erbsin, Rawiwan; Ubalee, Ratawan; Spring, Michele D; Vesely, Brian A; Waters, Norman; Pichyangkul, Sathit

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

药物重定位策略揭示间日疟原虫休眠子中可靶向的表观遗传通路

Maher, S P; Bakowski, M A; Vantaux, A; Flannery, E L; Andolina, C; Gupta, M; Antonova-Koch, Y; Argomaniz, M; Cabrera-Mora, M; Campo, B; Chao, A T; Chatterjee, A K; Cheng, W T; Chuenchob, E; Cooper, C A; Cottier, K; Galinski, M R; Harupa-Chung, A; Ji, H; Joseph, S B; Lenz, T; Lonardi, S; Matheson, J; Mikolajczak, S A; Moeller, T; Orban, A; Padín-Irizarry, V; Pan, K; Péneau, J; Prudhomme, J; Roesch, C; Ruberto, A A; Sabnis, S S; Saney, C L; Sattabongkot, J; Sereshki, S; Suriyakan, S; Ubalee, R; Wang, Y; Wasisakun, P; Yin, J; Popovici, J; McNamara, C W; Joyner, C J; Nosten, F; Witkowski, B; Le Roch, K G; Kyle, D E

A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, species differentiation, and drug-resistance genotyping

一种基于 CRISPR 的新型疟疾诊断方法,能够检测疟原虫、进行物种区分和耐药性基因分型

Clark H Cunningham, Christopher M Hennelly, Jessica T Lin, Ratawan Ubalee, Ross M Boyce, Edgar M Mulogo, Nicholas Hathaway, Kyaw L Thwai, Fernandine Phanzu, Albert Kalonji, Kashamuka Mwandagalirwa, Antoinette Tshefu, Jonathan J Juliano, Jonathan B Parr

Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes

恶性疟原虫/间日疟原虫混合感染从人类到蚊子的有效传播

Balasubramanian, Sujata; Rahman, Rifat S; Lon, Chanthap; Parobek, Christian; Ubalee, Ratawan; Hathaway, Nicholas; Kuntawunginn, Worachet; My, Mok; Vy, Dav; Saxe, Jeremy; Lanteri, Charlotte; Lin, Feng-Chang; Spring, Michele; Meshnick, Steven R; Juliano, Jonathan J; Saunders, David L; Lin, Jessica T

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

针对间日疟原虫和恶性疟原虫的肝期治疗的综合评估模型

Alison Roth, Steven P Maher, Amy J Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A Kaba, Amélie Vantaux, Malina A Bakowski, Richard Thomson-Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J Barnes, Caitlin A Cooper, Mélanie Rouillier, Case W McNamara, Sebastian A Mikolajczak, N

Unraveling the Plasmodium vivax sporozoite transcriptional journey from mosquito vector to human host

揭示间日疟原虫子孢子从蚊子媒介到人类宿主的转录历程

Alison Roth, Swamy R Adapa, Min Zhang, Xiangyun Liao, Vishal Saxena, Raaven Goffe, Suzanne Li, Ratawan Ubalee, Gagandeep S Saggu, Zarna R Pala, Shilpi Garg, Silas Davidson, Rays H Y Jiang, John H Adams

Strict tropism for CD71(+)/CD234(+) human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi

对CD71(+)/CD234(+)人网织红细胞的严格嗜性限制了猴疟原虫的人畜共患病潜力。

Kosaisavee, Varakorn; Suwanarusk, Rossarin; Chua, Adeline C Y; Kyle, Dennis E; Malleret, Benoit; Zhang, Rou; Imwong, Mallika; Imerbsin, Rawiwan; Ubalee, Ratawan; Sámano-Sánchez, Hugo; Yeung, Bryan K S; Ong, Jessica J Y; Lombardini, Eric; Nosten, François; Tan, Kevin S W; Bifani, Pablo; Snounou, Georges; Rénia, Laurent; Russell, Bruce

Chemoprophylaxis with sporozoite immunization in P. knowlesi rhesus monkeys confers protection and elicits sporozoite-specific memory T cells in the liver

在恒河猴中,用孢子体免疫进行化学预防可提供保护,并在肝脏中诱导产生孢子体特异性记忆T细胞。

Sathit Pichyangkul ,Michele D Spring ,Kosol Yongvanitchit ,Utaiwan Kum-Arb ,Amporn Limsalakpetch ,Rawiwan Im-Erbsin ,Ratawan Ubalee ,Pattaraporn Vanachayangkul ,Edmond J Remarque ,Evelina Angov ,Philip L Smith ,David L Saunders