日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models

患者来源的单克隆LGI1自身抗体可在啮齿动物模型中诱发癫痫发作、行为改变和脑部MRI异常。

Upadhya, Manoj; Stumpf, Alexander; O'Brien-Cairney, Jack; Gómez, César Cordero; Döring, Jan; Hoffmann, Julius; Mueller, Susanne; Fukata, Yuko; van Hoof, Scott; Dhangar, Divya; Wilson, Max A; Atwal, Arunvir; Rosch, Richard; Woodhall, Gavin; Boehm-Sturm, Philipp; Fukata, Masaki; Kreye, Jakob; Schmitz, Dietmar; Wright, Sukhvir K; Kornau, Hans-Christian; Prüss, Harald

Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo

外周来源的LGI1反应性单克隆抗体可在体内引起癫痫发作。

Upadhya, Manoj; Kirmann, Toni; Wilson, Max A; Simon, Christian M; Dhangar, Divya; Geis, Christian; Williams, Robyn; Woodhall, Gavin; Hallermann, Stefan; Irani, Sarosh R; Wright, Sukhvir K

Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models.

人类脑脊液单克隆 CASPR2 自身抗体可引起啮齿动物模型的电生理、功能磁共振成像和行为改变

van Hoof Scott, Kreye Jakob, Cordero-Gómez César, Hoffmann Julius, Momsen Reincke S, Sánchez-Sendin Elisa, Duong Sophie L, Upadhya Manoj, Dhangar Divya, Michór Paulina, Woodhall Gavin L, Küpper Maraike, Oder Andreas, Kuchling Joseph, Koch Stefan Paul, Mueller Susanne, Boehm-Sturm Philipp, von Kries Jens Peter, Finke Carsten, Kirschstein Timo, Wright Sukhvir K, Prüss Harald

Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis

多模态电生理分析表明,在NMDAR抗体介导的脑炎模型中,突触兴奋性神经传递减少是癫痫发作的根本原因。

Wright, Sukhvir K; Rosch, Richard E; Wilson, Max A; Upadhya, Manoj A; Dhangar, Divya R; Clarke-Bland, Charlie; Wahid, Tamara T; Barman, Sumanta; Goebels, Norbert; Kreye, Jakob; Prüss, Harald; Jacobson, Leslie; Bassett, Danielle S; Vincent, Angela; Greenhill, Stuart D; Woodhall, Gavin L