日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

ESAT-6 在吞噬体 pH 下发生自缔合,ESAT-6 特异性纳米抗体限制结核分枝杆菌在巨噬细胞中的生长

Timothy A Bates, Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse

Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain

通过胞外结构域的丧失对 ROS1 催化激活机制的新见解

Kristen Jones #, Clare Keddy #, Chelsea Jenkins, Katelyn Nicholson, Ujwal Shinde, Monika A Davare

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

ESAT-6 在吞噬体 pH 下发生自缔合,并且 ESAT-6 特异性纳米抗体限制了巨噬细胞中的结核分枝杆菌生长

Timothy A Bates, Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew Ah Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

泛素特异性蛋白酶 USP36 对 EXOSC10 进行 SUMO 化,促进核仁 RNA 外泌体在 rRNA 加工中发挥作用

Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

发现对酪氨酸激酶抑制剂敏感的致癌 ROS1 错义突变

Sudarshan R Iyer #, Kevin Nusser #, Kristen Jones #, Pushkar Shinde, Clare Keddy, Catherine Z Beach, Erin Aguero, Jeremy Force, Ujwal Shinde, Monika A Davare

Resistance Profile and Structural Modeling of Next-Generation ROS1 Tyrosine Kinase Inhibitors

下一代 ROS1 酪氨酸激酶抑制剂的耐药特征和结构建模

Clare Keddy #, Pushkar Shinde #, Kristen Jones, Stefanie Kaech, Romel Somwar, Ujwal Shinde, Monika A Davare

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors

癌症中的 NTRK 激酶结构域突变对 I 型和 II 型抑制剂的敏感性有不同影响

Romel Somwar, Nicolle E Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A Davare

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

抑制白细胞介素-1受体相关激酶-1是治疗急性髓系白血病亚型的策略

Mona M Hosseini, Stephen E Kurtz, Sherif Abdelhamed, Shawn Mahmood, Monika A Davare, Andy Kaempf, Johannes Elferich, Jason E McDermott, Tao Liu, Samuel H Payne, Ujwal Shinde, Karin D Rodland, Motomi Mori, Brian J Druker, Jack W Singer, Anupriya Agarwal

Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance

琥珀酸脱氢酶亚基A未知意义变体的生化、分子和临床特征

Amber E Bannon ,Jason Kent ,Isaac Forquer ,Ajia Town ,Lillian R Klug ,Kelly McCann ,Carol Beadling ,Oliver Harismendy ,Jason K Sicklick ,Christopher Corless ,Ujwal Shinde ,Michael C Heinrich

Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c

蛋白质组学分析和分子建模表征铁调节蛋白血红素/排斥引导分子 c

Mahta Nili, Larry David, Johannes Elferich, Ujwal Shinde, Peter Rotwein