Ujjayini相关文献与解析，生知库 | 链接生命科学的每一步

Ujjayini Ghosh #, Eric Tse #, Hyunjun Yang, Marie Shi, Christoffer D Caro, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condello

神经

阿尔茨海默症

HTRF

发表日期：2024

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Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold

冷冻电镜结构揭示唐氏综合征患者的tau蛋白丝会折叠成阿尔茨海默病患者的折叠结构。

期刊:

影响因子:

doi:10.1101/2024.04.02.587507

Ghosh, Ujjayini; Tse, Eric; Yang, Hyunjun; Shi, Marie; Carlo, Christoffer D; Wang, Feng; Merz, Gregory E; Prusiner, Stanley B; Southworth, Daniel R; Condello, Carlo

阿尔茨海默症

发表日期：2024

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Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection

HIV gp41融合肽β折叠序列的广泛分布支持其在融合和感染过程中具有突变稳健性

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:

doi:10.1073/pnas.2402953121

Zhang, Yijin; Schmick, Scott D; Xie, Li; Ghosh, Ujjayini; Weliky, David P

Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice

两种结构明确的 Aβ 多态性导致易感小鼠发生不同的病理变化

期刊:EMBO Reports

影响因子:6.5

doi:10.15252/embr.202357003

Ruben Gomez-Gutierrez, Ujjayini Ghosh, Wai-Ming Yau, Nazaret Gamez, Katherine Do, Carlos Kramm, Hamid Shirani, Laura Vegas-Gomez, Jonathan Schulz, Ines Moreno-Gonzalez, Antonia Gutierrez, K Peter R Nilsson, Robert Tycko, Claudio Soto, Rodrigo Morales

信号转导

发表日期：2023

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A large HIV gp41 construct with trimer-of-hairpins structure exhibits V2E mutation-dominant attenuation of vesicle fusion and helicity very similar to V2E attenuation of HIV fusion and infection and supports: (1) hairpin stabilization of membrane apposition with larger distance for V2E; and (2) V2E dominance by an antiparallel β sheet with interleaved fusion peptide strands from two gp41 trimers

一种具有发夹三聚体结构的大型 HIV gp41 构建体表现出 V2E 突变主导的囊泡融合和螺旋性减弱，与 V2E 对 HIV 融合和感染的减弱非常相似，并支持以下观点：(1) 发夹结构稳定膜贴合，V2E 突变导致膜贴合距离增大；(2) V2E 突变主导的是由来自两个 gp41 三聚体的交错融合肽链构成的反平行 β 折叠。

期刊:Biophysical Chemistry

影响因子:2.2

doi:10.1016/j.bpc.2022.106933

Rokonujjaman, Md; Sahyouni, Abdulrazak; Wolfe, Robert; Jia, Lihui; Ghosh, Ujjayini; Weliky, David P

Lipid acyl chain protrusion induced by the influenza virus hemagglutinin fusion peptide detected by NMR paramagnetic relaxation enhancement

流感病毒血凝素融合肽诱导的脂酰链突出可通过核磁共振顺磁弛豫增强法检测

期刊:Biophysical Chemistry

影响因子:2.2

doi:10.1016/j.bpc.2023.107028

Zhang, Yijin; Ghosh, Ujjayini; Xie, Li; Holmes, Daniel; Severin, Kathryn G; Weliky, David P

Structural differences in amyloid-β fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients

非痴呆老年人和阿尔茨海默病患者脑组织中β-淀粉样蛋白原纤维的结构差异

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2111863118

Ghosh, Ujjayini; Yau, Wai-Ming; Collinge, John; Tycko, Robert

Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue

阿尔茨海默病脑组织中一种常见的β-淀粉样蛋白原纤维多晶型物的分子结构

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2023089118

Ghosh, Ujjayini; Thurber, Kent R; Yau, Wai-Ming; Tycko, Robert

Rapid (2)H NMR Transverse Relaxation of Perdeuterated Lipid Acyl Chains of Membrane with Bound Viral Fusion Peptide Supports Large-Amplitude Motions of These Chains That Can Catalyze Membrane Fusion

膜上结合病毒融合肽的全氘代脂质酰基链的快速(2)H NMR横向弛豫支持这些链的大振幅运动，这种运动可以催化膜融合。

期刊:Biochemistry

影响因子:3

doi:10.1021/acs.biochem.1c00316

Ghosh, Ujjayini; Weliky, David P

微生物学

发表日期：2021

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Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS

FUS低复杂度蛋白序列形成的淀粉样原纤维的分子结构和相互作用

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-020-19512-3

Lee, Myungwoon; Ghosh, Ujjayini; Thurber, Kent R; Kato, Masato; Tycko, Robert

FUS

发表日期：2020

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Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold

低温电子显微镜结构揭示唐氏综合症的 tau 蛋白丝呈现阿尔茨海默病的折叠

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold

冷冻电镜结构揭示唐氏综合征患者的tau蛋白丝会折叠成阿尔茨海默病患者的折叠结构。

Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection

HIV gp41融合肽β折叠序列的广泛分布支持其在融合和感染过程中具有突变稳健性

Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice

两种结构明确的 Aβ 多态性导致易感小鼠发生不同的病理变化

Lipid acyl chain protrusion induced by the influenza virus hemagglutinin fusion peptide detected by NMR paramagnetic relaxation enhancement

流感病毒血凝素融合肽诱导的脂酰链突出可通过核磁共振顺磁弛豫增强法检测

Structural differences in amyloid-β fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients

非痴呆老年人和阿尔茨海默病患者脑组织中β-淀粉样蛋白原纤维的结构差异

Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue

阿尔茨海默病脑组织中一种常见的β-淀粉样蛋白原纤维多晶型物的分子结构

Rapid (2)H NMR Transverse Relaxation of Perdeuterated Lipid Acyl Chains of Membrane with Bound Viral Fusion Peptide Supports Large-Amplitude Motions of These Chains That Can Catalyze Membrane Fusion

膜上结合病毒融合肽的全氘代脂质酰基链的快速(2)H NMR横向弛豫支持这些链的大振幅运动，这种运动可以催化膜融合。

Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS

FUS低复杂度蛋白序列形成的淀粉样原纤维的分子结构和相互作用