日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

STING 激动剂可克服卵巢癌中 STAT3 介导的免疫抑制和对 PARP 抑制的适应性抵抗

Liya Ding, Qiwei Wang #, Antons Martincuks #, Michael J Kearns, Tao Jiang, Ziying Lin, Xin Cheng, Changli Qian, Shaozhen Xie, Hye-Jung Kim, Inga-Maria Launonen, Anniina Färkkilä, Thomas M Roberts, Gordon J Freeman, Joyce F Liu, Panagiotis A Konstantinopoulos, Ursula Matulonis, Hua Yu, Jean J Zhao0

A single-cell landscape of high-grade serous ovarian cancer

高级别浆液性卵巢癌的单细胞图谱

Benjamin Izar # ,Itay Tirosh # ,Elizabeth H Stover # ,Isaac Wakiro ,Michael S Cuoco ,Idan Alter ,Christopher Rodman ,Rachel Leeson ,Mei-Ju Su ,Parin Shah ,Marcin Iwanicki ,Sarah R Walker ,Abhay Kanodia ,Johannes C Melms ,Shaolin Mei ,Jia-Ren Lin ,Caroline B M Porter ,Michal Slyper ,Julia Waldman ,Livnat Jerby-Arnon ,Orr Ashenberg ,Titus J Brinker ,Caitlin Mills ,Meri Rogava ,Sébastien Vigneau ,Peter K Sorger ,Levi A Garraway ,Panagiotis A Konstantinopoulos ,Joyce F Liu ,Ursula Matulonis ,Bruce E Johnson ,Orit Rozenblatt-Rosen ,Asaf Rotem ,Aviv Regev

Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course

与 BRCA 野生型卵巢癌患者相比,在早期疾病过程中,BRCA 突变卵巢癌患者的循环 MDSC 可能较少,而外周 CD8+ T 细胞可能较多

Jung-Min Lee, Dana-Adriana Botesteanu, Yusuke Tomita, Akira Yuno, Min-Jung Lee, Elise C Kohn, Christina M Annunziata, Ursula Matulonis, Lauren A MacDonald, Jayakumar R Nair, Kimberley M Macneill, Jane B Trepel

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas

MicroRNA 493-5p 对基因组稳定途径的多方面影响诱导 BRCA2 突变癌症产生铂和 PARP 抑制剂耐药性

Khyati Meghani, Walker Fuchs, Alexandre Detappe, Pascal Drané, Ewa Gogola, Sven Rottenberg, Jos Jonkers, Ursula Matulonis, Elizabeth M Swisher, Panagiotis A Konstantinopoulos, Dipanjan Chowdhury

Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

高效毒素的纳米颗粒结合物可增强安全性并避免卵巢癌的铂耐药性

Ruogu Qi, Yongheng Wang, Peter M Bruno, Haihua Xiao, Yingjie Yu, Ting Li, Sam Lauffer, Wei Wei, Qixian Chen, Xiang Kang, Haiqin Song, Xi Yang, Xing Huang, Alexandre Detappe, Ursula Matulonis, David Pepin, Michael T Hemann, Michael J Birrer, P Peter Ghoroghchian

Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer

BRCA1 突变卵巢癌中 MicroRNA-622 过度表达导致铂和 PARP 抑制剂耐药

Young Eun Choi, Khyati Meghani, Marie-Eve Brault, Lucas Leclerc, Yizhou J He, Tovah A Day, Kevin M Elias, Ronny Drapkin, David M Weinstock, Fanny Dao, Karin K Shih, Ursula Matulonis, Douglas A Levine, Panagiotis A Konstantinopoulos, Dipanjan Chowdhury

The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancer

PARP1 抑制剂 BMN 673 在 Brca1(-/-) 小鼠卵巢癌模型中表现出免疫调节作用

Jing Huang, Lei Wang, Zhongyi Cong, Zohreh Amoozgar, Evgeny Kiner, Deyin Xing, Sandra Orsulic, Ursula Matulonis, Michael S Goldberg

Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model

抗 CCR4 单克隆抗体通过调节卵巢癌异种移植人源化小鼠模型中的肿瘤浸润 Treg 增强抗肿瘤免疫力

De-Kuan Chang, Eric Peterson, Jiusong Sun, Calum Goudie, Ronny I Drapkin, Joyce F Liu, Ursula Matulonis, Quan Zhu, Wayne A Marasco

Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance

表达间充质基因程序的卵巢癌球体表现出增强的间皮清除率

Rachel A Davidowitz, Laura M Selfors, Marcin P Iwanicki, Kevin M Elias, Alison Karst, Huiying Piao, Tan A Ince, Michael G Drage, Judy Dering, Gottfried E Konecny, Ursula Matulonis, Gordon B Mills, Dennis J Slamon, Ronny Drapkin, Joan S Brugge

Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival

卵巢癌中 elafin 的过度表达是由基因组增益和核因子 κB 通路的激活所驱动的,并且与总体生存率较低有关

Adam Clauss, Vivian Ng, Joyce Liu, Huiying Piao, Moises Russo, Natalie Vena, Qing Sheng, Michelle S Hirsch, Tomas Bonome, Ursula Matulonis, Azra H Ligon, Michael J Birrer, Ronny Drapkin