Unadkat Jashvant D相关文献与解析，生知库

Elucidating the role of ABC transporters in the placental efflux of (-)- Δ(9)-tetrahydrocannabinol (THC) using a cocktail of ABC transport inhibitors

利用ABC转运抑制剂混合物阐明ABC转运蛋白在(-)-Δ(9)-四氢大麻酚(THC)胎盘外排中的作用

doi:10.1016/j.placenta.2025.12.012

Balhara, Ankit; Chen, Xin; Kumar, Aditya R; Wasickanin, Morgan E; Monson, Joshua W; Damicis, Jennifer R; Kinsman, Hillary J; Ieronimakis, Nicholas; Unadkat, Jashvant D

发表日期：2026

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Quantification and prediction of human fetal (-)-Δ(9)-tetrahydrocannabinol/(±)-11-OH-Δ(9)-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity

量化和预测人类胎儿在妊娠期间暴露于 (-)-Δ(9)-四氢大麻酚/(±)-11-OH-Δ(9)-四氢大麻酚的情况，以评估胎儿大麻毒性

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-55863-5

Kumar, Aditya R; Benson, Lyndsey S; Wymore, Erica M; Phipers, Jocelyn E; Dempsey, Jennifer C; Cort, Lucinda A; Unadkat, Jashvant D

毒理研究

发表日期：2025

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Rosuvastatin PBPK Modeling: Incorporating Liver Concentrations and Effects of Ethnicity, Genetic Polymorphisms, Lactone Formation, DDI and Pregnancy

瑞舒伐他汀生理药代动力学模型：纳入肝脏浓度以及种族、遗传多态性、内酯形成、药物相互作用和妊娠的影响

期刊:Cpt-Pharmacometrics & Systems Pharmacology

影响因子:3

doi:10.1002/psp4.70097

Balhara, Ankit; Weber, Robert H; Unadkat, Jashvant D

发表日期：2025

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Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms

促炎细胞因子对人近端肾小管上皮细胞肾脏转运蛋白的调控：致病因子的鉴定及机制

期刊:

影响因子:

doi:10.1101/2025.11.25.690608

Tsang, Yik Pui; Wang, Kai; Kelly, Edward J; Mao, Qingcheng; Unadkat, Jashvant D

Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells.

促炎细胞因子对原代人近端肾小管上皮细胞中人肾脏药物转运蛋白mRNA表达的失调作用

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics16020285

Tsang Yik Pui, Hao Tianran, Mao Qingcheng, Kelly Edward J, Unadkat Jashvant D

Are Δ(9)-Tetrahydrocannabinol and Its Major Metabolites Substrates or Inhibitors of Placental or Human Hepatic Drug Solute-Carrier Transporters?

Δ(9)-四氢大麻酚及其主要代谢物是胎盘或人肝脏药物溶质载体转运体的底物还是抑制剂？

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms252212036

Chen, Xin; Gáborik, Zsuzsanna; Mao, Qingcheng; Unadkat, Jashvant D

Human

发表日期：2024

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The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

妊娠相关激素对肝脏转运蛋白的影响：绝经前人类肝细胞的研究

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2024.1440010

Benzi, Jhohann Richard de Lima; Tsang, Yik Pui; Unadkat, Jashvant D

Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines

促炎细胞因子对人类肝脏药物转运蛋白的调控失常

期刊:Journal of Pharmacology and Experimental Therapeutics

影响因子:3.8

doi:10.1124/jpet.123.002019

Hao, Tianran; Tsang, Yik Pui; Yin, Mengyue; Mao, Qingcheng; Unadkat, Jashvant D

Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model

提高肝功能损害患者转运药物药代动力学预测的准确性：来自扩展清除模型的启示

期刊:Cpt-Pharmacometrics & Systems Pharmacology

影响因子:3

doi:10.1002/psp4.13062

Storelli, Flavia; Ladumor, Mayur K; Liang, Xiaomin; Lai, Yurong; Chothe, Paresh P; Enogieru, Osatohanmwen J; Evers, Raymond; Unadkat, Jashvant D

发表日期：2024

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Effect of proinflammatory cytokines on intestinal drug transporters in human enteroid monolayers

促炎细胞因子对人肠类器官单层细胞中肠道药物转运蛋白的影响

Elucidating the role of ABC transporters in the placental efflux of (-)- Δ(9)-tetrahydrocannabinol (THC) using a cocktail of ABC transport inhibitors

利用ABC转运抑制剂混合物阐明ABC转运蛋白在(-)-Δ(9)-四氢大麻酚(THC)胎盘外排中的作用

Quantification and prediction of human fetal (-)-Δ(9)-tetrahydrocannabinol/(±)-11-OH-Δ(9)-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity

量化和预测人类胎儿在妊娠期间暴露于 (-)-Δ(9)-四氢大麻酚/(±)-11-OH-Δ(9)-四氢大麻酚的情况，以评估胎儿大麻毒性

Rosuvastatin PBPK Modeling: Incorporating Liver Concentrations and Effects of Ethnicity, Genetic Polymorphisms, Lactone Formation, DDI and Pregnancy

瑞舒伐他汀生理药代动力学模型：纳入肝脏浓度以及种族、遗传多态性、内酯形成、药物相互作用和妊娠的影响

Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms

促炎细胞因子对人近端肾小管上皮细胞肾脏转运蛋白的调控：致病因子的鉴定及机制

Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells.

促炎细胞因子对原代人近端肾小管上皮细胞中人肾脏药物转运蛋白mRNA表达的失调作用

Are Δ(9)-Tetrahydrocannabinol and Its Major Metabolites Substrates or Inhibitors of Placental or Human Hepatic Drug Solute-Carrier Transporters?

Δ(9)-四氢大麻酚及其主要代谢物是胎盘或人肝脏药物溶质载体转运体的底物还是抑制剂？

The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

妊娠相关激素对肝脏转运蛋白的影响：绝经前人类肝细胞的研究

Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines

促炎细胞因子对人类肝脏药物转运蛋白的调控失常

Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model

提高肝功能损害患者转运药物药代动力学预测的准确性：来自扩展清除模型的启示