日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

PD1-IL2v expands and induces effector CD8(+) TILs, but not Tregs, in the BCG treated orthotopic non-muscle invasive bladder cancer model

在 BCG 治疗的原位非肌层浸润性膀胱癌模型中，PD1-IL2v 可扩增并诱导效应 CD8(+) TILs，但不诱导 Tregs。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03667-w
Locatelli, Irene; Lorenzoni, Marco; Venegoni, Chiara; Di Coste, Alessia; Sorrentino, Rita; Jose, Jithin; Cirillo, Daniela Maria; Weber, Patrick; Manchala, Amrita; Hosse, Ralf J; Nicolini, Valeria; Umana, Pablo; Klein, Christian; Salonia, Andrea; Montorsi, Francesco; Bellone, Matteo; Moschini, Marco; Deak, Laura Codarri; Alfano, Massimo
肿瘤
IL2
T细胞
肿瘤免疫
CD8
Treg
膀胱癌
发表日期：2026
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4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models.

靶向成纤维细胞活化蛋白α的4-1BB激动剂与放射疗法协同治疗小鼠乳腺肿瘤模型

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2024-009852
Garate-Soraluze Eneko, Serrano-Mendioroz Irantzu, Fernández-Rubio Leticia, De Andrea Carlos E, Barrio-Alonso Celia, Herrero Claudia Del Pilar, Teijeira Alvaro, Luri-Rey Carlos, Claus Christina, Tanos Tamara, Klein Christian, Umana Pablo, Rullan Antonio, Simón Jon Ander, Collantes María, Sánchez-Mateos Paloma, Melero Ignacio, Rodriguez-Ruiz Maria E
肿瘤
发表日期：2025
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Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies.

黑色素瘤中的慢性抗原刺激会导致 T 细胞耗竭，并限制 T 细胞双特异性疗法的疗效

期刊:Oncoimmunology
影响因子:6.3
doi:10.1080/2162402X.2025.2526444
Hutter-Karakoc Idil, Varypataki Eleni Maria, Neelakandhan Aparna, Lang Simone, Kramar Vesna, Varol Ahmet, Simons Sasha, Richard Marine, Pincha Mudita, Venetz Dario, Sam Johannes, Joller Nicole, Münz Christian, Umana Pablo, Klein Christian, Amann Maria
细胞生物学
黑色素瘤
发表日期：2025
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Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade

铂类化疗会减弱CD8 T细胞对PD-1阻断的效应反应

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-23-1316
Mariniello, Annapaola; Nasti, Tahseen H; Chang, Daniel Y; Hashimoto, Masao; Malik, Sakshi; McManus, Daniel T; Lee, Judong; McGuire, Donald J; Cardenas, Maria A; Umana, Pablo; Nicolini, Valeria; Antia, Rustom; Saha, Ananya; Buchwald, Zachary; Kissick, Hayden; Ghorani, Ehsan; Novello, Silvia; Sangiolo, Dario; Scagliotti, Giorgio V; Ramalingam, Suresh S; Ahmed, Rafi
T细胞
CD8
T细胞
细胞生物学
PD-1
免疫/内分泌
发表日期：2024
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Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma

肿瘤激活的淋巴结成纤维细胞抑制弥漫性大B细胞淋巴瘤中的T细胞功能

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI166070
Apollonio, Benedetta; Spada, Filomena; Petrov, Nedyalko; Cozzetto, Domenico; Papazoglou, Despoina; Jarvis, Peter; Kannambath, Shichina; Terranova-Barberio, Manuela; Amini, Rose-Marie; Enblad, Gunilla; Graham, Charlotte; Benjamin, Reuben; Phillips, Elisabeth; Ellis, Richard; Nuamah, Rosamond; Saqi, Mansoor; Calado, Dinis P; Rosenquist, Richard; Sutton, Lesley A; Salisbury, Jon; Zacharioudakis, Georgios; Vardi, Anna; Hagner, Patrick R; Gandhi, Anita K; Bacac, Marina; Claus, Christina; Umana, Pablo; Jarrett, Ruth F; Klein, Christian; Deutsch, Alexander; Ramsay, Alan G
B细胞
成纤维细胞
肿瘤
T细胞
肿瘤免疫
淋巴瘤
T细胞
细胞生物学
免疫/内分泌
发表日期：2023
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GA101 P329GLALA, a variant of obinutuzumab with abolished ADCC, ADCP and CDC function but retained cell death induction, is as efficient as rituximab in B-cell depletion and antitumor activity

GA101 P329GLALA 是 obinutuzumab 的一种变体，其 ADCC、ADCP 和 CDC 功能被消除，但仍保留了诱导细胞死亡的能力，在 B 细胞清除和抗肿瘤活性方面与利妥昔单抗一样有效。

期刊:Haematologica
影响因子:7.9
doi:10.3324/haematol.2017.178996
Herter, Sylvia; Herting, Frank; Muth, Gunter; van Puijenbroek, Erwin; Schlothauer, Tilman; Ferrara, Claudia; Brady, Kevin; Lang, Sabine; Bacac, Marina; Mössner, Ekkehard; Umana, Pablo; Klein, Christian
DCC
肿瘤
T细胞
肿瘤免疫
细胞生物学
发表日期：2018
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CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors

CEA TCB：一种新型的头尾2:1 T细胞双特异性抗体，用于治疗CEA阳性实体瘤

期刊:Oncoimmunology
影响因子:6.3
doi:10.1080/2162402X.2016.1203498
Bacac, Marina; Klein, Christian; Umana, Pablo
细胞生物学
T细胞
T细胞
免疫/内分泌
发表日期：2016
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Enhanced anti-tumor activity of the glycoengineered type II CD20 antibody obinutuzumab (GA101) in combination with chemotherapy in xenograft models of human lymphoma

在人淋巴瘤异种移植模型中，糖基工程改造的 II 型 CD20 抗体 obinutuzumab (GA101) 与化疗联合应用可增强抗肿瘤活性。

期刊:Leukemia & Lymphoma
影响因子:2.2
doi:10.3109/10428194.2013.856008
Herting, Frank; Friess, Thomas; Bader, Sabine; Muth, Gunter; Hölzlwimmer, Gabriele; Rieder, Natascha; Umana, Pablo; Klein, Christian
CD20
肿瘤
CD2
淋巴瘤
肿瘤免疫
发表日期：2014
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Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing

具有受限结合功能的双特异性抗体衍生物，可通过蛋白水解加工激活

期刊:Protein Engineering Design & Selection
影响因子:3.4
doi:10.1093/protein/gzs064
Metz, Silke; Panke, Christian; Haas, Alexander K; Schanzer, Jürgen; Lau, Wilma; Croasdale, Rebecca; Hoffmann, Eike; Schneider, Britta; Auer, Johannes; Gassner, Christian; Bossenmaier, Birgit; Umana, Pablo; Sustmann, Claudio; Brinkmann, Ulrich
发表日期：2012
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Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains

开发具有抗病毒活性、对抗CCR5单克隆抗体耐药的HIV-1毒株的四价双特异性CCR5抗体

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00215-10
Schanzer, Jürgen; Jekle, Andreas; Nezu, Junichi; Lochner, Adriane; Croasdale, Rebecca; Dioszegi, Marianna; Zhang, Jun; Hoffmann, Eike; Dormeyer, Wilma; Stracke, Jan; Schäfer, Wolfgang; Ji, Changhua; Heilek, Gabrielle; Cammack, Nick; Brandt, Michael; Umana, Pablo; Brinkmann, Ulrich
HIV
单克隆抗体
CCR5
微生物学
发表日期：2011
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