In vitro and in vivo study of the inhibition of ubiquinone biosynthesis in Leishmania (Leishmania) amazonensis using the combination of buparvaquone and 4-nitrobenzoate as a strategy for the discovery of new therapeutic targets
本研究采用布帕伐醌和4-硝基苯甲酸酯的组合策略,体外和体内研究了抑制亚马逊利什曼原虫(Leishmania (Leishmania) amazonensis)泛醌生物合成的机制,旨在发现新的治疗靶点。
期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.00824-25
Mesquita, Juliana Tonini; Moura, Gabriel Cândido; Cavalcante, Tainá; Yokoyama Yasunaka, Jenicer Kazumi Umada; Peres, Manoel Aparecido; Blanes Angeli, Claudia; Taniwaki, Noemi Nosomi; Simonsen Stolf, Beatriz; Palmisano, Giuseppe; Katzin, Alejandro Miguel