Variation at the R181 residue of p53 confers loss of p53 DNA binding cooperativity with the retention of mitochondrial-associated apoptosis.
p53 R181 残基的变异导致 p53 DNA 结合协同作用丧失,但线粒体相关细胞凋亡仍得以保留
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doi:10.1101/2025.08.12.669925
Moses Renyta, Indeglia Alexandra, Levine Alison S, Hausler Ryan, Kelly Gregory, Miller Sven A, Anez Isabel, Heller Melissa, Delgado Rosella, Orr Caitlin, Kohlmann Wendy, Naumer Anne, Vagher Jennie, Cahill Sophie R, Maese Luke D, Karanicolas John, Garber Judy E, Murphy Maureen E, Maxwell Kara N