Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC β-Lactamase
NMR 揭示的不同构象导致 KPC β-内酰胺酶 D179Y 变体对头孢他啶/阿维巴坦产生耐药性,并对美罗培南和亚胺培南产生敏感性
期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.1
doi:10.1128/aac.02124-21
Magdalena A Taracila #, Christopher R Bethel #, Andrea M Hujer #, Krisztina M Papp-Wallace, Melissa D Barnes, Joseph D Rutter, Jamie VanPelt, Ben A Shurina, Focco van den Akker, Cornelius J Clancy, M Hong Nguyen, Shaoji Cheng, Ryan K Shields, Richard C Page, Robert A Bonomo