日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer

发现和开发高效且选择性的双重NUAK/MARK抑制剂,作为Hippo通路调节剂用于癌症治疗

Smil, David; Liu, Yong; Xin, Tao; Kiyota, Taira; Aman, Ahmed; Grouleff, Julie; Hoffer, Laurent; Joshi, Dhananjay C; Inanlou, Mohammad R; Song, Siyuan; Mao, Daniel Y L; Ogunjimi, Abiodun A; Pau, Victor; Chini, Fiona D; Kurinov, Igor; Zhang, Ying; Nguyen, Anh Thu; Wrana, Jeffrey L; Sicheri, Frank; Attisano, Liliana; Uehling, David; Al-Awar, Rima; Isaac, Methvin B

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Kimani Serah W, Noureldin Mahmoud, Wilson Brian, Hoffer Laurent, Green Stuart R, Szewczyk Magdalena M, González-Álvarez Héctor, Mohammed Mohammed, Chan Manuel, Krausser Chiara, Li Alice Shi Ming, Hajian Taraneh, Tucker Sarah, Joshi Dhananjay, Saraon Punit, Thériault Brigitte, Kim Ji Sup, Santhakumar Vijayaratnam, Loppnau Peter, Li Yanjun, Seitova Almagul, Dong Aiping, Kiyota Taira, Hammann Tobias, Gehrtz Paul, Patel Bhashant, Rathod Vaibhavi, Vala Anand, Rout Bhimsen, Jagodra Paras, Brown Peter J, Aman Ahmed, Ramnauth Jailall, Poda Gennady, Uehling David, Arrowsmith Cheryl H, Barsyte-Lovejoy Dalia, Marcellus Richard, Ackloo Suzanne, Mamai Ahmed, Al-Awar Rima, Halabelian Levon

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor

OICR12694 的发现:一种新型、高效、选择性强且口服生物利用度高的 BCL6 BTB 抑制剂

Mamai, Ahmed; Chau, Anh M; Wilson, Brian J; Watson, Iain D; Joseph, Babu B; Subramanian, Pandiaraju R; Morshed, Monzur M; Morin, Justin A; Prakesch, Michael A; Lu, Tianbao; Connolly, Pete; Kuntz, Douglas A; Pomroy, Neil C; Poda, Gennady; Nguyen, Kong; Marcellus, Richard; Strathdee, Graig; Theriault, Brigitte; Subramaniam, Ratheesh; Mohammed, Mohammed; Abibi, Ayome; Chan, Manuel; Winston, Jeffrey; Kiyota, Taira; Undzys, Elijus; Aman, Ahmed; Austin, Nigel; Du Jardin, Marc; Packman, Kathryn; Phillippar, Ulrike; Attar, Riccardo; Edwards, James; O'Meara, Jeff; Uehling, David E; Al-Awar, Rima; Privé, Gilbert G; Isaac, Methvin B

Small molecules reveal an alternative mechanism of Bax activation

小分子揭示了Bax激活的另一种机制

Brahmbhatt, Hetal; Uehling, David; Al-Awar, Rima; Leber, Brian; Andrews, David

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

达拉非尼的发现:一种选择性Raf激酶抑制剂,对B-Raf驱动的肿瘤具有抗肿瘤活性

Rheault, Tara R; Stellwagen, John C; Adjabeng, George M; Hornberger, Keith R; Petrov, Kimberly G; Waterson, Alex G; Dickerson, Scott H; Mook, Robert A Jr; Laquerre, Sylvie G; King, Alastair J; Rossanese, Olivia W; Arnone, Marc R; Smitheman, Kimberly N; Kane-Carson, Laurie S; Han, Chao; Moorthy, Ganesh S; Moss, Katherine G; Uehling, David E