日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mitotic MTH1 inhibitor karonudib kills epithelial ovarian cancer independent of platinum sensitivity

有丝分裂抑制剂MTH1 karonudib 可杀死上皮性卵巢癌细胞,且该作用与铂类药物敏感性无关。

Hurley, Rachel M; Wagner, Jill M; Kanakkanthara, Arun; Venkatachalam, Annapoorna; Deisinger, Aaron M; Correia, Cristina; Schneider, Paula A; Peterson, Kevin L; Macon, Elaine P; Heinzen, Ethan P; Sanjiv, Kumar; Hou, Xiaonan; Becker, Marc A; Maurer, Matthew J; Larson, Melissa C; Swisher, Elizabeth M; Li, Hu; Oberg, Ann L; Weroha, S John; Berglund, Ulrika Warpman; Helleday, Thomas; Kaufmann, Scott H; Hendrickson, Andrea E Wahner

Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway

有丝分裂 MTH1 抑制剂 TH1579 通过 cGAS-STING 通路诱导 PD-L1 表达和炎症反应

Jianyu Shen, Emilio Guillén Mancina, Shenyu Chen, Theodora Manolakou, Helge Gad, Ulrika Warpman Berglund, Kumar Sanjiv, Thomas Helleday

The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

一碳代谢酶MTHFD2促进电离辐射后的切除和同源重组

Petra Marttila, Nadilly Bonagas, Christina Chalkiadaki, Hannah Stigsdotter, Korbinian Schelzig, Jianyu Shen, Crystal M Farhat, Amber Hondema, Julian Albers, Elisée Wiita, Azita Rasti, Ulrika Warpman Berglund, Ana Slipicevic, Oliver Mortusewicz, Thomas Helleday

Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming

短期饥饿通过代谢重编程增强三阴性乳腺癌化疗的疗效

Ioannis S Pateras #, Chloe Williams #, Despoina D Gianniou #, Aggelos T Margetis #, Margaritis Avgeris #, Pantelis Rousakis, Aigli-Ioanna Legaki, Peter Mirtschink, Wei Zhang, Konstantina Panoutsopoulou, Anastasios D Delis, Stamatis N Pagakis, Wei Tang, Stefan Ambs, Ulrika Warpman Berglund, Thomas He

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

MTH1作为靶点,可通过选择性抑制活化的T细胞来缓解T细胞驱动的疾病。

Stella Karsten ,Roland Fiskesund ,Xing-Mei Zhang ,Petra Marttila ,Kumar Sanjiv ,Therese Pham ,Azita Rasti ,Lars Bräutigam ,Ingrid Almlöf ,Maritha Marcusson-Ståhl ,Carolina Sandman ,Björn Platzack ,Robert A Harris ,Christina Kalderén ,Karin Cederbrant ,Thomas Helleday ,Ulrika Warpman Berglund

MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells

MutT 同源物 1 抑制剂 Karonudib 通过抑制活化 T 细胞中的 DNA 修复来减轻自身免疫性肝炎

Yong Chen, Xiangwei Hua, Bingyuan Huang, Stella Karsten, Zhengrui You, Bo Li, You Li, Yikang Li, Jubo Liang, Jun Zhang, Yiran Wei, Ruiling Chen, Zhuwan Lyu, Xiao Xiao, Min Lian, Jue Wei, Jingyuan Fang, Qi Miao, Qixia Wang, Ulrika Warpman Berglung, Ruqi Tang, Thomas Helleday, Xiong Ma

Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer

过表达的 c-Myc 使细胞对有丝分裂阻滞和氧化性 DNA 损伤诱导剂 TH1579 敏感

Sofia Henriksson, José Manuel Calderón-Montaño, Daniel Solvie, Ulrika Warpman Berglund, Thomas Helleday

NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis

NEIL3 通过修复有丝分裂期间端粒的氧化损伤来预防肝细胞癌的衰老

Zhenjun Zhao, Helge Gad #, Carlos Benitez-Buelga, Kumar Sanjiv, Hua Xiangwei, He Kang, Mingxuan Feng, Zhicong Zhao #, Ulrika Warpman Berglund, Qiang Xia, Thomas Helleday

A phenomics approach for antiviral drug discovery

抗病毒药物研发的表型组学方法

Jonne Rietdijk, Marianna Tampere, Aleksandra Pettke, Polina Georgiev, Maris Lapins, Ulrika Warpman-Berglund, Ola Spjuth, Marjo-Riitta Puumalainen, Jordi Carreras-Puigvert

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

利用强效抑制剂解析的NUDT15变体晶体结构揭示了硫嘌呤敏感性的结构基础。

Rehling, Daniel; Zhang, Si Min; Jemth, Ann-Sofie; Koolmeister, Tobias; Throup, Adam; Wallner, Olov; Scaletti, Emma; Moriyama, Takaya; Nishii, Rina; Davies, Jonathan; Desroses, Matthieu; Rudd, Sean G; Scobie, Martin; Homan, Evert; Berglund, Ulrika Warpman; Yang, Jun J; Helleday, Thomas; Stenmark, Pål