Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression
EGFR、MEK 和 PD-L1 的三重阻断在具有 MAPK 信号传导组成性激活和 PD-L1 过表达的结直肠癌模型中具有抗肿瘤活性
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-019-1497-0
S Napolitano, N Matrone, A L Muddassir, G Martini, A Sorokin, V De Falco, E F Giunta, D Ciardiello, E Martinelli, V Belli, M Furia, S Kopetz, F Morgillo, F Ciardiello, T Troiani