CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors.
CHD1 缺失会重编程 SREBP2 驱动的胆固醇合成，从而促进 SPOP 突变前列腺肿瘤的雄激素反应性生长和去势抵抗
期刊:Nature Cancer
影响因子:28.5
doi:10.1038/s43018-025-00952-z
Chen Feiyu, Li Haoyan, Wang Yin, Tang Ximing, Lin Kevin, Li Qidong, Meng Chenling, Shi Wei, Leo Javier, Liang Xin, Zhang Jie, Van Vivien, Mahmud Iqbal, Wei Bo, Lorenzi Philip L, Raso Maria G, Aparicio Ana, Lu Yue, Frigo Daniel E, Gan Boyi, Zhao Di
