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Cevirgel, Alper; van der Heiden, Marieke; Shetty, Sudarshan A; Viljanen, Markus; Vos, Martijn; Bijvank, Elske; van Sleen, Yannick; Imhof, Celine; Rolwes, Joeri A J; Samson, Leonard Daniël; Beckers, Lisa; Rots, Nynke; van Beek, Josine; Buisman, Anne-Marie; van Baarle, Debbie

免疫/内分泌

发表日期：2025

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The TNFα-binding domain of the therapeutic antibody adalimumab elicits CD4 T-cell responses in rheumatoid arthritis patients

治疗性抗体阿达木单抗的TNFα结合域可诱导类风湿性关节炎患者产生CD4 T细胞反应。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2025.1549781

Makuch, Mateusz; van Beek, Josine; Wijbrandts, Carla A; Aalbers, Marja; Stas, Philippe; Meijer, Alexander B; Brinke, Anja Ten; Rispens, Theo; Tak, Paul Peter; Wolbink, Gertjan; Schuurman, Janine; Parren, Paul W H I; van Ham, S Marieke

Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation

重新评估CD57作为T细胞衰老标志物的价值：对免疫衰老和分化的意义

期刊:Immunity & Ageing

影响因子:5.6

doi:10.1186/s12979-025-00542-8

Autaa, Gaëlle; Korenkov, Daniil; van Beek, Josine; Pellegrin, Isabelle; Parfait, Béatrice; van Baarle, Debbie; Launay, Odile; Tartour, Eric; Appay, Victor

Influence of perceived influenza-like symptoms on intention to receive seasonal influenza vaccination

感知到的流感样症状对接种季节性流感疫苗意愿的影响

期刊:BMC Public Health

影响因子:3.6

doi:10.1186/s12889-025-22144-1

Eilers, Renske; Groenendijk, Fleur H; Lehman, Birthe A; Rots, Nynke Y; de Melker, Hester E; Mollema, Liesbeth; van Beek, Josine

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

对同一成年人进行多种疫苗的比较研究揭示了疫苗特异性和年龄相关的体液免疫反应模式：一项开放性 IV 期试验

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-024-50760-9

van der Heiden, Marieke; Shetty, Sudarshan; Bijvank, Elske; Beckers, Lisa; Cevirgel, Alper; van Sleen, Yannick; Tcherniaeva, Irina; Ollinger, Thierry; Burny, Wivine; van Binnendijk, Rob S; van Houten, Marianne A; Buisman, Anne-Marie; Rots, Nynke Y; van Beek, Josine; van Baarle, Debbie

免疫/内分泌

发表日期：2024

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Pre-vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination

接种疫苗前的免疫类型揭示了对流感疫苗的弱抗体反应者和强抗体反应者

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.14048

Cevirgel, Alper; Shetty, Sudarshan A; Vos, Martijn; Nanlohy, Nening M; Beckers, Lisa; Bijvank, Elske; Rots, Nynke; van Beek, Josine; Buisman, Anne-Marie; van Baarle, Debbie

Distinct T cell responsiveness to different COVID-19 vaccines and cross-reactivity to SARS-CoV-2 variants with age and CMV status.

T 细胞对不同 COVID-19 疫苗的反应性存在差异，并且与年龄和 CMV 感染状况有关，对 SARS-CoV-2 变种存在交叉反应性

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2024.1392477

Brummelman Jolanda, SuÃ¡rez-HernÃ¡ndez Sara, de Rond Lia, Bogaard-van Maurik Marjan, Molenaar Petra, van Wijlen Emma, Oomen Debbie, Beckers Lisa, Rots Nynke Y, van Beek Josine, Nicolaie Mioara A, van Els CÃ©cile A C M, Boer Mardi C, Kaaijk Patricia, Buisman Anne-Marie, de Wit Jelle

细胞生物学

发表日期：2024

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Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection.

早期免疫分析显示，在初次感染 SARS-CoV-2 几天后，儿童和成人之间存在不同的炎症反应

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2024.1359993

Van de Garde Martijn D B, Miranda-Bedate Alberto, Nanlohy Nening M, Jacobi Ronald H J, Meijer Adam, Reukers Daphne F M, Van Beek Josine, Van Els Cecile A C M, Van Baarle Debbie, Rots Nynke Y, De Wit Jelle, Pinelli Elena

Delineating immune variation between adult and children COVID-19 cases and associations with disease severity

阐明成人和儿童新冠肺炎病例之间的免疫差异及其与疾病严重程度的关联

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-024-55148-9

Cevirgel, Alper; Vos, Martijn; Holtrop, Anne Floor; Beckers, Lisa; Reukers, Daphne F M; Meijer, Adam; Rots, Nynke; van Beek, Josine; van Baarle, Debbie; de Wit, Jelle

Prevalence of human respiratory pathogens and associated mucosal cytokine levels in young children and adults: a cross-sectional observational study in the Netherlands during the winter of 2012/2013

2012/2013年冬季荷兰儿童和成人呼吸道病原体流行情况及相关黏膜细胞因子水平：一项横断面观察研究

期刊:Pathogens and Disease

影响因子:2.7

doi:10.1093/femspd/ftae010

van Kasteren, Puck B; Gelderloos, Anne T; Nicolaie, Mioara Alina; den Hartog, Gerco; Vissers, Marloes; Luytjes, Willem; Rots, Nynke Y; van Beek, Josine

Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

接种疫苗前的免疫型和免疫熵是多重疫苗反应性的指标

The TNFα-binding domain of the therapeutic antibody adalimumab elicits CD4 T-cell responses in rheumatoid arthritis patients

治疗性抗体阿达木单抗的TNFα结合域可诱导类风湿性关节炎患者产生CD4 T细胞反应。

Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation

重新评估CD57作为T细胞衰老标志物的价值：对免疫衰老和分化的意义

Influence of perceived influenza-like symptoms on intention to receive seasonal influenza vaccination

感知到的流感样症状对接种季节性流感疫苗意愿的影响

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

对同一成年人进行多种疫苗的比较研究揭示了疫苗特异性和年龄相关的体液免疫反应模式：一项开放性 IV 期试验

Pre-vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination

接种疫苗前的免疫类型揭示了对流感疫苗的弱抗体反应者和强抗体反应者

Distinct T cell responsiveness to different COVID-19 vaccines and cross-reactivity to SARS-CoV-2 variants with age and CMV status.

T 细胞对不同 COVID-19 疫苗的反应性存在差异，并且与年龄和 CMV 感染状况有关，对 SARS-CoV-2 变种存在交叉反应性

Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection.

早期免疫分析显示，在初次感染 SARS-CoV-2 几天后，儿童和成人之间存在不同的炎症反应

Delineating immune variation between adult and children COVID-19 cases and associations with disease severity

阐明成人和儿童新冠肺炎病例之间的免疫差异及其与疾病严重程度的关联

Prevalence of human respiratory pathogens and associated mucosal cytokine levels in young children and adults: a cross-sectional observational study in the Netherlands during the winter of 2012/2013

2012/2013年冬季荷兰儿童和成人呼吸道病原体流行情况及相关黏膜细胞因子水平：一项横断面观察研究