日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ATR promotes mTORC1 activity via de novo cholesterol synthesis

ATR通过从头合成胆固醇促进mTORC1活性。

Naveen Kumar Tangudu ,Alexandra N Grumet ,Richard Fang ,Raquel Buj ,Aidan R Cole ,Apoorva Uboveja ,Amandine Amalric ,Baixue Yang ,Zhentai Huang ,Cassandra Happe ,Mai Sun ,Stacy L Gelhaus ,Matthew L MacDonald ,Nadine Hempel ,Nathaniel W Snyder ,Katarzyna M Kedziora ,Alexander J Valvezan ,Katherine M Aird

Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatment

肠道菌群磷脂调节肠道基因表达,并能抵消抗生素治疗的影响。

Blaser, Martin; Zhang, Xue-Song; Zhang, Meifan; Wang, Yujue; Sun, Haipeng; Scarnati, Matthew; Gao, Zhan; Yin, Yue; Zerbe, Christa; Falcone, Emilia; Lally, Mary; Joshi, Jay; Bhattacharya, Sneha; Diaz-Rubio, Maria; Bharj, Disha; Patel, Disha; Pan, Samuel; Ro, Gabrielle; Grenard, Jessica; Armstrong, Abigail; Valvezan, Alexander; Holland, Steven; Mulle, Jenifer; Dominguez-Bello, Maria; Su, Xiaoyang

mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction

mTORC1活性在整个细胞周期中呈周期性波动,促进细胞进入有丝分裂,并对自噬诱导产生不同的影响。

Joshi, Jay N; Lerner, Ariel D; Scallo, Frank; Grumet, Alexandra N; Matteson, Paul; Millonig, James H; Valvezan, Alexander J

mTORC1 activity oscillates throughout the cell cycle promoting mitotic entry and differentially influencing autophagy induction

mTORC1 活性在整个细胞周期中振荡,促进有丝分裂进入并对自噬诱导产生不同的影响

Jay N Joshi, Ariel D Lerner, Frank Scallo, Alexandra N Grumet, Paul Matteson, James H Millonig, Alexander J Valvezan

The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish

肿瘤抑制基因腺瘤性息肉病基因(apc)是斑马鱼神经嵴依赖性颅面发育所必需的

Liu, Xiaolei; Jones, William D; Quesnel-Vallières, Mathieu; Devadiga, Sudhish A; Lorent, Kristin; Valvezan, Alexander J; Myers, Rebecca L; Li, Ning; Lengner, Christopher J; Barash, Yoseph; Pack, Michael; Klein, Peter S

Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

谷氨酰胺合成酶通过维持氮稳态和抑制 mTORC1 来限制 β-catenin 突变的肝癌生长

Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J Bott, Sara Maimouni, Heineken Q Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao, Wei-Xing Zong

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

mTOR抑制剂对促生存蛋白的相互影响决定了结节性硬化症的治疗反应。

Molly C McNamara ,Aaron M Hosios ,Margaret E Torrence ,Ting Zhao ,Cameron Fraser ,Meghan Wilkinson ,David J Kwiatkowski ,Elizabeth P Henske ,Chin-Lee Wu ,Kristopher A Sarosiek ,Alexander J Valvezan ,Brendan D Manning

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

mTORC1 介导的 ATF4 激活促进生长信号下游的蛋白质和谷胱甘肽合成

Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning

IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex

IMPDH 抑制剂用于结节性硬化症的抗肿瘤治疗

Alexander J Valvezan, Molly C McNamara, Spencer K Miller, Margaret E Torrence, John M Asara, Elizabeth P Henske, Brendan D Manning

Molecular logic of mTORC1 signalling as a metabolic rheostat

mTORC1信号通路作为代谢调节器的分子逻辑

Valvezan, Alexander J; Manning, Brendan D