日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

Gs蛋白偶联受体下游Ca2+信号多样化的分子机制

Julian Brands # ,Sergi Bravo # ,Lars Jürgenliemke # ,Lukas Grätz ,Hannes Schihada ,Fabian Frechen ,Judith Alenfelder ,Cy Pfeil ,Paul Georg Ohse ,Suzune Hiratsuka ,Kouki Kawakami ,Luna C Schmacke ,Nina Heycke ,Asuka Inoue ,Gabriele König ,Alexander Pfeifer ,Dagmar Wachten ,Gunnar Schulte ,Torsten Steinmetzer ,Val J Watts ,Jesús Gomeza ,Katharina Simon ,Evi Kostenis

Pyrazolo-Pyrimidinones with Improved Solubility and Selective Inhibition of Adenylyl Cyclase Type 1 Activity for Treatment of Inflammatory Pain

具有更高溶解度和选择性抑制腺苷酸环化酶1型活性的吡唑并嘧啶酮类化合物用于治疗炎症性疼痛

Annadka Shrinidhi ,Tiffany S Dwyer ,Jason A Scott ,Val J Watts ,Daniel P Flaherty

G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells

蛋白偶联受体 17 通过肠内分泌细胞中的 Gi/o 依赖性机制抑制胰高血糖素样肽-1 的分泌

Jason M Conley, Alexander Jochim, Carmella Evans-Molina, Val J Watts, Hongxia Ren

G protein-coupled receptor 17 inhibits glucagon-like peptide-1 secretion via a Gi/o-dependent mechanism in enteroendocrine cells

蛋白偶联受体 17 通过肠内分泌细胞中的 Gi/o 依赖性机制抑制胰高血糖素样肽-1 的分泌

Jason M Conley, Alexander Jochim, Carmella Evans-Molina, Val J Watts, Hongxia Ren

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

基于蛋白质-蛋白质相互作用的腺苷酸环化酶 1 抑制剂高通量筛选:新型化学型的设计、实施和发现

Tiffany S Dwyer, Joseph B O'Brien, Christopher P Ptak, Justin E LaVigne, Daniel P Flaherty, Val J Watts, David L Roman

Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice

腺苷酸环化酶 1 活性降低可减轻小鼠吗啡引起的痛觉过敏和炎症疼痛

Kayla Johnson, Alexis Doucette, Alexis Edwards, Aleeya Verdi, Ryan McFarland, Shelby Hulke, Amanda Fowler, Val J Watts, Amanda H Klein

Halogen-Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases

基于卤素舞的膦甲氧基乙基 (PME) 取代的 2-氨基噻唑的合成作为细菌腺苷酸环化酶的强效抑制剂

Michal Česnek, Michal Šafránek, Martin Dračínský, Eva Tloušťová, Helena Mertlíková-Kaiserová, Michael P Hayes, Val J Watts, Zlatko Janeba

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels

AKAP79 调控 Orai1 Ca2+ 通道附近的环磷酸腺苷信号体

Pulak Kar, Pradeep Barak, Anna Zerio, Yu-Ping Lin, Amy J Parekh, Val J Watts, Dermot M F Cooper, Manuela Zaccolo, Holger Kramer, Anant B Parekh

Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3-Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase

全基因组小干扰 RNA 筛选揭示了 Cullin3 的作用——一种非常有趣的新基因连接酶信号在腺苷酸环化酶异源致敏中的作用

Zhong Ding, Karin F K Ejendal, Monica Soto-Velasquez, Michael P Hayes, Nicholas Santoro, Martha J Larsen, Val J Watts

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain

优化 1,3,4-恶二唑系列以抑制 Ca2+/钙调蛋白刺激的腺苷酸环化酶 1 和 8 的活性,用于治疗慢性疼痛

Jatinder Kaur, Monica Soto-Velasquez, Zhong Ding, Ahmadreza Ghanbarpour, Markus A Lill, Richard M van Rijn, Val J Watts, Daniel P Flaherty