RNA-based co-transfer of human CD8αβ with WT1-specific TCRαβ redirects tumor recognition by CD4 and γδ T-cells towards MHC class I-restricted WT1 epitopes and boosts CD8 T-cell responses with or without CD3 mRNA
基于RNA的人CD8αβ与WT1特异性TCRαβ共转移,可将CD4和γδ T细胞对肿瘤的识别重定向至MHC I类限制性WT1表位,并增强CD8 T细胞应答,无论是否存在CD3 mRNA。
期刊:Experimental Hematology & Oncology
影响因子:13.5
doi:10.1186/s40164-026-00764-6
Campillo-Davo, Diana; Flumens, Donovan; Berneman, Zwi N; Fujiki, Fumihiro; Roex, Gils; Versteven, Maarten; Van Acker, Heleen H; Van Tendeloo, Viggo F I; Sugiyama, Haruo; Anguille, Sébastien; Lion, Eva
肿瘤
T细胞
肿瘤免疫
CD8
CD3
T细胞
WT1
细胞生物学
CD4
免疫/内分泌