日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cross-coronavirus host susceptibility loci influence disease severity through immune mediators

冠状病毒宿主易感基因位点通过免疫介质影响疾病严重程度

Risemberg, Ellen L; Leist, Sarah R; Schäfer, Alexandra; Kamat, Kalika D; Bell, Timothy A; Hock, Pablo; Jensen, Kara L; Linnertz, Colton L; Miller, Darla R; Shaw, Ginger D; Pardo Manuel de Villena, Fernando; Baric, Ralph S; Ferris, Martin T; Valdar, William

The impact of early-life exposures on growth and adult gut microbiome composition is dependent on genetic strain and parent- of- origin

早期生活经历对生长发育和成年肠道微生物群组成的影响取决于遗传品系和亲本来源。

Huda, M Nazmul; Kelly, Emer; Barron, Keri; Xue, Jing; Valdar, William; Tarantino, Lisa M; Schoenrock, Sarah; Ideraabdullah, Folami Y; Bennett, Brian J

Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes

基于分子计数表型的基因-治疗相互作用的概率分类

Harigaya, Yuriko; Matoba, Nana; Le, Brandon D; Valone, Jordan M; Stein, Jason L; Love, Michael I; Valdar, William

Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine

利用合作杂交小鼠品系进行基因定位,可以鉴定出影响对可卡因初始敏感性的基因位点。

Schoenrock, Sarah A; Gaines, Christiann H; Kumar, Padam; Khan, Saad; Farrington, Joseph; Ferris, Martin T; de Villena, Fernando Pardo-Manuel; Valdar, William; Bubier, Jason A; Tarantino, Lisa M

A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice

CC027小鼠口服花生后,Themis基因突变导致过敏反应加重。

Risemberg, Ellen L; Smeekens, Johanna M; Cruz Cisneros, Marta C; Hampton, Brea K; Hock, Pablo; Linnertz, Colton L; Miller, Darla R; Orgel, Kelly; Shaw, Ginger D; de Villena, Fernando Pardo Manuel; Burks, A Wesley; Valdar, William; Kulis, Michael D; Ferris, Martin T

Early life exposure to vitamin D deficiency impairs molecular mechanisms that regulate liver cholesterol biosynthesis, energy metabolism, inflammation, and detoxification

早期生命中接触维生素 D 缺乏会损害调节肝脏胆固醇生物合成、能量代谢、炎症和解毒的分子机制

Megan M Knuth, Jing Xue, Marwa Elnagheeb, Raad Z Gharaibeh, Sarah A Schoenrock, Susan McRitchie, Cory Brouwer, Susan J Sumner, Lisa Tarantino, William Valdar, R Scott Rector, Jeremy M Simon, Folami Ideraabdullah

Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets

对菌株、性别和饮食依赖性肠道菌群调节的分析揭示了驱动微生物多样性以响应美国饮食和生酮饮食的关键候选微生物

Salvador, Anna C; Huda, M Nazmul; Arends, Danny; Elsaadi, Ahmed M; Gacasan, C Anthony; Brockmann, Gudrun A; Valdar, William; Bennett, Brian J; Threadgill, David W

Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats

多种性状的基因图谱鉴定出杂交大鼠中肥胖、脂质和胰岛素分泌能力的新基因

Thu Hong-Le, Wesley L Crouse, Gregory R Keele, Katie Holl, Osborne Seshie, Michael Tschannen, Ann Craddock, Swapan K Das, Alexandria M Szalanczy, Bailey McDonald, Michael Grzybowski, Jason Klotz, Neeraj K Sharma, Aron M Geurts, Chia-Chi Chuang Key, Gregory Hawkins, William Valdar, Richard Mott, Leah

Navigating the bridge between wet and dry lab toxicology research to address current challenges with high-dimensional data

利用高维数据,探索湿实验室和干实验室毒理学研究之间的桥梁,以应对当前挑战。

Payton, Alexis; Roell, Kyle R; Rebuli, Meghan E; Valdar, William; Jaspers, Ilona; Rager, Julia E

A Bayesian model selection approach to mediation analysis

贝叶斯模型选择方法在中介分析中的应用

Crouse, Wesley L; Keele, Gregory R; Gastonguay, Madeleine S; Churchill, Gary A; Valdar, William