日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC)

MEK1/2 抑制剂比美替尼联合 MET 抑制剂克唑替尼治疗 RAS 突变型晚期结直肠癌患者的 Ia/b 期研究 (MErCuRIC)

Aroldi, Francesca; Elez, Elena; André, Thierry; Perkins, Geraldine; Prenen, Hans; Popovici, Vlad; Gallagher, Peter; Houlden, Jennifer; Collins, Linda; Roberts, Corran; Rolfo, Christian; Di Nicolantonio, Federica; Grayson, Margaret; Boyd, Ruth; Bettens, Karolien; Delfavero, Jurgen; Coyle, Victoria; Lawler, Mark; Khawaja, Hajrah; Laurent-Puig, Pierre; Salto-Tellez, Manuel; Maughan, Tim S; Tabernero, Josep; Adams, Richard; Jones, Robert; Hennessy, Bryan T; Bardelli, Alberto; Peeters, Marc; Middleton, Mark R; Wilson, Richard H; Van Schaeybroeck, Sandra

A phase Ia study of the MEK1/2 inhibitor PD-0325901 with the c-MET inhibitor crizotinib in patients with advanced solid cancers

一项针对晚期实体瘤患者的MEK1/2抑制剂PD-0325901联合c-MET抑制剂克唑替尼的Ia期研究

Gallagher, Peter; Rolfo, Christian; Elez, Elena; Taieb, Julien; Houlden, Jennifer; Collins, Linda; Roberts, Corran; André, Thierry; Lawler, Mark; Di Nicolantonio, Federica; Grayson, Margaret; Boyd, Ruth; Popovici, Vlad; Bardelli, Alberto; Carson, Robbie; Khawaja, Hajrah; Laurent-Puig, Pierre; Salto-Tellez, Manuel; Hennessy, Bryan T; Maughan, Tim S; Tabernero, Josep; Adams, Richard; Jones, Robert; Peeters, Marc; Middleton, Mark R; Wilson, Richard H; Van Schaeybroeck, Sandra

An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution

结直肠癌组织中细胞凋亡能力的肿瘤间和肿瘤内异质性的单细胞分辨率图谱

Lindner, Andreas Ulrich; Salvucci, Manuela; McDonough, Elizabeth; Cho, Sanghee; Stachtea, Xanthi; O'Connell, Emer P; Corwin, Alex D; Santamaria-Pang, Alberto; Carberry, Steven; Fichtner, Michael; Van Schaeybroeck, Sandra; Laurent-Puig, Pierre; Burke, John P; McNamara, Deborah A; Lawler, Mark; Sood, Anup; Graf, John F; Rehm, Markus; Dunne, Philip D; Longley, Daniel B; Ginty, Fiona; Prehn, Jochen H M

Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications

在具有人群代表性的 II-III 期结肠癌队列中进行正交 MET 分析:预后和潜在治疗意义

Craig, Stephanie G; Mende, Svenja; Humphries, Matthew P; Bingham, Victoria; Viratham Pulsawatdi, Amélie; Loughrey, Maurice B; Coleman, Helen G; McQuaid, Stephen; Wilson, Richard H; Van Schaeybroeck, Sandra; James, Jacqueline A; Salto-Tellez, Manuel

Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells.

利用 ONC201 调节未折叠蛋白反应,从而影响前列腺癌细胞的放射反应

Amoroso Francesca, Glass Kimberley, Singh Reema, Liberal Francisco, Steele Rebecca E, Maguire Sarah, Tarapore Rohinton, Allen Joshua E, Van Schaeybroeck Sandra, Butterworth Karl T, Prise Kevin, O'Sullivan Joe M, Jain Suneil, Waugh David J, Mills Ian G

Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer

将超强效的奥瑞他汀活性基团与西妥昔单抗进行可控偶联,可得到用于靶向EGFR治疗KRAS突变型胰腺癌的新一代抗体药物偶联物。

Greene, Michelle K; Chen, Ting; Robinson, Eifion; Straubinger, Ninfa L; Minx, Charlene; Chan, Darren K W; Wang, Jun; Burrows, James F; Van Schaeybroeck, Sandra; Baker, James R; Caddick, Stephen; Longley, Daniel B; Mager, Donald E; Straubinger, Robert M; Chudasama, Vijay; Scott, Christopher J

The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer

未折叠蛋白反应:BRAF突变型结直肠癌预后不良的新型治疗靶点

Forsythe, Nicholas; Refaat, Alaa; Javadi, Arman; Khawaja, Hajrah; Weir, Jessica-Anne; Emam, Heba; Allen, Wendy L; Burkamp, Frank; Popovici, Vlad; Jithesh, Puthen V; Isella, Claudio; Labonte, Melissa J; Mills, Ian G; Johnston, Patrick G; Van Schaeybroeck, Sandra

Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

建立以研究为导向的多方利益相关者伙伴关系,以提升人群层面的患者护理水平:北爱尔兰综合癌症计划

Lawler, Mark; Gavin, Anna; Salto-Tellez, Manuel; Kennedy, Richard D; Van Schaeybroeck, Sandra; Wilson, Richard H; Harkin, Denis Paul; Grayson, Margaret; Boyd, Ruth E; Hamilton, Peter W; McArt, Darragh G; James, Jacqueline; Robson, Tracy; Ladner, Robert D; Prise, Kevin M; O'Sullivan, Joe M; Harrison, Timothy; Murray, Liam; Johnston, Patrick G; Waugh, David J

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies

利用来自多个结直肠癌数据集的联合基因特征进行连接性映射,识别出候选药物,包括现有化疗药物。

Wen, Qing; O'Reilly, Paul; Dunne, Philip D; Lawler, Mark; Van Schaeybroeck, Sandra; Salto-Tellez, Manuel; Hamilton, Peter; Zhang, Shu-Dong

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer

AXL是固有侵袭和化疗诱导侵袭的关键调节因子,并能预测早期结肠癌的不良临床预后。

Dunne, Philip D; McArt, Darragh G; Blayney, Jaine K; Kalimutho, Murugan; Greer, Samanda; Wang, Tingting; Srivastava, Supriya; Ong, Chee Wee; Arthur, Ken; Loughrey, Maurice; Redmond, Keara; Longley, Daniel B; Salto-Tellez, Manuel; Johnston, Patrick G; Van Schaeybroeck, Sandra