日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TEIPP-vaccination in checkpoint-resistant non-small cell lung cancer: a first-in-human phase I/II dose-escalation study

TEIPP疫苗治疗免疫检查点耐药性非小细胞肺癌:一项首次人体I/II期剂量递增研究

Emmers, Mitchell; Welters, Marij J P; Dietz, Michelle V; Santegoets, Saskia J; Boekesteijn, Sanne; Stolk, Anouk; Loof, Nikki M; Dumoulin, Daphne W; Geel, Annemarie L; Steinbusch, Lauri C; Valentijn, A Rob P M; Cohen, Danielle; de Miranda, Noel F C C; Smit, Egbert F; Gelderblom, Hans; van Hall, Thorbald; Aerts, Joachim G; van der Burg, Sjoerd H

Ex vivo fluorescence-guided resection margin assessment in breast cancer surgery using a topically applied, cathepsin-activatable imaging agent.

利用局部应用的组织蛋白酶激活成像剂进行乳腺癌手术中离体荧光引导切缘评估

Linders Daan G J, Bijlstra Okker D, Walker Ethan, March Taryn L, Pool Martin, Valentijn A Rob P M, Dijkhuis Tom H, Woltering Jikke N, Pijl Floor R, Noordam Gilbert, van den Burg Davey, van der Sijp Joost R M, Guicherit Onno R, Marinelli Andreas W K S, Burggraaf Jacobus, Rissmann Robert, Bogyo Matthew, Hilling Denise E, Kuppen Peter J K, Straight Brian, Straver Marieke E, Hazelbag Hans Marten, Basilion James P, Vahrmeijer Alexander L

Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery

乳腺癌中的半胱氨酸组织蛋白酶:荧光引导手术的潜在靶点

Linders, Daan G J; Bijlstra, Okker D; Fallert, Laura C; Hilling, Denise E; Walker, Ethan; Straight, Brian; March, Taryn L; Valentijn, A Rob P M; Pool, Martin; Burggraaf, Jacobus; Basilion, James P; Vahrmeijer, Alexander L; Kuppen, Peter J K

Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions

将与优化的 Toll 样受体 2 配体偶联的 HPV-16 E6 合成肽进行皮内接种,在 HPV-16 阳性(癌前)病变患者中显示出安全性和强大的 T 细胞免疫原性。

Speetjens, Frank M; Welters, Marij J P; Slingerland, Marije; van Poelgeest, Mariette I E; de Vos van Steenwijk, Peggy J; Roozen, Inge; Boekestijn, Sanne; Loof, Nikki M; Zom, Gijs G; Valentijn, A Rob P M; Krebber, Willem-Jan; Meeuwenoord, Nico J; Janssen, Catharina A H; Melief, Cornelis J M; van der Marel, Gijs A; Filippov, Dmitri V; van der Burg, Sjoerd H; Gelderblom, Hans; Ossendorp, Ferry

Simplified Monopalmitoyl Toll-like Receptor 2 Ligand Mini-UPam for Self-Adjuvanting Neoantigen-Based Synthetic Cancer Vaccines

用于自佐剂新抗原合成癌症疫苗的简化型单棕榈酰Toll样受体2配体Mini-UPam

van den Ende, Thomas C; Heuts, Jeroen M M; Gential, Geoffroy P P; Visser, Marten; van de Graaff, Michel J; Ho, Nataschja I; Jiskoot, Wim; Valentijn, A Rob P M; Meeuwenoord, Nico J; Overkleeft, Herman S; Codée, Jeroen D C; van der Burg, Sjoerd H; Verdegaal, Els M E; van der Marel, Gijsbert A; Ossendorp, Ferry; Filippov, Dmitri V

Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media

含有新型抗菌合成肽的耳用滴剂:治疗成人慢性化脓性中耳炎的安全性和有效性

Peek, Nanno F A W; Nell, Marja J; Brand, Ronald; Jansen-Werkhoven, Thekla; van Hoogdalem, Ewoud J; Verrijk, Ruud; Vonk, Marcel J; Wafelman, Amon R; Valentijn, A Rob P M; Frijns, Johan H M; Hiemstra, Pieter S; Drijfhout, Jan W; Nibbering, Peter H; Grote, Jan J

Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe

利用低剂量整合素靶向探针进行近红外荧光成像,观察结直肠癌和输尿管情况。

Verbeek, Floris P R; van der Vorst, Joost R; Tummers, Quirijn R J G; Boonstra, Martin C; de Rooij, Karien E; Löwik, Clemens W G M; Valentijn, A Rob P M; van de Velde, Cornelis J H; Choi, Hak Soo; Frangioni, John V; Vahrmeijer, Alexander L

Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice

小鼠体内合成长肽甘露糖基化后,交叉呈递增强,CD8+ T细胞反应改善。

Rauen, Judith; Kreer, Christoph; Paillard, Arlette; van Duikeren, Suzanne; Benckhuijsen, Willemien E; Camps, Marcel G; Valentijn, A Rob P M; Ossendorp, Ferry; Drijfhout, Jan W; Arens, Ramon; Burgdorf, Sven

HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

HPV16合成长肽(HPV16-SLP)疫苗治疗晚期或复发性HPV16诱发妇科癌患者的II期试验

van Poelgeest, Mariette I E; Welters, Marij J P; van Esch, Edith M G; Stynenbosch, Linda F M; Kerpershoek, Gijs; van Persijn van Meerten, Els L; van den Hende, Muriel; Löwik, Margriet J G; Berends-van der Meer, Dorien M A; Fathers, Lorraine M; Valentijn, A Rob P M; Oostendorp, Jaap; Fleuren, Gert Jan; Melief, Cornelis J M; Kenter, Gemma G; van der Burg, Sjoerd H

Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

HPV16阳性外阴病变疫苗接种的成功或失败与诱导的T细胞反应的动力学和表型相关。

Welters, Marij J P; Kenter, Gemma G; de Vos van Steenwijk, Peggy J; Löwik, Margriet J G; Berends-van der Meer, Dorien M A; Essahsah, Farah; Stynenbosch, Linda F M; Vloon, Annelies P G; Ramwadhdoebe, Tamara H; Piersma, Sytse J; van der Hulst, Jeanette M; Valentijn, A Rob P M; Fathers, Lorraine M; Drijfhout, Jan W; Franken, Kees L M C; Oostendorp, Jaap; Fleuren, Gert Jan; Melief, Cornelis J M; van der Burg, Sjoerd H