日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Prediction of Cardiac ATTR Depletion by NI006 (ALXN2220) Using Mechanistic PK/PD Modeling

利用机制性PK/PD模型预测NI006 (ALXN2220)对心脏ATTR的消耗

Michalon, Aubin; Renaud, Lionel; Machacek, Matthias; Cortijo, Cédric; Udata, Chandrasekhar; Mercuri, Michele F; Buller, Fabian; Hock, Christoph; Nitsch, Roger M; Kahr, Peter C; Grimm, Jan

Considerations on the Calculation of the Human Equivalent Dose from Toxicology Studies for Biologic Anticancer Agents

关于利用毒理学研究计算生物抗癌药物人体等效剂量的思考

Elmeliegy, Mohamed; Udata, Chandrasekhar; Liao, Ken; Yin, Donghua

Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes

基于模型的PF-06342674(一种针对IL-7受体α的人源化单克隆抗体)在1型糖尿病成人患者中的药代动力学、靶点结合生物标志物和免疫调节活性表征

Williams, Jason H; Udata, Chandrasekhar; Ganguly, Bishu J; Bucktrout, Samantha L; Joh, Tenshang; Shannon, Megan; Wong, Gilbert Y; Levisetti, Matteo; Garzone, Pamela D; Meng, Xu

A mechanistic pharmacokinetic model with drug and antidrug antibody interplay, and its application for assessing the impact of immunogenicity response on bioequivalence testing

药物与抗药抗体相互作用的机制药代动力学模型及其在评估免疫原性反应对生物等效性试验影响中的应用

Liao, Kai H; Udata, Chandrasekhar; Yin, Donghua; Sewell, K Lea; Kantaridis, Constantino; Alvarez, Daniel F; Meng, Xu

Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes

人源化抗IL-7R单克隆抗体RN168在1型糖尿病患者中的免疫调节活性

Herold, Kevan C; Bucktrout, Samantha L; Wang, Xiao; Bode, Bruce W; Gitelman, Stephen E; Gottlieb, Peter A; Hughes, Jing; Joh, Tenshang; McGill, Janet B; Pettus, Jeremy H; Potluri, Shobha; Schatz, Desmond; Shannon, Megan; Udata, Chandrasekhar; Wong, Gilbert; Levisetti, Matteo; Ganguly, Bishu J; Garzone, Pamela D