日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

吗啡烷衍生的双重μ-κ阿片受体激动剂镇痛药的合成与药理学研究

Varga Balazs R, Uprety Rajendra, Paul Barnali, Knoll Alexis, Ramos-Gonzalez Nokomis, Appourchaux Kevin, Taylor Tori, Turgutalp Bengisu, Shinouchi Ryosuke, Eans Shainnel O, Williams Ashai K, Vasquez-Grinnell Steven G, Zaidi Saheem, Nazarova Antonina L, Varadi Andras, Le Rouzic Valerie, Brown Taylor G, Martinez Shani, Ansonoff Michael, Dardashti Rebecca Notis, Hunkele Amanda, Subrath Joan, Welch Matthew, Xu Jin, Rossi Grace C, Pintar John, Pasternak Gavril W, Katritch Vsevolod, McLaughlin Jay P, Pan Ying Xian, Majumdar Susruta

An anchor-tether 'hindered' HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model

一种锚定束缚“受阻”的HCN1抑制剂在保留神经损伤的大鼠神经病理性疼痛模型中具有抗痛觉过敏作用。

Tibbs, Gareth R; Uprety, Rajendra; Warren, J David; Beyer, Nicole P; Joyce, Rebecca L; Ferrer, Matthew A; Mellado, Wilfredo; Wong, Victor S C; Goldberg, David C; Cohen, Melanie W; Costa, Christopher J; Li, Zhucui; Zhang, Guoan; Dephoure, Noah E; Barman, Dipti N; Sun, Delin; Ingólfsson, Helgi I; Sauve, Anthony A; Willis, Dianna E; Goldstein, Peter A

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

7-羟基帽柱木碱是帽柱木碱的活性代谢产物,也是其镇痛作用的关键介质。

Kruegel, Andrew C; Uprety, Rajendra; Grinnell, Steven G; Langreck, Cory; Pekarskaya, Elizabeth A; Le Rouzic, Valerie; Ansonoff, Michael; Gassaway, Madalee M; Pintar, John E; Pasternak, Gavril W; Javitch, Jonathan A; Majumdar, Susruta; Sames, Dalibor

MP1104, a mixed kappa-delta opioid receptor agonist has anti-cocaine properties with reduced side-effects in rats

MP1104是一种混合型κ-δ阿片受体激动剂,具有抗可卡因特性,且在大鼠中副作用较小。

Atigari, Diana V; Uprety, Rajendra; Pasternak, Gavril W; Majumdar, Susruta; Kivell, Bronwyn M

Conditional control of alternative splicing through light-triggered splice-switching oligonucleotides

通过光触发剪接转换寡核苷酸对选择性剪接进行条件性控制

Hemphill, James; Liu, Qingyang; Uprety, Rajendra; Samanta, Subhas; Tsang, Michael; Juliano, Rudolph L; Deiters, Alexander

Site-specific promoter caging enables optochemical gene activation in cells and animals

位点特异性启动子笼蔽技术可实现细胞和动物体内的光化学基因激活。

Hemphill, James; Govan, Jeane; Uprety, Rajendra; Tsang, Michael; Deiters, Alexander

Genetically encoded optochemical probes for simultaneous fluorescence reporting and light activation of protein function with two-photon excitation.

利用双光子激发,通过基因编码的光化学探针,可以同时进行荧光报告和光激活蛋白质功能

Luo Ji, Uprety Rajendra, Naro Yuta, Chou Chungjung, Nguyen Duy P, Chin Jason W, Deiters Alexander

Control of protein function through optochemical translocation

通过光化学转位控制蛋白质功能

Engelke, Hanna; Chou, Chungjung; Uprety, Rajendra; Jess, Phillip; Deiters, Alexander

Cellular delivery and photochemical activation of antisense agents through a nucleobase caging strategy

通过核碱基笼蔽策略实现反义剂的细胞递送和光化学活化

Govan, Jeane M; Uprety, Rajendra; Thomas, Meryl; Lusic, Hrvoje; Lively, Mark O; Deiters, Alexander

Regulation of transcription through light-activation and light-deactivation of triplex-forming oligonucleotides in mammalian cells

哺乳动物细胞中通过光激活和光失活三链形成寡核苷酸来调控转录

Govan, Jeane M; Uprety, Rajendra; Hemphill, James; Lively, Mark O; Deiters, Alexander