日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

基孔肯雅病毒nsP2解旋酶-蛋白酶的结构域间灵活性对病毒RNA复制和感染性具有差异性影响。

Law, Yee-Song; Wang, Sainan; Tan, Yaw Bia; Shih, Orion; Utt, Age; Goh, Wei Yang; Lian, Bing-Jun; Chen, Ming Wei; Jeng, U-Ser; Merits, Andres; Luo, Dahai

Sensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein Processing

甲病毒对G3BP缺失的敏感性与复制酶多聚蛋白加工效率相关

Götte, Benjamin; Utt, Age; Fragkoudis, Rennos; Merits, Andres; McInerney, Gerald M

Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis

硼替佐米通过干扰病毒蛋白合成来抑制基孔肯雅病毒复制。

Kaur, Parveen; Lello, Laura Sandra; Utt, Age; Dutta, Sujit Krishna; Merits, Andres; Chu, Justin Jang Hann

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

基孔肯雅病毒nsP2解旋酶识别RNA的结构解析

Law, Yee-Song; Utt, Age; Tan, Yaw Bia; Zheng, Jie; Wang, Sainan; Chen, Ming Wei; Griffin, Patrick R; Merits, Andres; Luo, Dahai

Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

利用哺乳动物和蚊子RNA聚合酶I介导的转录设计和使用基孔肯雅病毒复制模板

Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

罗斯河病毒毒力降低是由于其非结构多聚蛋白第一切割位点发生突变,导致干扰素诱导RNA的产生增加。

Liu, Xiang; Mutso, Margit; Utt, Age; Lepland, Anni; Herrero, Lara J; Taylor, Adam; Bettadapura, Jayaram; Rudd, Penny A; Merits, Andres; Mahalingam, Suresh

A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells

基孔肯雅病毒反式复制酶系统揭示了延迟的非结构多聚蛋白加工对于蚊细胞中高效复制复合物形成的重要性

Bartholomeeusen, Koen; Utt, Age; Coppens, Sandra; Rausalu, Kai; Vereecken, Katleen; Ariën, Kevin K; Merits, Andres

Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

部分未切割的甲病毒复制酶在有无RNA模板的情况下均能形成球状结构

Hellström, Kirsi; Kallio, Katri; Utt, Age; Quirin, Tania; Jokitalo, Eija; Merits, Andres; Ahola, Tero

Design and Validation of Novel Chikungunya Virus Protease Inhibitors

新型基孔肯雅病毒蛋白酶抑制剂的设计与验证

Das, Pratyush Kumar; Puusepp, Laura; Varghese, Finny S; Utt, Age; Ahola, Tero; Kananovich, Dzmitry G; Lopp, Margus; Merits, Andres; Karelson, Mati

Correction for Thaa et al., Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

对 Thaa 等人的研究更正:塞姆利基森林病毒和基孔肯雅病毒对磷脂酰肌醇-3-激酶-Akt-mTOR 通路的差异性激活依赖于 nsP3,并与复制复合物内化有关。

Thaa, Bastian; Biasiotto, Roberta; Eng, Kai; Neuvonen, Maarit; Götte, Benjamin; Rheinemann, Lara; Mutso, Margit; Utt, Age; Varghese, Finny; Balistreri, Giuseppe; Merits, Andres; Ahola, Tero; M McInerney, Gerald