日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus.

选择性抑制 Na v 1.8 对恒河猴镇痛和外周 C 纤维调节的影响

Vardigan Joshua D, Pall Parul S, McDevitt Dillon S, Huang ChienJung, Clements Michelle K, Li Yuxing, Kraus Richard L, Breslin Michael J, Bungard Christopher J, Nemenov Mikhail I, Klukinov Mikhail, Burgey Chritopher S, Layton Mark E, Stachel Shawn J, Lange Henry S, Savitz Alan T, Santarelli Vincent P, Henze Darrell A, Uslaner Jason M

Preclinical development of MK‐2214 a novel antibody targeting pS413 tau for the treatment of Alzheimer’s Disease

MK-2214是一种靶向pS413 tau的新型抗体,目前正处于治疗阿尔茨海默病的临床前开发阶段。

Elmore, Susan A; Berridge, Brian R; Boyle, Michael C; Cora, Michelle C; Hoenerhoff, Mark J; Kooistra, Linda; Laast, Victoria A; Morrison, James P; Rao, Deepa; Rinke, Matthias; Yoshizawa, Katsuhiko; Sugam, Jonathan A; Robey, Seth; Suon, Sokreine; Tian, Yuan; Wong, Oitak; Zhao, Xuemei; Chen, Ying; Judo, Michael; Smith, Brad E; Popescu, Andrei; Kurz, Jonathan; Herring, W Joseph; Baker, Jeanne; Parmentier‐Batteur, Sophie; Klein, Rebecca M; Smith, Sean M; Uslaner, Jason M

2-Aminopyridines as Potent and Selective Na(v)1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model

2-氨基吡啶类化合物作为强效且选择性的Na(v)1.8抑制剂,在非人灵长类动物疼痛模型中显示出疗效。

Breslin, Michael J; Schubert, Jeffrey W; Wang, Deping; Huang, Chienjung; Clements, Michelle K; Li, Yuxing; Zhou, Xiaoping; Vardigan, Joshua D; Kraus, Richard L; Santarelli, Vincent P; Uslaner, Jason M; Coleman, Paul J; Stachel, Shawn J

Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets

解析 iPSC 衍生神经元中 Ataxin-2 和 TDP-43 的相互作用组,寻找潜在的 ALS 靶点

Yuan Tian, Nicolette Heinsinger, Yinghui Hu, U-Ming Lim, Yi Wang, Aaron Zefrin Fernandis, Sophie Parmentier-Batteur, Becky Klein, Jason M Uslaner, Sean M Smith

Data‐driven progression patterns of Aβ, tau, α‐synuclein and vascular pathology in a clinical population

临床人群中Aβ、tau、α-突触核蛋白和血管病理的数据驱动进展模式

Gamache, Dominick; Savard, Claudia; Leclerc, Philippe; Payant, Maude; Côté, Alexandre; Faucher, Jonathan; Lampron, Mireille; Tremblay, Marc; Yuchuan, Wang; Mitchell, Helen J; Lee, Susi; Zeng, Zhizhen; Miller, Patricia J; Bennacef, Idriss; Riffel, Kerry; Purcell, Mona L; Haley, Hyking D; Gantert, Liza T; Marie, Holahan A; Meng, Xiangjun; Stenslik, Mallory; Ma, Lei M; Fay, John F; Li, Wenping; Marcus, Jacob; Smith, Sean M; Uslaner, Jason M; Drolet, Robert E; Hostetler, Eric D; Mastenbroek, Sophie E; Collij, Lyduine E; Vogel, Jacob W; Young, Alexandra L; Strandberg, Olof; Smith, Ruben; Palmqvist, Sebastian; Mattsson‐Carlgren, Niklas; Barkhof, Frederik; Ossenkoppele, Rik; Hansson, Oskar

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

发现用于治疗精神分裂症的高效选择性 PDE10A 抑制剂 MK-8189

Mark E Layton, Jeffrey C Kern, Timothy J Hartingh, William D Shipe, Izzat Raheem, Monika Kandebo, Robert P Hayes, Sarah Huszar, Donnie Eddins, Bennett Ma, Joy Fuerst, Gordon K Wollenberg, Jing Li, Jeff Fritzen, Georgia B McGaughey, Jason M Uslaner, Sean M Smith, Paul J Coleman, Christopher D Cox

Discovery of [(11)C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR(2) Negative Allosteric Modulators

[(11)C]MK-8056 的发现:一种用于研究 mGluR(2) 负变构调节剂的选择性 PET 成像剂

Perkins, James J; McQuade, Paul; Bungard, Christopher J; Diamond, Tracy L; Gantert, Liza T; Gotter, Anthony L; Hanney, Barbara; Hills, Ivory D; Hurzy, Danielle M; Joshi, Aniket; Kern, Jonathan T; Schlegel, Kelly-Ann S; Manikowski, Jesse J; Meng, Zhaoyang; O'Brien, Julie A; Roecker, Anthony J; Smith, Sean M; Uslaner, Jason M; Hostetler, Eric; Meissner, Robert S

Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator

发现MK-8768,一种强效且选择性的mGluR2负变构调节剂

Rudd, Michael T; Manley, Peter J; Hanney, Barbara; Meng, Zhaoyang; Shu, Youheng; de Leon, Pablo; Frie, Jessica L; Han, Yongxin; Wai, Jenny Miu-Chun; Yang, Zhi-Qiang; Perkins, James J; Hurzy, Danielle M; Manikowski, Jesse J; Zhu, Hong; Bungard, Christopher J; Converso, Antonella; Meissner, Robert S; Cosden, Mali L; Hayashi, Ikuo; Ma, Lei; O'Brien, Julie; Uebele, Victor N; Schachter, Joel B; Bhandari, Neetesh; Ward, Gwendolyn J; Fillgrove, Kerry L; Lu, Bing; Liang, Yuexia; Dubost, David C; Puri, Vanita; Eddins, Donnie M; Vardigan, Joshua D; Drolet, Robert E; Kern, Jonathan T; Uslaner, Jason M

scRNA-seq generates a molecular map of emerging cell subtypes after sciatic nerve injury in rats

单细胞RNA测序技术生成了大鼠坐骨神经损伤后新出现的细胞亚型的分子图谱

Lovatt, Ditte; Tamburino, Alex; Krasowska-Zoladek, Alicja; Sanoja, Raul; Li, Lixia; Peterson, Vanessa; Wang, Xiaohai; Uslaner, Jason

A Novel Biomarker of Neuronal Glutamate Metabolism in Nonhuman Primates Using Localized (1)H-Magnetic Resonance Spectroscopy: Development and Effects of BNC375, an α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator

利用局部(1)H-磁共振波谱法在非人灵长类动物中发现一种新型神经元谷氨酸代谢生物标志物:α7尼古丁乙酰胆碱受体正向变构调节剂BNC375的开发和作用

Miller, Corin O; Gantert, Liza T; Previs, Stephen F; Chen, Ying; Anderson, Kenneth D; Thomas, Justina M; Sanacora, Gerard; Uslaner, Jason M; Rothman, Douglas L; Mason, Graeme F