Enhanced anti-tumor activity by zinc finger repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs
锌指抑制因子驱动的免疫检查点和TGFBR2在CAR-T细胞和TILs中的表观遗传沉默增强了抗肿瘤活性
期刊:Molecular Therapy Oncology
影响因子:5.3
doi:10.1016/j.omton.2025.200989
David, Marion; Schiele, Phillip; Monteferrario, Davide; Saviane, Gaëlle; Martelli, Angélique E; Dupont, Coralie F; Jeanneau, Caroline; Marchetti, Irène; Tadi, Satish K; Vahldick, Julia; Truong, Lynn N; Zhou, Yuanyue; Sauer, Igor M; Schöning, Wenzel; Na, Il-Kang; Reik, Andreas; Frentsch, Marco; Rosa, Maurus de la; Fenard, David
肿瘤
表观遗传
T细胞
肿瘤免疫
T细胞
细胞生物学
免疫/内分泌
