日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer

XTX101是一种肿瘤激活的、Fc增强的抗CTLA-4单克隆抗体,在小鼠癌症模型中表现出肿瘤生长抑制作用和肿瘤选择性药效学。

Kurt A Jenkins ,Miso Park ,Magali Pederzoli-Ribeil ,Ugur Eskiocak ,Parker Johnson ,Wilson Guzman ,Megan McLaughlin ,Deborah Moore-Lai ,Caitlin O'Toole ,Zhen Liu ,Benjamin Nicholson ,Veronica Flesch ,Huawei Qiu ,Tim Clackson ,Ronan C O'Hagan ,Ulrich Rodeck ,Margaret Karow ,Jennifer O'Neil ,John C Williams

Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells

热量限制会损害放射治疗后肿瘤微环境中的调节性T细胞,并启动效应T细胞。

Gregor Manukian ,Charles Kivolowitz ,Tiziana DeAngelis ,Anuradha A Shastri ,Jason E Savage ,Kevin Camphausen ,Ulrich Rodeck ,Jelani C Zarif ,Nicole L Simone

miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas

miRNA 和细胞因子相关的细胞外囊泡介导鳞状细胞癌

Joseph P Flemming, Brianna L Hill, Mohammed W Haque, Jessica Raad, Claudine S Bonder, Larry A Harshyne, Ulrich Rodeck, Adam Luginbuhl, James K Wahl 3rd, Kenneth Y Tsai, Peter J Wermuth, Andrew M Overmiller, Mỹ G Mahoney

A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation

三方合作机制使蛋白激酶A催化亚基对去磷酸化具有抵抗力

Tung O Chan, Roger S Armen, Santosh Yadav, Sushrut Shah, Jin Zhang, Brian C Tiegs, Nikhil Keny, Brian Blumhof, Deepak A Deshpande, Ulrich Rodeck, Raymond B Penn

Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth

肿瘤衍生的细胞外囊泡需要 β1 整合素来促进非锚定依赖性生长

Rachel M DeRita, Aejaz Sayeed, Vaughn Garcia, Shiv Ram Krishn, Christopher D Shields, Srawasti Sarker, Andrea Friedman, Peter McCue, Sudheer Kumar Molugu, Ulrich Rodeck, Adam P Dicker, Lucia R Languino

STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair

STAT5A/B 阻断通过抑制 RAD51 和 DNA 修复使前列腺癌对放射敏感

Cristina Maranto #, Vindhya Udhane #, David T Hoang, Lei Gu, Vitali Alexeev, Kareem Malas, Karmel Cardenas, Jonathan R Brody, Ulrich Rodeck, Carmen Bergom, Ken A Iczkowski, Ken Jacobsohn, William See, Sara M Schmitt, Marja T Nevalainen

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin

小鼠心肌细胞自噬过程中的代谢重编程需要细胞外营养传感器核心蛋白聚糖。

Maria A Gubbiotti ,Erin Seifert ,Ulrich Rodeck ,Jan B Hoek ,Renato V Iozzo

Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts

静止人类成纤维细胞中 ATP 限制引起的不同细胞应激反应

Nirupama Yalamanchili, Andres Kriete, David Alfego, Kelli M Danowski, Csaba Kari, Ulrich Rodeck

Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells

选择性 RAF 抑制剂可抑制突变 NRAS 和维莫非尼耐药黑色素瘤细胞中的 ERK1/2 磷酸化和生长

Kaitlyn Le, Erik S Blomain, Ulrich Rodeck, Andrew E Aplin

Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice

肿瘤坏死因子-α和白细胞介素-1拮抗剂可减轻小鼠表皮生长因子受体抗体治疗相关的炎症性皮肤变化

David Surguladze, Dhanvanthri Deevi, Nidia Claros, Erik Corcoran, Su Wang, Mary Jane Plym, Yan Wu, Jacqueline Doody, David J Mauro, Larry Witte, Klaus J Busam, Bronek Pytowski, Ulrich Rodeck, James R Tonra