日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A stochastic simulation-based approach to inform the relapsing mouse model study design for non-clinical assessment of tuberculosis

一种基于随机模拟的方法,用于指导复发性小鼠模型研究设计,以进行结核病的非临床评估

Clary, James; Roberts, Jessica K; Hanna, Debra; Tagliavini, Alessia; Sordello, Sylvie; Upton, Anna; Hermann, David; Berg, Alexander

A modeling-based framework to evaluate forgiveness of tuberculosis treatment in a BALB/c relapsing mouse model

基于模型的框架用于评估BALB/c复发性小鼠结核病治疗的耐受性

Sordello, Sylvie; Brock, Laure; Tagliavini, Alessia; Federico, Denise; Boulenc, Xavier; Pergher, Marco; Huc Claustre, Emilie; Metcalf, Darren; Walter, Nicholas D; Robertson, Gregory T; Clary, James; Berg, Alexander; Mdluli, Khisi; Hermann, David; Flood, Debra; Upton, Anna M

The role of cytochrome bc(1) inhibitors in future tuberculosis treatment regimens

细胞色素bc(1)抑制剂在未来结核病治疗方案中的作用

Aguilar-Pérez, Clara; Lenaerts, Anne J; Villellas, Cristina; Guillemont, Jerome; Dallow, John; Painter, Hannah; Ammerman, Nicole C; Hassan, Anis; Golovkine, Guillaume; Brock, Laure; Sordello, Sylvie; Chauffour, Aurélie; Aubry, Alexandra; Mai, Thi Cuc; Wong, Sarah; Clark, Taane G; Nam, Kiyean; Kim, Jeongjun; Choi, Jinho; Crabbe, Marjolein; Esquivias, Jorge; Lounis, Nacer; Stoops, Bart; Amssoms, Katie; Bartolome-Nebreda, Jose M; Gruppo, Veronica; Robertson, Gregory T; Veziris, Nicolas; Upton, Anna M; Nuermberger, Eric L; Cox, Vivian; Ballell, Lluis; Baeten, Benny; Koul, Anil; Pym, Alexander S; Wall, Richard J; Lamprecht, Dirk A

Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.

将 raltitrexed 从癌细胞胸苷酸合成酶重定向到结核分枝杆菌磷酸泛酰巯基转移酶

Singh Amrita, Ottavi Samantha, Krieger Inna, Planck Kyle, Perkowski Andrew, Kaneko Takushi, Davis Andrew M, Suh Christine, Zhang David, Goullieux Laurent, Alex Alexander, Roubert Christine, Gardner Mark, Preston Marian, Smith Dave M, Ling Yan, Roberts Julia, Cautain Bastien, Upton Anna, Cooper Christopher B, Serbina Natalya, Tanvir Zaid, Mosior John, Ouerfelli Ouathek, Yang Guangli, Gold Ben S, Rhee Kyu Y, Sacchettini James C, Fotouhi Nader, Aubé Jeffrey, Nathan Carl

Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis

在结核病小鼠模型中,贝达喹啉或TBAJ-587与GSK2556286和TBA-7371联合使用的新方案的杀菌和灭菌活性

Li, Si-Yang; Tyagi, Sandeep; Soni, Heena; Betoudji, Fabrice; Converse, Paul J; Mdluli, Khisimuzi; Upton, Anna M; Fotouhi, Nader; Barros-Aguirre, David; Ballell, Lluís; Jimenez-Navarro, Elena; Nuermberger, Eric L

Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model

在小鼠结核病模型中,新一代二芳基喹啉类化合物可提高普瑞托马尼和新型噁唑烷酮类药物TBI-223联合治疗方案的杀菌活性。

Li, Si-Yang; Converse, Paul J; Betoudji, Fabrice; Lee, Jin; Mdluli, Khisimuzi; Upton, Anna; Fotouhi, Nader; Nuermberger, Eric L

Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis

鉴定细胞色素bd的2-芳基喹诺酮抑制剂及抗结核分枝杆菌呼吸抑制剂组合策略的化学验证

Jeffreys, Laura N; Ardrey, Alison; Hafiz, Taghreed A; Dyer, Lauri-Anne; Warman, Ashley J; Mosallam, Nada; Nixon, Gemma L; Fisher, Nicholas E; Hong, W David; Leung, Suet C; Aljayyoussi, Ghaith; Bibby, Jaclyn; Almeida, Deepak V; Converse, Paul J; Fotouhi, Nader; Berry, Neil G; Nuermberger, Eric L; Upton, Anna M; O'Neill, Paul M; Ward, Stephen A; Biagini, Giancarlo A

"Upcycling" known molecules and targets for drug-resistant TB

利用已知分子和靶点“升级改造”耐药结核病

Roubert, Christine; Fontaine, Evelyne; Upton, Anna M

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.

GSK2556286 是一种新型抗结核药物候选物,在体内有效,有可能缩短结核病疗程

Nuermberger Eric L, Martínez-Martínez Maria Santos, Sanz Olalla, Urones Beatriz, Esquivias Jorge, Soni Heena, Tasneen Rokeya, Tyagi Sandeep, Li Si-Yang, Converse Paul J, Boshoff Helena I, Robertson Gregory T, Besra Gurdyal S, Abrahams Katherine A, Upton Anna M, Mdluli Khisimuzi, Boyle Gary W, Turner Sam, Fotouhi Nader, Cammack Nicholas C, Siles Juan Miguel, Alonso Marta, Escribano Jaime, Lelievre Joel, Rullas-Trincado Joaquin, Pérez-Herrán Esther, Bates Robert H, Maher-Edwards Gareth, Barros David, Ballell Lluís, Jiménez Elena

The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection

新型噁唑烷酮类药物TBI-223在三种耐甲氧西林金黄色葡萄球菌感染的临床前小鼠模型中均显示出疗效。

Gordon, Oren; Dikeman, Dustin A; Ortines, Roger V; Wang, Yu; Youn, Christine; Mumtaz, Mohammed; Orlando, Nicholas; Zhang, Jeffrey; Patel, Aman M; Gough, Ethan; Kaushik, Amit; Nuermberger, Eric L; Upton, Anna M; Fotouhi, Nader; Miller, Lloyd S; Archer, Nathan K