日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A dual sensor regulates P-glycoprotein's structural plasticity

双传感器调节P-糖蛋白的结构可塑性

Kamel, Michael; Schäfer, Jan-Hannes; Jaramillo-Martinez, Valeria; Tran, Nghi N B; Mangold, Devin L; Shvarev, Dmitry; Schnelle, Kilian; Parey, Kristian; Januliene, Dovile; Urbatsch, Ina L; Moeller, Arne

Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein

脂质环境决定了P-糖蛋白的药物刺激ATPase活性。

Tran, Nghi N B; Bui, A T A; Jaramillo-Martinez, Valeria; Weber, Joachim; Zhang, Qinghai; Urbatsch, Ina L

Peptide Tags and Domains for Expression and Detection of Mammalian Membrane Proteins at the Cell Surface

用于在细胞表面表达和检测哺乳动物膜蛋白的肽标签和结构域

Jaramillo-Martinez, Valeria; Ganapathy, Vadivel; Urbatsch, Ina L

A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects

人类NaCT/SLC13A5/INDY研究取得重大突破:冷冻电镜结构和同源模型可用于预测转运机制、抑制剂相互作用和突变缺陷

Jaramillo-Martinez, Valeria; Ganapathy, Vadivel; Urbatsch, Ina L

Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)

对人钠离子偶联柠檬酸转运蛋白(NaCT/SLC13A5/mINDY)选择性物种特异性抑制剂的功能分析

Higuchi, Kei; Kopel, Jonathan J; Sivaprakasam, Sathish; Jaramillo-Martinez, Valeria; Sutton, R Bryan; Urbatsch, Ina L; Ganapathy, Vadivel

Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.

通过核苷酸结合域 1 的突变,可以系统地提高纯化的人类 CFTR 的结构稳定性

Yang Zhengrong, Hildebrandt Ellen, Jiang Fan, Aleksandrov Andrei A, Khazanov Netaly, Zhou Qingxian, An Jianli, Mezzell Andrew T, Xavier Bala M, Ding Haitao, Riordan John R, Senderowitz Hanoch, Kappes John C, Brouillette Christie G, Urbatsch Ina L

Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.

ATP水解过程中脂质双层相关P-糖蛋白核苷酸结合域的底物诱导构象变化

Zoghbi Maria E, Mok Leo, Swartz Douglas J, Singh Anukriti, Fendley Gregory A, Urbatsch Ina L, Altenberg Guillermo A

A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface

一种稳定的人类细胞系统,可在细胞表面过表达囊性纤维化跨膜传导调节因子重组蛋白

Hildebrandt, Ellen; Mulky, Alok; Ding, Haitao; Dai, Qun; Aleksandrov, Andrei A; Bajrami, Bekim; Diego, Pamela Ann; Wu, Xing; Ray, Marjorie; Naren, Anjaparavanda P; Riordan, John R; Yao, Xudong; DeLucas, Lawrence J; Urbatsch, Ina L; Kappes, John C

Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains

膜蛋白的稳定性会因去垢剂与膜外可溶性结构域的相互作用而受损。

Yang, Zhengrong; Wang, Chi; Zhou, Qingxian; An, Jianli; Hildebrandt, Ellen; Aleksandrov, Luba A; Kappes, John C; DeLucas, Lawrence J; Riordan, John R; Urbatsch, Ina L; Hunt, John F; Brouillette, Christie G

A survey of detergents for the purification of stable, active human cystic fibrosis transmembrane conductance regulator (CFTR).

对用于纯化稳定、活性人类囊性纤维化跨膜传导调节因子 (CFTR) 的洗涤剂进行调查

Hildebrandt Ellen, Zhang Qinghai, Cant Natasha, Ding Haitao, Dai Qun, Peng Lingling, Fu Yu, DeLucas Lawrence J, Ford Robert, Kappes John C, Urbatsch Ina L