日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes

儿童发展为 1 型糖尿病过程中免疫细胞单核分辨率的表观基因组演变

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69923-x
Pastinen, Tomi; Grundberg, Elin; Bradley, Todd; Honkanen, Jarno; Cheung, Warren A; Vuorela, Arja; Johnston, Jeffrey J; Yoo, Byunggil; Khanal, Santosh; McLennan, Rebecca; Ilonen, Jorma; Vaarala, Outi; Krischer, Jeffrey P; Knip, Mikael
表观遗传
代谢
糖尿病
细胞生物学
免疫/内分泌
发表日期：2026
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Single-cell RNA-seq analysis of longitudinal CD4(+) T cell samples reveals cell-type-specific changes during early stages of type 1 diabetes

对纵向 CD4(+) T 细胞样本进行单细胞 RNA 测序分析，揭示了 1 型糖尿病早期阶段细胞类型特异性变化

期刊:Genome Medicine
影响因子:11.2
doi:10.1186/s13073-025-01574-x
Biradar, Rahul; Kalim, Ubaid Ullah; Lönnberg, Tapio; Junttila, Sini; Suomi, Tomi; Norman, Sebastián Zúñiga; Starskaia, Inna; Paulin, Niklas; Mikkola, Lea; Vaarala, Outi; Rasool, Omid; Knip, Mikael; Elo, Laura L; Lahesmaa, Riitta
T细胞
代谢
糖尿病
细胞生物学
CD4
单细胞
发表日期：2025
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High Concentrations of Immunoglobulin G Against Cow Milk Proteins and Frequency of Cow Milk Consumption Are Associated With the Development of Islet Autoimmunity and Type 1 Diabetes-The Trial to Reduce Insulin-dependent Diabetes Mellitus (IDDM) in the Genetically at Risk (TRIGR) Study

高浓度的抗牛奶蛋白免疫球蛋白G和牛奶摄入频率与胰岛自身免疫和1型糖尿病的发生相关——降低遗传风险人群胰岛素依赖型糖尿病（IDDM）的试验（TRIGR）研究

期刊:Journal of Nutrition
影响因子:3.8
doi:10.1016/j.tjnut.2024.06.005
Niinistö, Sari; Cuthbertson, David; Miettinen, Maija E; Hakola, Leena; Nucci, Anita; Korhonen, Tuuli E; Hyöty, Heikki; Krischer, Jeffrey P; Vaarala, Outi; Knip, Mikael; Savilahti, Erkki; Virtanen, Suvi M
代谢
糖尿病
免疫/内分泌
发表日期：2024
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Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer Progression

TEAD1/ITGA1/ITGA2 调节电路减弱可促进 TGFβ1 信号传导，从而调控前列腺癌进展

期刊:Advanced Science
影响因子:
doi:10.1002/advs.202305547
Sara P Cruz, Qin Zhang, Raman Devarajan, Christos Paia, Binjie Luo, Kai Zhang, Saara Koivusalo, Longguang Qin, Jihan Xia, Anne Ahtikoski, Markku Vaarala, Tomasz Wenta, Gong-Hong Wei, Aki Manninen
信号转导
肿瘤
前列腺癌
TGF-β
发表日期：2024
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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD

多组学研究揭示了慢性阻塞性肺疾病中全身表面活性剂失调与气流阻塞和肺气肿之间的关联

期刊:Erj Open Research
影响因子:4
doi:10.1183/23120541.00378-2022
Hristova, Ventzislava A; Watson, Alastair; Chaerkady, Raghothama; Glover, Matthew S; Ackland, Jodie; Angerman, Bastian; Belfield, Graham; Belvisi, Maria G; Burke, Hannah; Cellura, Doriana; Clark, Howard W; Etal, Damla; Freeman, Anna; Heinson, Ashley I; Hess, Sonja; Hühn, Michael; Hall, Emily; Mackay, Alex; Madsen, Jens; McCrae, Christopher; Muthas, Daniel; Novick, Steven; Ostridge, Kristoffer; Öberg, Lisa; Platt, Adam; Postle, Anthony D; Spalluto, C Mirella; Vaarala, Outi; Wang, Junmin; Staples, Karl J; Wilkinson, Tom M A
慢性阻塞性肺疾病
发表日期：2023
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Breastfeeding and circulating immunological markers during the first 3 years of life: the DIABIMMUNE study

母乳喂养和生命前 3 年内的循环免疫标志物：DIABIMMUNE 研究

期刊:Diabetologia
影响因子:8.4
doi:10.1007/s00125-021-05612-2
Maija E Miettinen, Jarno Honkanen, Sari Niinistö, Outi Vaarala, Suvi M Virtanen, Mikael Knip; DIABIMMUNE Study Group
免疫
发表日期：2022
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Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions

α6β4 介导的半桥粒粘连的分解通过将网蛋白靶向粘着斑来促进 PTEN 阴性前列腺癌的肿瘤发生

期刊:Oncogene
影响因子:6.9
doi:10.1038/s41388-022-02389-5
Tomasz Wenta, Anette Schmidt, Qin Zhang, Raman Devarajan, Prateek Singh, Xiayun Yang, Anne Ahtikoski, Markku Vaarala, Gong-Hong Wei, Aki Manninen
信号转导
肿瘤
前列腺癌
Adhesion/ECM
发表日期：2022
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Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study

患胰岛自身免疫的儿童血清脂肪酸与免疫标志物之间的关联 - TRIGR 嵌套病例对照研究

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2022.858875
Sari Niinistö, Maija E Miettinen, David Cuthbertson, Jarno Honkanen, Leena Hakola, Reija Autio, Iris Erlund, Petra Arohonka, Arja Vuorela, Taina Härkönen, Heikki Hyöty, Jeffrey P Krischer, Outi Vaarala, Mikael Knip, Suvi M Virtanen; TRIGR Investigators
免疫
发表日期：2022
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A rare and complete response to combination therapy with radiation and nivolumab in a patient with metastatic urothelial cancer

一例转移性尿路上皮癌患者对放疗联合纳武利尤单抗治疗获得罕见的完全缓解

期刊:BMJ Case Reports
影响因子:0.5
doi:10.1136/bcr-2021-246653
Hietala, Aki; Joutsen, Jenny; Vaarala, Svea; Säily, Matti
肿瘤
肿瘤免疫
发表日期：2022
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Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

在 Pandemrix 相关 1 型发作性睡病中，甲型流感 H1N1 T 细胞表位识别增强，且与蛋白质-O-甘露糖基转移酶 1 有交叉反应

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-021-22637-8
A Vuorela #, T L Freitag #, K Leskinen, H Pessa, T Härkönen, I Stracenski, T Kirjavainen, P Olsen, O Saarenpää-Heikkilä, J Ilonen, M Knip, A Vaheri, M Partinen, P Saavalainen, S Meri, O Vaarala
免疫
细胞生物学
流感
T细胞
发表日期：2021
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