In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen - 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima
利用计算机模拟鉴定、高产率分离和体外验证，从美丽云实（Caesalpinia pulcherrima）中分离得到6β-肉桂酰-7β-羟基vouacapen-5α-醇，该化合物是一种靶向Wnt/β-catenin通路的抗癌次生代谢产物。
期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0334238
Seneviratne, Nirwani N; Saliu, Tolulope P; Muhinudeen, Fathima T; Gamage, Sanadie D; Garusinghe, Prabudhi S; Chathuranga, Damith; Athukorala, Vinoda D; Kothalawala, Ashein; Jayasekara, Asirini H; Rathnayaka, Rajitha K; De Silva, Umanda Anjalee; Faries, Mohamed; Weragoda, Thimali H; Wijerathne, Shalini K; Rajagopalan, Umapriyatharshini; Senathilake, Kanishka S; Tennekoon, Kamani H; Adhikari, Achyut; Samarakoon, Sameera R
肿瘤
肿瘤免疫
信号转导
Wnt/β-Catenin
代谢
