Valkov相关文献与解析，生知库 | 链接生命科学的每一步

Chiou-Tsun Tsai,Jorge Ibanez-Vega,Pan Yin,Robert Teis,Norihiro Watanabe,Tadahiro Honda,Mikhail Valkov,Peter J Chockley,Lourdes Asenath Jimenez Madrigal,Giedre Krenciute,Maksim Mamonkin

肿瘤

免疫/内分泌

发表日期：2026

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RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

RNA偶联CRISPR筛选揭示ZNF207是早衰症中LMNA异常剪接的调节因子

期刊:Molecular Cell

影响因子:14.5

doi:10.1016/j.molcel.2025.12.003

Amit K Behera,Jeongjin J Kim,Shreya Kordale,Filip Pekovic,Arun Prasath Damodaran,Bandana Kumari,Sandra Vidak,Ethan Dickson,Mei-Sheng Xiao,Gerard Duncan,Thorkell Andresson,Tom Misteli,Eugene Valkov,Thomas Gonatopoulos-Pournatzis

发表日期：2026

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Human pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex to repress mRNAs

人类pumilio蛋白利用模糊多价疏水相互作用募集CCR4-NOT脱腺苷酸酶复合物来抑制mRNA。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2026.111281

Dunshee, Elise B; Saladin, Brenna A; Turner, David J; Qiu, Chen; Dutcher, Robert C; Williams, Jason G; Corbo, Joshua; Wolcott, Olivia R; Korte, Amanda J; Haugen, Rebecca J; Tanaka Hall, Traci M; Valkov, Eugene; Goldstrohm, Aaron C

Human

发表日期：2026

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SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

SP140-RESIST通路调控干扰素mRNA稳定性及抗病毒免疫

期刊:Nature

影响因子:50.5

doi:10.1038/s41586-025-09152-2

Kristen C Witt,Adam Dziulko,Joohyun An,Filip Pekovic,Arthur Xiuyuan Cheng,Grace Y Liu,Ophelia Vosshall Lee,David J Turner,Azra Lari,Moritz M Gaidt,Roberto Chavez,Stefan A Fattinger,Preethy Abraham,Harmandeep Dhaliwal,Angus Y Lee,Dmitri I Kotov,Laurent Coscoy,Britt A Glaunsinger,Eugene Valkov,Edward B Chuong,Russell E Vance

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function

真核生物RNA结合蛋白基序资源揭示了进化动态和基因调控功能

期刊:Nature Biotechnology

影响因子:41.7

doi:10.1038/s41587-025-02733-6

Sasse, Alexander; Ray, Debashish; Laverty, Kaitlin U; Tam, Cyrus L; Albu, Mihai; Zheng, Hong; Levdansky, Yevgen; Lyudovyk, Olga; Dalal, Taykhoom; Nie, Kate; Magis, Cedrik; Notredame, Cedric; Valkov, Eugene; Weirauch, Matthew T; Hughes, Timothy R; Morris, Quaid

信号转导

发表日期：2025

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Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay

细胞内病原体效应蛋白通过抑制mRNA衰变来重编程宿主基因表达。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-61194-2

Levdansky, Yevgen; Deme, Justin C; Turner, David J; Piczak, Claire T; Pekovic, Filip; Valkov, Anna L; Tarasov, Sergey G; Lea, Susan M; Valkov, Eugene

Multivalent interactions with CCR4-NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin.

三四脯氨酸通过与 CCR4-NOT 和 PABPC1 的多价相互作用来决定 mRNA 抑制效率

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-62741-7

Pekovic Filip, Lai Wi S, Corbo Joshua, Hicks Stephanie N, Luke Keiko, Blackshear Perry J, Valkov Eugene

信号转导

发表日期：2025

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Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome

血浆细胞外囊泡携带的microRNA与急性冠脉综合征后的心力衰竭和心血管死亡相关

期刊:

影响因子:15.5

doi:10.1016/j.vesic.2025.100070

Worawan B Limpitikul ，Michael G Silverman ，Nedyalka Valkov ，Jeong-Gun Park ，Ashish Yeri ，Fernando Camacho Garcia ，Guoping Li ，Priyanka Gokulnath ，Marta Garcia-Contreras ，Eric Alsop ，Elizabeth Hutchins ，Michail Spanos ，Claire Lin ，Kriti Bomb ，Anthony Rosenzweig ，Raymond Kwong ，Kendall van-Keuren Jensen ，James L Januzzi Jr ，Ravi Shah ，David A Morrow ，Marc S Sabatine ，Saumya Das

HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

在人源化小鼠移植模型中，HLA配型或HLA I/II类基因的CRISPR编辑可使同种异体人源调节性T细胞疗法实现植入并发挥有效功能。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-64945-3.

Oliver McCallion #,Weijie Du #,Viktor Glaser #,Kate Milward,Sarah Short,Merve Bilici,Amy Cross,Helen Stark,Clemens Franke,Jonas Kath,Mikhail Valkov,Mingxing Yang,Leila Amini,Annette Künkele,Julia K Polansky,Michael Schmueck-Henneresse,Hans-Dieter Volk,Petra Reinke,Dimitrios L Wagner,Joanna Hester,Fadi Issa

Conserved and divergent features of human mRNA decapping revealed by biochemical reconstitution

生化重组揭示人类mRNA脱帽的保守和差异特征

Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor

通过免疫突触稳定受体增强CAR和TCR介导的癌症靶向治疗

RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

RNA偶联CRISPR筛选揭示ZNF207是早衰症中LMNA异常剪接的调节因子

Human pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex to repress mRNAs

人类pumilio蛋白利用模糊多价疏水相互作用募集CCR4-NOT脱腺苷酸酶复合物来抑制mRNA。

SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

SP140-RESIST通路调控干扰素mRNA稳定性及抗病毒免疫

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function

真核生物RNA结合蛋白基序资源揭示了进化动态和基因调控功能

Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay

细胞内病原体效应蛋白通过抑制mRNA衰变来重编程宿主基因表达。

Multivalent interactions with CCR4-NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin.

三四脯氨酸通过与 CCR4-NOT 和 PABPC1 的多价相互作用来决定 mRNA 抑制效率

Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome

血浆细胞外囊泡携带的microRNA与急性冠脉综合征后的心力衰竭和心血管死亡相关

HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

在人源化小鼠移植模型中，HLA配型或HLA I/II类基因的CRISPR编辑可使同种异体人源调节性T细胞疗法实现植入并发挥有效功能。